SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ful'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
4 / 8 SER A 182
GLY A 161
HIS A 187
THR A 188
SAH  A1446 ( 4.4A)
None
None
None
0.76A 1c9sI-5fulA:
undetectable
1c9sJ-5fulA:
undetectable
1c9sI-5fulA:
10.25
1c9sJ-5fulA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
4 / 7 GLY A 161
HIS A 187
THR A 188
SER A 182
None
None
None
SAH  A1446 ( 4.4A)
0.83A 1c9sT-5fulA:
undetectable
1c9sU-5fulA:
undetectable
1c9sT-5fulA:
10.25
1c9sU-5fulA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
4 / 8 GLY A 161
HIS A 187
THR A 188
SER A 182
None
None
None
SAH  A1446 ( 4.4A)
0.81A 1c9sU-5fulA:
undetectable
1c9sV-5fulA:
undetectable
1c9sU-5fulA:
10.25
1c9sV-5fulA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
4 / 7 GLY A 161
HIS A 187
THR A 188
SER A 182
None
None
None
SAH  A1446 ( 4.4A)
0.78A 1gtfL-5fulA:
undetectable
1gtfM-5fulA:
undetectable
1gtfL-5fulA:
10.25
1gtfM-5fulA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
4 / 8 GLY A 161
HIS A 187
THR A 188
SER A 182
None
None
None
SAH  A1446 ( 4.4A)
0.79A 1gtfN-5fulA:
undetectable
1gtfO-5fulA:
undetectable
1gtfN-5fulA:
10.25
1gtfO-5fulA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
5 / 9 ALA A 168
VAL A 176
ILE A 162
VAL A 203
ILE A 201
None
1.09A 1hpvB-5fulA:
undetectable
1hpvB-5fulA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
5 / 12 GLY A 159
THR A 160
ALA A 181
SER A 182
MET A 184
SAH  A1446 ( 3.9A)
None
SAH  A1446 (-3.7A)
SAH  A1446 ( 4.4A)
None
1.30A 1nbiC-5fulA:
6.9
1nbiC-5fulA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
5 / 12 GLY A 159
THR A 160
ALA A 181
SER A 182
MET A 184
SAH  A1446 ( 3.9A)
None
SAH  A1446 (-3.7A)
SAH  A1446 ( 4.4A)
None
1.26A 1nbiD-5fulA:
5.4
1nbiD-5fulA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
5 / 11 LEU A 407
ALA A 257
VAL A 419
LEU A 421
LEU A 261
None
1.14A 1rlbF-5fulA:
undetectable
1rlbF-5fulA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
4 / 8 GLY A 161
HIS A 187
THR A 188
SER A 182
None
None
None
SAH  A1446 ( 4.4A)
0.77A 1utdI-5fulA:
undetectable
1utdJ-5fulA:
undetectable
1utdI-5fulA:
10.25
1utdJ-5fulA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
5 / 12 LEU A 229
MET A 417
LEU A 331
MET A 334
THR A 385
None
1.38A 2aa6A-5fulA:
undetectable
2aa6A-5fulA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
5 / 9 ALA A 168
VAL A 176
ILE A 162
VAL A 203
ILE A 201
None
0.96A 2o4pB-5fulA:
undetectable
2o4pB-5fulA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
3 / 3 LEU A 386
MET A 388
MET A 417
None
1.06A 2vavF-5fulA:
undetectable
2vavF-5fulA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
4 / 5 VAL A 140
TYR A 137
VAL A 221
ASP A 155
None
None
None
SAH  A1446 ( 4.5A)
1.32A 2x45C-5fulA:
undetectable
2x45C-5fulA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
3 / 3 CYH A 167
HIS A 170
PHE A 166
None
1.21A 3cr4X-5fulA:
undetectable
3cr4X-5fulA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
5 / 9 ALA A 241
LEU A 154
LEU A 213
VAL A 211
SER A 164
None
1.22A 3freX-5fulA:
undetectable
3freX-5fulA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
3 / 3 ARG A 133
GLU A 232
ASP A 111
SAH  A1446 (-2.7A)
CA  A1448 ( 4.5A)
None
0.93A 3g2oA-5fulA:
6.9
3g2oA-5fulA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
5 / 11 GLY A 157
GLY A 159
ALA A 181
GLU A 209
ARG A 133
SAH  A1446 (-3.1A)
SAH  A1446 ( 3.9A)
SAH  A1446 (-3.7A)
SAH  A1446 (-3.1A)
SAH  A1446 (-2.7A)
0.98A 3g88A-5fulA:
7.4
3g88A-5fulA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
5 / 12 GLY A 157
GLY A 159
ALA A 181
GLU A 209
ARG A 133
