SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fv0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_0
(N,N-DIMETHYLGLYCINE
OXIDASE)		 5fv0 ESSC
(Geobacillus
thermodenitrific
ans) 		5 / 12 MET A1011
LEU A1015
TYR A1030
PHE A1052
PHE A1066
 None
 1.47A 1pj7A-5fv0A:
undetectable		 1pj7A-5fv0A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5fv0 ESSC
(Geobacillus
thermodenitrific
ans) 		4 / 6 VAL A1410
LEU A1281
MET A1398
SER A1402
 None
 0.82A 1wrlB-5fv0A:
undetectable		 1wrlB-5fv0A:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 5fv0 ESSC
(Geobacillus
thermodenitrific
ans) 		4 / 4 LEU A1319
PRO A1476
ILE A1297
LEU A1298
 None
 1.12A 1ya4C-5fv0A:
undetectable		 1ya4C-5fv0A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5fv0 ESSC
(Geobacillus
thermodenitrific
ans) 		4 / 8 PHE A1409
GLY A1412
THR A1425
PHE A1417
 None
 1.06A 1ykiA-5fv0A:
undetectable
1ykiB-5fv0A:
undetectable		 1ykiA-5fv0A:
17.65
1ykiB-5fv0A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5fv0 ESSC
(Geobacillus
thermodenitrific
ans) 		4 / 8 THR A1425
PHE A1417
PHE A1409
GLY A1412
 None
 1.05A 1ykiA-5fv0A:
undetectable
1ykiB-5fv0A:
undetectable		 1ykiA-5fv0A:
17.65
1ykiB-5fv0A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5fv0 ESSC
(Geobacillus
thermodenitrific
ans) 		4 / 8 PHE A1409
GLY A1412
THR A1425
PHE A1417
 None
 1.06A 1ykiC-5fv0A:
undetectable
1ykiD-5fv0A:
undetectable		 1ykiC-5fv0A:
17.65
1ykiD-5fv0A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5fv0 ESSC
(Geobacillus
thermodenitrific
ans) 		4 / 8 THR A1425
PHE A1417
PHE A1409
GLY A1412
 None
 1.03A 1ykiC-5fv0A:
undetectable
1ykiD-5fv0A:
undetectable		 1ykiC-5fv0A:
17.65
1ykiD-5fv0A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5fv0 ESSC
(Geobacillus
thermodenitrific
ans) 		5 / 10 PHE A1032
PHE A1034
VAL A1110
ILE A1060
LEU A1121
 None
 0.98A 1z11D-5fv0A:
undetectable		 1z11D-5fv0A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 5fv0 ESSC
(Geobacillus
thermodenitrific
ans) 		4 / 4 LEU A1236
PRO A1237
LEU A1262
ARG A1268
 None
 1.07A 2hrcA-5fv0A:
undetectable		 2hrcA-5fv0A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5fv0 ESSC
(Geobacillus
thermodenitrific
ans) 		5 / 12 PHE A1406
MET A1397
VAL A1372
THR A1386
LEU A1337
 None
 1.31A 2x2nC-5fv0A:
undetectable		 2x2nC-5fv0A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 5fv0 ESSC
(Geobacillus
thermodenitrific
ans) 		4 / 6 ASN A1036
SER A1037
ALA A1038
ASP A1105
 ONA  A2480 ( 4.3A)
None
ONA  A2480 ( 4.0A)
ONA  A2480 (-3.3A)
 1.24A 3aruA-5fv0A:
2.1		 3aruA-5fv0A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5fv0 ESSC
(Geobacillus
thermodenitrific
ans) 		5 / 9 GLY A1261
VAL A1270
ILE A1435
VAL A1293
VAL A1296
 None
 1.46A 3fi0O-5fv0A:
undetectable		 3fi0O-5fv0A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5fv0 ESSC
(Geobacillus
thermodenitrific
ans) 		4 / 4 LEU A1236
PRO A1237
LEU A1262
ARG A1268
 None
 1.04A 3hcoB-5fv0A:
2.5		 3hcoB-5fv0A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5fv0 ESSC
(Geobacillus
thermodenitrific
ans) 		4 / 4 LEU A1027
MET A1067
ILE A 999
ASP A1033
 None
 1.38A 3hecA-5fv0A:
undetectable		 3hecA-5fv0A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 5fv0 ESSC
(Geobacillus
thermodenitrific
ans) 		4 / 5 PHE A1135
PHE A1107
ALA A1139
LEU A1153
 None
 1.10A 3t3zC-5fv0A:
undetectable		 3t3zC-5fv0A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5fv0 ESSC
(Geobacillus
thermodenitrific
ans) 		4 / 5 SER A1441
ASP A1470
ASP A1263
ILE A1473
 None
 1.34A 3uj7B-5fv0A:
undetectable		 3uj7B-5fv0A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 5fv0 ESSC
(Geobacillus
thermodenitrific
ans) 		5 / 12 GLY A1261
ILE A1475
PHE A1464
GLN A1471
ILE A1258
 None
 0.78A 4ax8A-5fv0A:
4.2		 4ax8A-5fv0A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 5fv0 ESSC
(Geobacillus
thermodenitrific
ans) 		5 / 11 ILE A1297
ILE A1272
ALA A1434
ILE A1475
VAL A1293
 None
 1.04A 4h1nA-5fv0A:
undetectable		 4h1nA-5fv0A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5fv0 ESSC
(Geobacillus
thermodenitrific
ans) 		5 / 12 LEU A1341
ILE A1394
MET A1398
GLY A1310
LEU A1337
 None
 0.84A 4lmnA-5fv0A:
undetectable		 4lmnA-5fv0A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 5fv0 ESSC
(Geobacillus
thermodenitrific
ans) 		4 / 6 ILE A1145
PHE A1107
ILE A1122
GLU A1118
 None
 1.41A 4zzcA-5fv0A:
undetectable
4zzcB-5fv0A:
undetectable		 4zzcA-5fv0A:
21.70
4zzcB-5fv0A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5fv0 ESSC
(Geobacillus
thermodenitrific
ans) 		3 / 3 LEU A1311
PHE A1374
ILE A1331
 None
 0.69A 5dzk1-5fv0A:
undetectable
5dzkF-5fv0A:
undetectable
5dzkM-5fv0A:
undetectable		 5dzk1-5fv0A:
3.77
5dzkF-5fv0A:
16.54
5dzkM-5fv0A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 5fv0 ESSC
(Geobacillus
thermodenitrific
ans) 		3 / 3 GLY A1420
GLN A1383
LYS A1429
 None
 0.98A 5imsB-5fv0A:
2.6		 5imsB-5fv0A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 5fv0 ESSC
(Geobacillus
thermodenitrific
ans) 		4 / 7 TYR A 987
ILE A 973
ILE A1197
ILE A 999
 None
 0.93A 5murB-5fv0A:
undetectable		 5murB-5fv0A:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5fv0 ESSC
(Geobacillus
thermodenitrific
ans) 		5 / 12 ILE A1282
HIS A1279
VAL A1408
PHE A1374
VAL A1373
 None
 1.07A 5n0oA-5fv0A:
undetectable		 5n0oA-5fv0A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5fv0 ESSC
(Geobacillus
thermodenitrific
ans) 		5 / 12 ILE A1282
HIS A1279
VAL A1408
PHE A1374
VAL A1373
 None
 1.08A 5n0rA-5fv0A:
undetectable		 5n0rA-5fv0A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5fv0 ESSC
(Geobacillus
thermodenitrific
ans) 		5 / 12 ILE A1282
HIS A1279
VAL A1408
PHE A1374
VAL A1373
 None
 1.09A 5n0sA-5fv0A:
undetectable		 5n0sA-5fv0A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5fv0 ESSC
(Geobacillus
thermodenitrific
ans) 		5 / 12 ILE A1282
HIS A1279
VAL A1408
PHE A1374
VAL A1373
 None
 1.10A 5n0sB-5fv0A:
undetectable		 5n0sB-5fv0A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5fv0 ESSC
(Geobacillus
thermodenitrific
ans) 		5 / 12 ILE A1282
HIS A1279
VAL A1408
PHE A1374
VAL A1373
 None
 1.12A 5n0wA-5fv0A:
undetectable		 5n0wA-5fv0A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5fv0 ESSC
(Geobacillus
thermodenitrific
ans) 		5 / 12 ILE A1282
HIS A1279
VAL A1408
PHE A1374
VAL A1373
 None
 1.10A 5n4iA-5fv0A:
2.9		 5n4iA-5fv0A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 5fv0 ESSC
(Geobacillus
thermodenitrific
ans) 		3 / 3 VAL A1437
LYS A1477
MET A1242
 None
 0.96A 5nknA-5fv0A:
undetectable		 5nknA-5fv0A:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 5fv0 ESSC
(Geobacillus
thermodenitrific
ans) 		4 / 8 LEU A1319
TYR A1322
GLU A1299
THR A1291
 None
 1.17A 6c71B-5fv0A:
undetectable		 6c71B-5fv0A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5fv0 ESSC
(Geobacillus
thermodenitrific
ans) 		3 / 3 GLN A1026
TYR A1022
ASN A1023
 None
 1.02A 6dwdC-5fv0A:
undetectable		 6dwdC-5fv0A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 5fv0 ESSC
(Geobacillus
thermodenitrific
ans) 		5 / 11 ALA A1434
VAL A1283
THR A1438
ALA A1447
LEU A1445
 None
 1.04A 6h1lB-5fv0A:
undetectable		 6h1lB-5fv0A:
22.73