SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fur'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 6
(Homo
sapiens) 		4 / 6 HIS J 422
ALA J 378
GLY J 375
TYR J 374
 None
 1.13A 1c8lA-5furJ:
undetectable		 1c8lA-5furJ:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		4 / 5 THR I 342
THR I 281
HIS I 267
LEU I 330
 None
 1.02A 1d4fC-5furI:
undetectable		 1d4fC-5furI:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 6
(Homo
sapiens) 		4 / 5 ARG J 335
ALA J 338
ASP J 331
GLY J 379
 None
 0.97A 1e7bA-5furJ:
2.2		 1e7bA-5furJ:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 6
(Homo
sapiens) 		4 / 7 PHE J 344
LEU J 336
VAL J 286
LEU J 297
 None
 0.98A 1hk3A-5furJ:
undetectable		 1hk3A-5furJ:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		5 / 12 GLY I 573
SER I 574
GLN I 650
ARG I 654
ASP I 646
 None
 0.95A 1i9gA-5furI:
undetectable		 1i9gA-5furI:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		4 / 7 GLN I 352
LEU I 284
SER I 323
ASN I 328
 None
 1.25A 1ig3A-5furI:
undetectable
1ig3B-5furI:
undetectable		 1ig3A-5furI:
12.06
1ig3B-5furI:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		4 / 7 GLN I 662
ASP I 658
LEU I 399
SER I 665
 None
 1.26A 1ig3A-5furI:
undetectable
1ig3B-5furI:
undetectable		 1ig3A-5furI:
12.06
1ig3B-5furI:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		3 / 3 ARG I 361
ILE I 417
TRP I 368
 None
 1.14A 1nodB-5furI:
undetectable		 1nodB-5furI:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OAF_A_ASCA1253_0
(ASCORBATE PEROXIDASE)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		4 / 6 CYH I 269
PRO I 271
LEU I 270
HIS I 176
 None
 1.26A 1oafA-5furI:
undetectable		 1oafA-5furI:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		4 / 6 PRO G 813
MET G 912
ALA G 915
GLU G 916
 None
 1.44A 1qhyA-5furG:
undetectable		 1qhyA-5furG:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		3 / 3 GLN G 905
HIS G 823
ARG G 825
 None
 0.98A 1zlqA-5furG:
undetectable		 1zlqA-5furG:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		4 / 6 LEU I  60
ASN I  66
GLN I  31
ILE I  53
 None
 1.16A 2jn3A-5furI:
undetectable		 2jn3A-5furI:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		4 / 8 TYR G 909
HIS G 858
SER G 857
HIS G 627
 None
 1.25A 2vmyA-5furG:
undetectable
2vmyB-5furG:
undetectable		 2vmyA-5furG:
11.09
2vmyB-5furG:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 5fur TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT 1
(Homo
sapiens) 		4 / 6 MET C 358
LYS C 369
PHE C 367
ILE C 366
 None
 1.39A 2w98B-5furC:
undetectable		 2w98B-5furC:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5fur TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT 2
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ILE C 342
ARG D  66
THR D  64
LEU D  62
 None
 1.00A 3ag1N-5furC:
undetectable
3ag1W-5furC:
undetectable		 3ag1N-5furC:
6.86
3ag1W-5furC:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 6
(Homo
sapiens) 		4 / 6 HIS J 422
ALA J 378
GLY J 375
TYR J 374
 None
 1.14A 3ddsA-5furJ:
undetectable		 3ddsA-5furJ:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		5 / 12 PHE G 751
GLY G 804
PHE G1091
ASP G1092
HIS G 756
 None
 1.39A 3dlcA-5furG:
undetectable		 3dlcA-5furG:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		4 / 7 LEU I 667
GLU I 664
ASP I 400
SER I 697
 None
 1.28A 3dzgA-5furI:
undetectable		 3dzgA-5furI:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		4 / 7 LEU I 667
GLU I 664
ASP I 400
SER I 697
