SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fuk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5fuk MROUPO
(Marasmius
rotula) 		5 / 12 ILE A 123
ALA A 127
ALA A 126
GLN A 128
LEU A 217
 NAG  A1240 ( 4.5A)
None
None
None
None
 1.05A 1fbyA-5fukA:
undetectable		 1fbyA-5fukA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5fuk MROUPO
(Marasmius
rotula) 		5 / 12 ILE A 123
ALA A 127
ALA A 126
GLN A 128
LEU A 217
 NAG  A1240 ( 4.5A)
None
None
None
None
 1.05A 1fbyB-5fukA:
undetectable		 1fbyB-5fukA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5fuk MROUPO
(Marasmius
rotula) 		3 / 3 ASP A  87
ASP A 136
ASN A 100
 None
 0.78A 2bm9D-5fukA:
undetectable		 2bm9D-5fukA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 5fuk MROUPO
(Marasmius
rotula) 		4 / 6 ALA A  59
ILE A 153
GLU A 157
PHE A 160
 PLM  A1237 (-3.5A)
RNP  A1238 ( 4.2A)
HEM  A1235 ( 3.4A)
PLM  A1237 ( 4.0A)
 0.41A 2cizA-5fukA:
26.8		 2cizA-5fukA:
28.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5fuk MROUPO
(Marasmius
rotula) 		4 / 6 LEU A 138
ALA A  88
HIS A 131
ASP A 219
 None
 1.34A 2dpzA-5fukA:
undetectable		 2dpzA-5fukA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 5fuk MROUPO
(Marasmius
rotula) 		4 / 6 LEU A  80
THR A  83
ARG A  68
LEU A 232
 None
 1.10A 2wm3A-5fukA:
undetectable		 2wm3A-5fukA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1436_1
(ORF12)		 5fuk MROUPO
(Marasmius
rotula) 		5 / 9 HIS A   3
LEU A  29
GLY A  45
ALA A  44
LYS A  43
 None
None
HEM  A1235 ( 4.7A)
None
None
 1.39A 2xh9B-5fukA:
undetectable		 2xh9B-5fukA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 5fuk MROUPO
(Marasmius
rotula) 		4 / 6 SER A 125
VAL A 180
THR A 110
THR A 109
 None
 0.91A 3tneA-5fukA:
undetectable		 3tneA-5fukA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 5fuk MROUPO
(Marasmius
rotula) 		4 / 7 VAL A 180
SER A 114
TYR A 121
LEU A  90
 None
None
None
HEM  A1235 (-3.7A)
 0.97A 4hxyB-5fukA:
undetectable		 4hxyB-5fukA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5fuk MROUPO
(Marasmius
rotula) 		4 / 5 ARG A 140
PRO A 142
ILE A  97
ASP A  94
 None
 1.30A 4z4hA-5fukA:
undetectable		 4z4hA-5fukA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5fuk MROUPO
(Marasmius
rotula) 		5 / 12 ILE A 123
ALA A 127
ALA A 126
GLN A 128
LEU A 217
 NAG  A1240 ( 4.5A)
None
None
None
None
 0.99A 5z12C-5fukA:
undetectable		 5z12C-5fukA:
15.42