SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fub'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
4 / 8 SER A 148
GLY A 127
HIS A 153
THR A 154
SAH  A 409 ( 4.2A)
None
None
None
0.75A 1c9sI-5fubA:
undetectable
1c9sJ-5fubA:
undetectable
1c9sI-5fubA:
14.50
1c9sJ-5fubA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
4 / 7 GLY A 127
HIS A 153
THR A 154
SER A 148
None
None
None
SAH  A 409 ( 4.2A)
0.82A 1c9sT-5fubA:
undetectable
1c9sU-5fubA:
undetectable
1c9sT-5fubA:
14.50
1c9sU-5fubA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
4 / 8 GLY A 127
HIS A 153
THR A 154
SER A 148
None
None
None
SAH  A 409 ( 4.2A)
0.80A 1c9sU-5fubA:
undetectable
1c9sV-5fubA:
undetectable
1c9sU-5fubA:
14.50
1c9sV-5fubA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
4 / 7 GLY A 127
HIS A 153
THR A 154
SER A 148
None
None
None
SAH  A 409 ( 4.2A)
0.76A 1gtfL-5fubA:
undetectable
1gtfM-5fubA:
undetectable
1gtfL-5fubA:
14.50
1gtfM-5fubA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
4 / 8 GLY A 127
HIS A 153
THR A 154
SER A 148
None
None
None
SAH  A 409 ( 4.2A)
0.78A 1gtfN-5fubA:
undetectable
1gtfO-5fubA:
undetectable
1gtfN-5fubA:
14.50
1gtfO-5fubA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
5 / 12 TYR A  84
GLY A 125
VAL A 128
ALA A 147
SER A 148
SAH  A 409 ( 3.6A)
SAH  A 409 ( 3.7A)
None
SAH  A 409 (-3.5A)
SAH  A 409 ( 4.2A)
0.75A 1kiaA-5fubA:
8.7
1kiaA-5fubA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
5 / 12 TYR A  84
GLY A 125
VAL A 128
ALA A 147
SER A 148
SAH  A 409 ( 3.6A)
SAH  A 409 ( 3.7A)
None
SAH  A 409 (-3.5A)
SAH  A 409 ( 4.2A)
0.75A 1kiaD-5fubA:
8.4
1kiaD-5fubA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
5 / 12 TYR A  84
GLY A 125
VAL A 128
ALA A 147
SER A 148
SAH  A 409 ( 3.6A)
SAH  A 409 ( 3.7A)
None
SAH  A 409 (-3.5A)
SAH  A 409 ( 4.2A)
0.71A 1nbhA-5fubA:
8.4
1nbhA-5fubA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
5 / 12 TYR A  84
GLY A 125
VAL A 128
ALA A 147
SER A 148
SAH  A 409 ( 3.6A)
SAH  A 409 ( 3.7A)
None
SAH  A 409 (-3.5A)
SAH  A 409 ( 4.2A)
0.71A 1nbhB-5fubA:
8.2
1nbhB-5fubA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
5 / 12 TYR A  84
GLY A 125
VAL A 128
ALA A 147
SER A 148
SAH  A 409 ( 3.6A)
SAH  A 409 ( 3.7A)
None
SAH  A 409 (-3.5A)
SAH  A 409 ( 4.2A)
0.72A 1nbhC-5fubA:
8.2
1nbhC-5fubA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
5 / 12 TYR A  84
GLY A 125
VAL A 128
ALA A 147
SER A 148
SAH  A 409 ( 3.6A)
SAH  A 409 ( 3.7A)
None
SAH  A 409 (-3.5A)
SAH  A 409 ( 4.2A)
0.71A 1nbhD-5fubA:
8.5
1nbhD-5fubA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
5 / 12 TYR A  84
GLY A 125
VAL A 128
ALA A 147
SER A 148
SAH  A 409 ( 3.6A)
SAH  A 409 ( 3.7A)
None
SAH  A 409 (-3.5A)
SAH  A 409 ( 4.2A)
0.81A 1nbiA-5fubA:
8.1
1nbiA-5fubA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