 None
 1.27A 3dzgB-5furI:
undetectable		 3dzgB-5furI:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5fur TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT 2
(Homo
sapiens) 		4 / 4 ILE D  44
GLN D   4
ILE C 357
LEU D  34
 None
 1.22A 3dzyD-5furD:
undetectable		 3dzyD-5furD:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		4 / 7 ARG G 890
ILE G 897
TRP G 837
GLU G 895
 None
 1.48A 3e7gA-5furG:
undetectable
3e7gB-5furG:
undetectable		 3e7gA-5furG:
12.64
3e7gB-5furG:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		4 / 7 GLU G 895
ARG G 890
ILE G 897
TRP G 837
 None
 1.47A 3e7gA-5furG:
undetectable
3e7gB-5furG:
undetectable		 3e7gA-5furG:
12.64
3e7gB-5furG:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		4 / 7 ARG G 890
ILE G 897
TRP G 837
GLU G 895
 None
 1.47A 3e7gC-5furG:
undetectable
3e7gD-5furG:
undetectable		 3e7gC-5furG:
12.64
3e7gD-5furG:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		4 / 8 GLU G 895
ARG G 890
ILE G 897
TRP G 837
 None
 1.44A 3e7gC-5furG:
undetectable
3e7gD-5furG:
undetectable		 3e7gC-5furG:
12.64
3e7gD-5furG:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		5 / 12 GLU G 674
ASN I 509
GLY G 680
MET G 683
PHE G 685
 None
 1.33A 3g1uA-5furG:
undetectable		 3g1uA-5furG:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		3 / 3 THR I 280
LYS I 371
GLU I 338
 None
 1.02A 3ijdB-5furI:
undetectable		 3ijdB-5furI:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 6
(Homo
sapiens) 		5 / 12 ARG J 373
PRO J 369
THR J 371
ARG J 315
LEU J 317
 None
 1.36A 3iv6C-5furJ:
undetectable		 3iv6C-5furJ:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 5fur TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT 2
(Homo
sapiens;
Homo
sapiens) 		3 / 3 LEU B  42
TRP B  46
GLY D  12
 None
 0.79A 3l35A-5furB:
undetectable
3l35H-5furB:
undetectable		 3l35A-5furB:
17.02
3l35H-5furB:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 5fur TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT 2
(Homo
sapiens;
Homo
sapiens) 		3 / 3 LEU B  42
TRP B  46
GLY D  12
 None
 0.75A 3l35B-5furB:
undetectable
3l35K-5furB:
undetectable		 3l35B-5furB:
17.02
3l35K-5furB:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 6
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 8
(Homo
sapiens;
Homo
sapiens) 		4 / 7 LEU L 175
ASP J 249
ARG L 176
ALA L 179
 None
 1.15A 3mbgA-5furL:
undetectable
3mbgB-5furL:
undetectable		 3mbgA-5furL:
17.10
3mbgB-5furL:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		5 / 12 SER I 321
SER I 349
LEU I 330
THR I 306
VAL I 287
 None
 1.22A 3mbhB-5furI:
undetectable		 3mbhB-5furI:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		5 / 12 SER I 321
SER I 349
LEU I 330
THR I 306
VAL I 287
 None
 1.24A 3mbhC-5furI:
undetectable		 3mbhC-5furI:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_D_PXLD400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		5 / 12 SER I 321
SER I 349
LEU I 330
THR I 306
VAL I 287
 None
 1.24A 3mbhD-5furI:
undetectable		 3mbhD-5furI:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_E_PXLE400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		5 / 12 SER I 321
SER I 349
LEU I 330
THR I 306
VAL I 287
 None
 1.23A 3mbhE-5furI:
undetectable		 3mbhE-5furI:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		5 / 10 ILE G 721
ILE G 773
ASP G 799
ILE G 700
LEU G 775
 None
 1.04A 3o1cA-5furG:
undetectable		 3o1cA-5furG:
4.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 7
(Homo
sapiens) 		4 / 5 LEU H  63
