SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fuz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5fuz 645 FAB, HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL H 171
VAL H 190
SER H 188
ASN H 205
ASN H 163
 None
 1.44A 2y03A-5fuzH:
undetectable		 2y03A-5fuzH:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5fuz 645 FAB, HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL H 171
VAL H 190
SER H 188
ASN H 205
ASN H 163
 None
 1.49A 2y03B-5fuzH:
undetectable		 2y03B-5fuzH:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 5fuz 645 FAB, HEAVY CHAIN
(Homo
sapiens) 		4 / 5 TYR H  32
ILE H  27
LEU H   4
LEU H 110
 None
 1.18A 2zb7A-5fuzH:
undetectable		 2zb7A-5fuzH:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5fuz 645 FAB, HEAVY CHAIN
(Homo
sapiens) 		4 / 8 SER H  21
SER H   7
GLY H  10
GLY H 114
 None
 0.88A 4fo4B-5fuzH:
undetectable		 4fo4B-5fuzH:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 5fuz 645 FAB, HEAVY CHAIN
(Homo
sapiens) 		5 / 10 PHE H 130
GLY H 126
THR H 213
VAL H 206
VAL H 215
 None
 1.21A 4jx1B-5fuzH:
undetectable		 4jx1B-5fuzH:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		 5fuz 645 FAB, HEAVY CHAIN
(Homo
sapiens) 		5 / 10 VAL H 171
VAL H 190
SER H 188
ASN H 205
ASN H 163
 None
 1.49A 4ldoA-5fuzH:
undetectable		 4ldoA-5fuzH:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 5fuz 645 FAB, HEAVY CHAIN
(Homo
sapiens) 		4 / 8 ASP H 109
ARG H  97
PRO H 106
TRP H  47
 None
 1.17A 4uhxA-5fuzH:
undetectable		 4uhxA-5fuzH:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 5fuz 645 FAB, HEAVY CHAIN
(Homo
sapiens) 		4 / 8 ASP H 109
ARG H  97
PRO H 106
TRP H  47
 None
 1.17A 4uhxA-5fuzH:
undetectable		 4uhxA-5fuzH:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA606_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5fuz 645 FAB, HEAVY CHAIN
(Homo
sapiens) 		4 / 5 GLU H 156
PHE H 154
HIS H 208
THR H 118
 None
 1.16A 6b58A-5fuzH:
undetectable		 6b58A-5fuzH:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 5fuz 645 FAB, HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL H 171
VAL H 190
SER H 188
ASN H 205
ASN H 163
 None
 1.44A 6h7mB-5fuzH:
undetectable		 6h7mB-5fuzH:
18.06