5 / 12 TYR A  84
GLY A 125
VAL A 128
ALA A 147
SER A 148
SAH  A 409 ( 3.6A)
SAH  A 409 ( 3.7A)
None
SAH  A 409 (-3.5A)
SAH  A 409 ( 4.2A)
0.82A 1nbiB-5fubA:
8.1
1nbiB-5fubA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
5 / 12 GLY A 125
THR A 126
ALA A 147
SER A 148
MET A 150
SAH  A 409 ( 3.7A)
None
SAH  A 409 (-3.5A)
SAH  A 409 ( 4.2A)
None
1.31A 1nbiC-5fubA:
8.1
1nbiC-5fubA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
5 / 12 TYR A  84
GLY A 125
THR A 126
ALA A 147
SER A 148
SAH  A 409 ( 3.6A)
SAH  A 409 ( 3.7A)
None
SAH  A 409 (-3.5A)
SAH  A 409 ( 4.2A)
0.94A 1nbiC-5fubA:
8.1
1nbiC-5fubA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
5 / 12 GLY A 125
THR A 126
ALA A 147
SER A 148
MET A 150
SAH  A 409 ( 3.7A)
None
SAH  A 409 (-3.5A)
SAH  A 409 ( 4.2A)
None
1.27A 1nbiD-5fubA:
8.1
1nbiD-5fubA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
5 / 12 TYR A  84
GLY A 125
THR A 126
ALA A 147
SER A 148
SAH  A 409 ( 3.6A)
SAH  A 409 ( 3.7A)
None
SAH  A 409 (-3.5A)
SAH  A 409 ( 4.2A)
0.93A 1nbiD-5fubA:
8.1
1nbiD-5fubA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
4 / 8 GLY A 127
HIS A 153
THR A 154
SER A 148
None
None
None
SAH  A 409 ( 4.2A)
0.76A 1utdI-5fubA:
undetectable
1utdJ-5fubA:
undetectable
1utdI-5fubA:
14.50
1utdJ-5fubA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
3 / 3 THR A 100
PRO A  98
THR A 102
None
0.74A 209dC-5fubA:
undetectable
209dC-5fubA:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
4 / 5 LEU A 136
PRO A 139
ALA A 137
ILE A 107
CL  A1409 ( 4.9A)
None
None
None
1.04A 2aofB-5fubA:
undetectable
2aofB-5fubA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
5 / 12 GLY A 123
GLY A 125
ALA A 147
ALA A 174
GLU A 175
SAH  A 409 (-3.0A)
SAH  A 409 ( 3.7A)
SAH  A 409 (-3.5A)
SAH  A 409 (-3.9A)
SAH  A 409 (-3.1A)
0.48A 2gluA-5fubA:
11.5
2gluA-5fubA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
4 / 6 LEU A 177
MET A 218
MET A 289
LEU A 212
None
1.44A 2oz7A-5fubA:
undetectable
2oz7A-5fubA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
5 / 12 VAL A 187
GLN A 105
ILE A 107
ASN A 110
SER A 109
None
1.34A 2vdyA-5fubA:
undetectable
2vdyA-5fubA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
4 / 5 VAL A 106
TYR A 103
VAL A 187
ASP A 121
None
None
None
SAH  A 409 ( 4.5A)
1.35A 2x45A-5fubA:
undetectable
2x45A-5fubA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
3 / 3 GLU A 275
HIS A 270
HIS A 271
None
None
EDO  A1412 (-4.0A)
0.94A 3co4A-5fubA:
undetectable
3co4A-5fubA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
5 / 12 LEU A 120
LEU A 212
ALA A 207
ALA A 174
GLU A 146
None
None
None
SAH  A 409 (-3.9A)
SAH  A 409 (-2.6A)
1.08A 3cwkA-5fubA:
1.7
3cwkA-5fubA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
6 / 11 GLY A 123
GLY A 125
