SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fus'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CTR_A_TFPA153_1
(CALMODULIN)		 5fus PUTATIVE ENOYL COA
HYDRATASE
(Burkholderia
cenocepacia) 		5 / 9 GLU A 158
ILE A 203
LEU A 202
ALA A 140
VAL A 146
 None
 1.11A 1ctrA-5fusA:
undetectable		 1ctrA-5fusA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 5fus PUTATIVE ENOYL COA
HYDRATASE
(Burkholderia
cenocepacia) 		5 / 12 ALA A 140
GLY A 169
GLY A 134
GLY A 136
LEU A 185
 None
 0.94A 1eizA-5fusA:
undetectable		 1eizA-5fusA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 5fus PUTATIVE ENOYL COA
HYDRATASE
(Burkholderia
cenocepacia) 		5 / 12 ALA A 140
GLY A 169
GLY A 134
GLY A 136
LEU A 185
 None
 0.94A 1ej0A-5fusA:
undetectable		 1ej0A-5fusA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 5fus PUTATIVE ENOYL COA
HYDRATASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A  85
GLY A 136
MET A 167
PHE A 161
LEU A 163
 None
None
DAO  A1285 (-4.2A)
None
None
 1.38A 2w8yA-5fusA:
undetectable		 2w8yA-5fusA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 5fus PUTATIVE ENOYL COA
HYDRATASE
(Burkholderia
cenocepacia) 		3 / 3 THR A 188
SER A 184
PHE A 137
 None
 0.78A 3d4sA-5fusA:
undetectable		 3d4sA-5fusA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 5fus PUTATIVE ENOYL COA
HYDRATASE
(Burkholderia
cenocepacia) 		4 / 8 VAL A 146
VAL A 173
TYR A 197
VAL A 128
 None
 0.89A 3fhxB-5fusA:
undetectable		 3fhxB-5fusA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 5fus PUTATIVE ENOYL COA
HYDRATASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A 117
ALA A 139
ALA A 140
PHE A  68
TRP A  69
 GOL  A1280 ( 3.7A)
DAO  A1285 ( 4.0A)
None
None
None
 1.05A 3p2kC-5fusA:
undetectable		 3p2kC-5fusA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 5fus PUTATIVE ENOYL COA
HYDRATASE
(Burkholderia
cenocepacia) 		5 / 9 GLU A 129
GLY A 130
VAL A 152
GLU A 138
GLY A 155
 None
None
None
DAO  A1285 ( 4.6A)
None
 1.19A 4fimA-5fusA:
undetectable		 4fimA-5fusA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 5fus PUTATIVE ENOYL COA
HYDRATASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A 163
PHE A  88
PRO A 165
ASP A  84
GLY A  82
 None
DAO  A1285 (-3.4A)
None
None
DAO  A1285 ( 4.6A)
 1.35A 4j7xF-5fusA:
2.1		 4j7xF-5fusA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 5fus PUTATIVE ENOYL COA
HYDRATASE
(Burkholderia
cenocepacia) 		4 / 8 ALA A 139
PHE A  44
GLY A 136
ALA A 132
 DAO  A1285 ( 4.0A)
DAO  A1285 (-3.5A)
None
None
 0.65A 4zjzA-5fusA:
undetectable		 4zjzA-5fusA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 5fus PUTATIVE ENOYL COA
HYDRATASE
(Burkholderia
cenocepacia) 		4 / 7 ALA A 212
THR A 216
ILE A 125
ALA A 126
 None
 0.84A 6ma7A-5fusA:
undetectable		 6ma7A-5fusA:
13.94