SAH  A1446 (-3.1A)
SAH  A1446 ( 3.9A)
SAH  A1446 (-3.7A)
SAH  A1446 (-3.1A)
SAH  A1446 (-2.7A)
0.95A 3g89A-5fulA:
7.0
3g89A-5fulA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
5 / 11 GLY A 157
GLY A 159
ALA A 181
GLU A 209
ARG A 133
SAH  A1446 (-3.1A)
SAH  A1446 ( 3.9A)
SAH  A1446 (-3.7A)
SAH  A1446 (-3.1A)
SAH  A1446 (-2.7A)
0.95A 3g89B-5fulA:
7.4
3g89B-5fulA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
5 / 12 GLY A 157
GLY A 159
ALA A 181
GLU A 209
ARG A 133
SAH  A1446 (-3.1A)
SAH  A1446 ( 3.9A)
SAH  A1446 (-3.7A)
SAH  A1446 (-3.1A)
SAH  A1446 (-2.7A)
0.95A 3g8bA-5fulA:
7.5
3g8bA-5fulA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
5 / 12 GLY A 157
GLY A 159
ALA A 181
GLU A 209
ARG A 133
SAH  A1446 (-3.1A)
SAH  A1446 ( 3.9A)
SAH  A1446 (-3.7A)
SAH  A1446 (-3.1A)
SAH  A1446 (-2.7A)
0.98A 3g8bB-5fulA:
7.2
3g8bB-5fulA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
4 / 6 GLY A 159
THR A 160
GLU A 180
ASP A 155
SAH  A1446 ( 3.9A)
None
SAH  A1446 (-2.7A)
SAH  A1446 ( 4.5A)
0.96A 3ps9A-5fulA:
5.7
3ps9A-5fulA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
4 / 5 HIS A 381
THR A 227
GLU A 223
ASP A 155
None
None
CA  A1448 (-4.2A)
SAH  A1446 ( 4.5A)
1.10A 3tm4A-5fulA:
8.8
3tm4A-5fulA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
4 / 5 HIS A 381
THR A 227
GLU A 223
ASP A 155
None
None
CA  A1448 (-4.2A)
SAH  A1446 ( 4.5A)
1.13A 3tm4B-5fulA:
8.6
3tm4B-5fulA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
4 / 6 GLY A 159
GLU A 180
ASP A 155
GLU A 209
SAH  A1446 ( 3.9A)
SAH  A1446 (-2.7A)
SAH  A1446 ( 4.5A)
SAH  A1446 (-3.1A)
0.82A 3vywC-5fulA:
6.4
3vywC-5fulA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
3 / 3 VAL A 400
THR A 402
ARG A 339
None
0.59A 5b2sB-5fulA:
undetectable
5b2sB-5fulA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
3 / 3 VAL A 400
THR A 402
ARG A 339
None
0.59A 5b2tB-5fulA:
undetectable
5b2tB-5fulA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
4 / 8 SER A 182
GLY A 161
HIS A 187
THR A 188
SAH  A1446 ( 4.4A)
None
None
None
0.76A 5eevL-5fulA:
undetectable
5eevV-5fulA:
undetectable
5eevL-5fulA:
10.25
5eevV-5fulA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
4 / 8 SER A 182
GLY A 161
HIS A 187
THR A 188
SAH  A1446 ( 4.4A)
None
None
None
0.76A 5eewL-5fulA:
undetectable
5eewV-5fulA:
undetectable
5eewL-5fulA:
10.25
5eewV-5fulA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
4 / 8 SER A 182
GLY A 161
HIS A 187
THR A 188
SAH  A1446 ( 4.4A)
None
None
None
0.76A 5eezL-5fulA:
undetectable
5eezV-5fulA:
undetectable
5eezL-5fulA:
10.25
5eezV-5fulA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
4 / 8 SER A 182
GLY A 161
HIS A 187
THR A 188
SAH  A1446 ( 4.4A)
None
None
None
0.76A 5ef1L-5fulA:
undetectable
5ef1V-5fulA:
undetectable
5ef1L-5fulA:
10.25
5ef1V-5fulA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
4 / 8 SER A 182
GLY A 161
HIS A 187
THR A 188
SAH  A1446 ( 4.4A)
None
None
None
0.76A 5ef2L-5fulA:
undetectable
5ef2V-5fulA:
undetectable
5ef2L-5fulA:
10.25
5ef2V-5fulA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
4 / 8 SER A 182
GLY A 161
HIS A 187
THR A 188
SAH  A1446 ( 4.4A)
None
None
None
0.76A 5ef3L-5fulA:
undetectable
5ef3V-5fulA:
undetectable
5ef3L-5fulA:
10.25
5ef3V-5fulA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
3 / 3 LYS A 273
TRP A 277
SER A 272
None
0.87A 5nwwA-5fulA:
undetectable
5nwwA-5fulA:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus
musculus)
5 / 12 MET A 334
VAL A 419
PHE A 387
THR A 227
GLY A 226
None
None
None
None
CA  A1448 ( 4.2A)
1.21A 6brdA-5fulA:
undetectable
6brdA-5fulA:
9.89