ALA A 147
ALA A 174
GLU A 175
ARG A  99
SAH  A 409 (-3.0A)
SAH  A 409 ( 3.7A)
SAH  A 409 (-3.5A)
SAH  A 409 (-3.9A)
SAH  A 409 (-3.1A)
SAH  A 409 (-2.7A)
0.87A 3g88A-5fubA:
9.3
3g88A-5fubA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
6 / 11 GLY A 123
GLY A 125
ALA A 147
ALA A 174
GLU A 175
ARG A  99
SAH  A 409 (-3.0A)
SAH  A 409 ( 3.7A)
SAH  A 409 (-3.5A)
SAH  A 409 (-3.9A)
SAH  A 409 (-3.1A)
SAH  A 409 (-2.7A)
0.90A 3g88B-5fubA:
9.9
3g88B-5fubA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
6 / 12 GLY A 123
GLY A 125
ALA A 147
ALA A 174
GLU A 175
ARG A  99
SAH  A 409 (-3.0A)
SAH  A 409 ( 3.7A)
SAH  A 409 (-3.5A)
SAH  A 409 (-3.9A)
SAH  A 409 (-3.1A)
SAH  A 409 (-2.7A)
0.86A 3g89A-5fubA:
9.4
3g89A-5fubA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
6 / 11 GLY A 123
GLY A 125
ALA A 147
ALA A 174
GLU A 175
ARG A  99
SAH  A 409 (-3.0A)
SAH  A 409 ( 3.7A)
SAH  A 409 (-3.5A)
SAH  A 409 (-3.9A)
SAH  A 409 (-3.1A)
SAH  A 409 (-2.7A)
0.85A 3g89B-5fubA:
10.3
3g89B-5fubA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
6 / 12 GLY A 123
GLY A 125
ALA A 147
ALA A 174
GLU A 175
ARG A  99
SAH  A 409 (-3.0A)
SAH  A 409 ( 3.7A)
SAH  A 409 (-3.5A)
SAH  A 409 (-3.9A)
SAH  A 409 (-3.1A)
SAH  A 409 (-2.7A)
0.84A 3g8bA-5fubA:
10.2
3g8bA-5fubA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
6 / 12 GLY A 123
GLY A 125
ALA A 147
ALA A 174
GLU A 175
ARG A  99
SAH  A 409 (-3.0A)
SAH  A 409 ( 3.7A)
SAH  A 409 (-3.5A)
SAH  A 409 (-3.9A)
SAH  A 409 (-3.1A)
SAH  A 409 (-2.7A)
0.86A 3g8bB-5fubA:
9.0
3g8bB-5fubA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
4 / 8 LEU A 114
SER A 221
GLY A 332
PRO A 333
None
1.15A 3hcrA-5fubA:
undetectable
3hcrA-5fubA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
5 / 9 VAL A 284
PHE A 317
ILE A 227
PHE A 306
ALA A 368
None
1.24A 3me6D-5fubA:
undetectable
3me6D-5fubA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
4 / 8 PHE A 304
VAL A 284
ILE A 385
GLY A 302
None
0.97A 3n9jA-5fubA:
undetectable
3n9jA-5fubA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
4 / 6 GLY A 125
THR A 126
GLU A 146
ASP A 121
SAH  A 409 ( 3.7A)
None
SAH  A 409 (-2.6A)
SAH  A 409 ( 4.5A)
0.92A 3ps9A-5fubA:
5.6
3ps9A-5fubA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
4 / 6 GLY A 125
GLU A 146
ASP A 121
GLU A 175
SAH  A 409 ( 3.7A)
SAH  A 409 (-2.6A)
SAH  A 409 ( 4.5A)
SAH  A 409 (-3.1A)
0.95A 3vywC-5fubA:
6.1
3vywC-5fubA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
5 / 12 VAL A 187
GLN A 105
ILE A 107
ASN A 110
SER A 109
None
1.38A 4c49B-5fubA:
undetectable
4c49B-5fubA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
5 / 12 VAL A 187
GLN A 105
ILE A 107
ASN A 110
SER A 109
None
1.31A 4c49C-5fubA:
undetectable
4c49C-5fubA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
5 / 12 VAL A 187
