SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fuu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 5fuu HIV-1 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		3 / 3 GLN A 428
TYR A 384
ARG A 419
 None
 0.70A 1gtbA-5fuuA:
undetectable		 1gtbA-5fuuA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 5fuu HIV-1 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		3 / 3 GLU A  91
TRP A  45
LYS A 282
 None
 1.44A 1qu2A-5fuuA:
undetectable		 1qu2A-5fuuA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5fuu HIV-1 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 ILE A 215
ALA A  55
LEU A  52
LEU A 483
ILE A 251
 None
 1.09A 1ra3A-5fuuA:
undetectable		 1ra3A-5fuuA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 5fuu HIV-1 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		4 / 6 ILE A 423
SER A 195
ARG A 192
PHE A 176
 None
 0.96A 2q72A-5fuuA:
undetectable		 2q72A-5fuuA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 5fuu HIV-1 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		4 / 7 ILE A 423
SER A 195
ARG A 192
PHE A 176
 None
 0.96A 2qb4A-5fuuA:
undetectable		 2qb4A-5fuuA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 5fuu HIV-1 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		4 / 4 THR A  37
VAL A  42
GLY B 531
THR B 529
 None
 1.09A 3cflA-5fuuA:
undetectable		 3cflA-5fuuA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 5fuu HIV-1 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		3 / 3 SER A 375
PHE A 382
LYS A 421
 None
 1.00A 3u88A-5fuuA:
undetectable		 3u88A-5fuuA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 5fuu HIV-1 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		4 / 6 ILE A 371
TRP A 112
ILE A 108
MET A 475
 None
 1.42A 3welA-5fuuA:
undetectable		 3welA-5fuuA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5fuu HIV-1 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 11 ILE A 215
ALA A  55
LEU A  52
LEU A 483
ILE A 251
 None
 1.12A 4p66A-5fuuA:
undetectable		 4p66A-5fuuA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 5fuu HIV-1 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		4 / 6 ILE A 420
PHE A 383
ARG A 298
ILE A 439
 None
None
None
MAN  A1268 (-3.4A)
 1.27A 4zzcA-5fuuA:
undetectable
4zzcB-5fuuA:
undetectable		 4zzcA-5fuuA:
18.92
4zzcB-5fuuA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 5fuu HIV-1 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		4 / 6 ILE A 420
PHE A 383
ARG A 298
ILE A 439
 None
None
None
MAN  A1268 (-3.4A)
 1.32A 4zzcB-5fuuA:
undetectable
4zzcC-5fuuA:
undetectable		 4zzcB-5fuuA:
18.92
4zzcC-5fuuA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5fuu HIV-1 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		3 / 3 VAL A 254
SER A 481
MET A 100
 None
 0.67A 5ikqA-5fuuA:
undetectable		 5ikqA-5fuuA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5fuu HIV-1 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		4 / 6 PHE A 468
LEU A 452
ARG A 469
GLY A 471
 None
None
NAG  A1362 ( 4.4A)
None
 1.09A 5o4yA-5fuuA:
undetectable		 5o4yA-5fuuA:
3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 5fuu HIV-1 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 9 SER A 481
THR A 450
GLY A 451
LEU A 261
SER A 256
 None
None
None
NAG  A1262 ( 4.2A)
None
 1.28A 5vw4A-5fuuA:
undetectable		 5vw4A-5fuuA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 5fuu HIV-1 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		4 / 7 LEU B 523
ALA B 525
ALA B 526
THR B 627
 None
 0.89A 6a7jA-5fuuB:
undetectable		 6a7jA-5fuuB:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 5fuu HIV-1 ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		3 / 3 ILE A 161
THR A 162
PRO A 124
 None
 0.61A 6ncsA-5fuuA:
undetectable		 6ncsA-5fuuA:
19.23