SER H  65
LEU H  20
PRO H  21
 None
 1.29A 3onnA-5furH:
undetectable		 3onnA-5furH:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		5 / 10 ILE G 721
ILE G 773
ASP G 799
ILE G 700
LEU G 775
 None
 1.08A 3qgzA-5furG:
undetectable		 3qgzA-5furG:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		3 / 3 PHE I 308
CYH I 269
HIS I 267
 None
 1.31A 3u9fF-5furI:
undetectable		 3u9fF-5furI:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5fur TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT 2
(Homo
sapiens) 		5 / 10 ILE C 366
THR D  10
SER D  14
ILE C 357
THR B   9
 None
 1.28A 3um5B-5furC:
undetectable		 3um5B-5furC:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		4 / 8 ARG I 361
PHE I 503
GLY I 502
MET I 469
 None
 0.93A 3v3nB-5furI:
undetectable		 3v3nB-5furI:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		4 / 8 ARG I 361
PHE I 503
GLY I 502
MET I 469
 None
 0.93A 3v3nC-5furI:
undetectable		 3v3nC-5furI:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		4 / 6 CYH I 297
THR I 296
ASN I 474
ILE I 377
 None
 1.40A 3w9tB-5furI:
undetectable		 3w9tB-5furI:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 7
(Homo
sapiens;
Homo
sapiens) 		4 / 4 GLU G 682
ASP H  81
ARG G 687
THR H  84
 None
 1.43A 4ej1A-5furG:
undetectable		 4ej1A-5furG:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 5fur TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT 2
(Homo
sapiens) 		5 / 11 ILE D  44
GLN D  50
ALA D  49
LEU D  48
LEU B  13
 None
 1.06A 4g1bB-5furD:
4.1		 4g1bB-5furD:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 7
(Homo
sapiens;
Homo
sapiens) 		4 / 5 VAL H 143
ARG H 146
GLU G 982
LEU G1098
 None
 1.42A 4hojA-5furH:
undetectable		 4hojA-5furH:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		4 / 7 THR I 752
LEU I 667
GLN I 652
LEU I 653
 None
 0.98A 4ib4A-5furI:
undetectable		 4ib4A-5furI:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		3 / 3 LYS I 704
LEU I 759
ALA I 706
 None
 0.72A 4iizA-5furI:
1.8		 4iizA-5furI:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		3 / 3 ARG G 687
GLU G 674
ASN I 509
 None
 0.75A 4imaD-5furG:
undetectable		 4imaD-5furG:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		3 / 3 ARG G 687
GLU G 674
ASN I 509
 None
 0.78A 4ip7D-5furG:
undetectable		 4ip7D-5furG:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		3 / 3 ARG G 795
LEU G 797
GLU G 796
 None
 0.74A 4l3gF-5furG:
undetectable		 4l3gF-5furG:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		4 / 6 THR I 752
LEU I 667
GLN I 652
LEU I 653
 None
 0.96A 4nc3A-5furI:
undetectable		 4nc3A-5furI:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		4 / 7 GLU G 895
ARG G 890
ILE G 897
TRP G 837
 None
 1.46A 4nosA-5furG:
undetectable
4nosB-5furG:
undetectable		 4nosA-5furG:
13.25
4nosB-5furG:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		4 / 6 GLU G 895
ARG G 890
ILE G 897
TRP G 837
 None
 1.44A 4nosC-5furG:
undetectable
4nosD-5furG:
undetectable		 4nosC-5furG:
13.25
4nosD-5furG:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 7
(Homo
sapiens;
Homo
sapiens) 		5 / 12 VAL G 803
LEU G 775
LEU G 797
LEU G 784
ALA H  89
 None
 1.22A 4rtbA-5furG:
undetectable		 4rtbA-5furG:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		3 / 3 THR I 807
ASN I 804
SER I 805
 None
 0.73A 4tvtA-5furI:
undetectable		 4tvtA-5furI:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		3 / 3 ALA G 871
TRP G 883
VAL G 884
 None
 0.34A 4w9nC-5furG:
undetectable		 4w9nC-5furG:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		3 / 3 GLU I 398
ILE I 377
ALA I 453
 None
 0.56A 4wnwB-5furI:
undetectable		 4wnwB-5furI:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 5fur TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT 2
(Homo
sapiens) 		5 / 11 ASP C 364
ALA D  47
TYR B  14
GLY C 356
VAL D  52
 None
 1.13A 4xnxA-5furC:
undetectable		 4xnxA-5furC:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 6
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 8
(Homo
sapiens;
Homo
sapiens;
Homo
sapiens) 		3 / 3 SER I 853
GLU L 177
GLU J 226
 None
 0.76A 4ymgB-5furI:
undetectable		 4ymgB-5furI:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 6
(Homo
sapiens) 		4 / 4 LEU J 304
ARG J 354
ILE J 305
ILE J 351
 None
 1.29A 5dzk2-5furJ:
undetectable
5dzkM-5furJ:
undetectable
5dzkN-5furJ:
undetectable		 5dzk2-5furJ:
5.13
5dzkM-5furJ:
13.74
5dzkN-5furJ:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE G 944
GLU G 916
ARG G 957
ALA G 958
SER G 817
 None
 1.05A 5ih0A-5furG:
undetectable		 5ih0A-5furG:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		5 / 11 ASN I 246
VAL I 498
SER I 360
THR I 242
LEU I 476
 None
 1.45A 5jh7D-5furI:
undetectable		 5jh7D-5furI:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 5fur TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT 2
(Homo
sapiens) 		5 / 11 ALA D  97
GLY C 356
ILE C 357
VAL D  93
ILE D  95
 None
 1.25A 5kr2B-5furD:
undetectable		 5kr2B-5furD:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		3 / 3 THR I 567
PRO I 632
ASP I 633
 None
 0.93A 5l8dB-5furI:
undetectable		 5l8dB-5furI:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		3 / 3 THR I 567
PRO I 632
ASP I 633
 None
 0.93A 5mwuB-5furI:
undetectable		 5mwuB-5furI:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		4 / 6 PHE I 647
TRP I 627
ARG I 654
GLY I 573
 None
 1.04A 5o4yA-5furI:
undetectable		 5o4yA-5furI:
1.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 6
(Homo
sapiens) 		4 / 6 ASN J 275
LEU J 278
ARG J 268
GLY J 266
 None
 1.06A 5o4yA-5furJ:
undetectable		 5o4yA-5furJ:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		4 / 9 ILE I 507
ILE I 373
ILE I 377
LEU I 380
 None
 0.74A 5vkqB-5furI:
undetectable
5vkqC-5furI:
undetectable		 5vkqB-5furI:
20.99
5vkqC-5furI:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 6
(Homo
sapiens) 		5 / 12 GLN J 424
ALA J 420
GLU J 399
LEU J 396
ILE J 392
 None
 1.31A 5vlmB-5furJ:
3.4		 5vlmB-5furJ:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		3 / 3 HIS I 593
GLU I 570
ASN I 599
 None
 0.95A 5wbvA-5furI:
undetectable		 5wbvA-5furI:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		3 / 3 HIS I 593
GLU I 570
ASN I 599
 None
 0.95A 5wbvB-5furI:
0.9		 5wbvB-5furI:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9A_A_AR3A201_1
(PEPTIDYL-TRNA
HYDROLASE)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens) 		4 / 6 ALA I 351
GLN I 352
LYS I 371
GLN I 450
 None
 1.43A 5y9aA-5furI:
undetectable		 5y9aA-5furI:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)		 5fur TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT 2
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ALA D  97
GLY C 356
ILE C 357
VAL D  93
ILE D  95
 None
 1.17A 6difA-5furD:
undetectable		 6difA-5furD:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 6
(Homo
sapiens) 		4 / 6 THR J 372
ARG J 330
GLN J 316
ARG J 315
 None
 1.15A 6ef6A-5furJ:
undetectable		 6ef6A-5furJ:
18.60