GLN A 105
ILE A 107
ASN A 110
SER A 109
None
1.39A 4c49D-5fubA:
undetectable
4c49D-5fubA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
4 / 4 LEU A 201
LEU A 225
GLN A 293
GLU A 298
None
1.00A 4i41A-5fubA:
undetectable
4i41A-5fubA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
4 / 8 THR A 318
SER A 322
THR A 226
VAL A 228
None
EDO  A1414 ( 4.3A)
EDO  A1414 ( 3.9A)
None
0.72A 4ik7B-5fubA:
undetectable
4ik7B-5fubA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
5 / 12 TYR A  84
GLY A 123
GLY A 125
SER A 148
ALA A 174
SAH  A 409 ( 3.6A)
SAH  A 409 (-3.0A)
SAH  A 409 ( 3.7A)
SAH  A 409 ( 4.2A)
SAH  A 409 (-3.9A)
0.77A 4krhA-5fubA:
9.7
4krhA-5fubA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
5 / 12 TYR A  84
GLY A 123
GLY A 125
SER A 148
ALA A 174
SAH  A 409 ( 3.6A)
SAH  A 409 (-3.0A)
SAH  A 409 ( 3.7A)
SAH  A 409 ( 4.2A)
SAH  A 409 (-3.9A)
0.82A 4krhB-5fubA:
9.8
4krhB-5fubA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
4 / 5 LEU A 201
ASP A 209
GLU A 175
VAL A 145
None
None
SAH  A 409 (-3.1A)
None
1.13A 4nkvA-5fubA:
undetectable
4nkvA-5fubA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
4 / 6 LEU A 352
LEU A 355
ILE A 227
PHE A 317
None
1.26A 4y4dA-5fubA:
undetectable
4y4dA-5fubA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
4 / 8 SER A 148
GLY A 127
HIS A 153
THR A 154
SAH  A 409 ( 4.2A)
None
None
None
0.76A 5eevL-5fubA:
undetectable
5eevV-5fubA:
undetectable
5eevL-5fubA:
14.50
5eevV-5fubA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
4 / 8 SER A 148
GLY A 127
HIS A 153
THR A 154
SAH  A 409 ( 4.2A)
None
None
None
0.76A 5eewL-5fubA:
undetectable
5eewV-5fubA:
undetectable
5eewL-5fubA:
14.50
5eewV-5fubA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
4 / 8 SER A 148
GLY A 127
HIS A 153
THR A 154
SAH  A 409 ( 4.2A)
None
None
None
0.76A 5eezL-5fubA:
undetectable
5eezV-5fubA:
undetectable
5eezL-5fubA:
14.50
5eezV-5fubA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
4 / 8 SER A 148
GLY A 127
HIS A 153
THR A 154
SAH  A 409 ( 4.2A)
None
None
None
0.76A 5ef1L-5fubA:
undetectable
5ef1V-5fubA:
undetectable
5ef1L-5fubA:
14.50
5ef1V-5fubA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
4 / 8 SER A 148
GLY A 127
HIS A 153
THR A 154
SAH  A 409 ( 4.2A)
None
None
None
0.75A 5ef2L-5fubA:
undetectable
5ef2V-5fubA:
undetectable
5ef2L-5fubA:
14.50
5ef2V-5fubA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
4 / 8 SER A 148
GLY A 127
HIS A 153
THR A 154
SAH  A 409 ( 4.2A)
None
None
None
0.76A 5ef3L-5fubA:
undetectable
5ef3V-5fubA:
undetectable
5ef3L-5fubA:
14.50
5ef3V-5fubA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio
rerio)
4 / 5 LEU A 373
LEU A 287
THR A 226
ARG A  99
None
None
EDO  A1414 ( 3.9A)
SAH  A 409 (-2.7A)
0.94A 6ew0F-5fubA:
undetectable
6ew0F-5fubA:
14.04