SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fvn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 5fvn OMPC PORIN
(Enterobacter
cloacae) 		4 / 8 THR A 162
ASN A 164
THR A 167
ASP A 205
 None
 0.91A 1bu5B-5fvnA:
undetectable		 1bu5B-5fvnA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5fvn OMPC PORIN
(Enterobacter
cloacae) 		4 / 6 GLY A 278
GLN A 288
VAL A 243
ALA A 249
 None
 0.99A 1p6kA-5fvnA:
undetectable		 1p6kA-5fvnA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 5fvn OMPC PORIN
(Enterobacter
cloacae) 		4 / 6 ARG A 132
ASP A  89
THR A 130
ASP A  99
 None
 0.96A 2j2pE-5fvnA:
undetectable
2j2pF-5fvnA:
undetectable		 2j2pE-5fvnA:
21.84
2j2pF-5fvnA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5fvn OMPC PORIN
(Enterobacter
cloacae) 		5 / 12 VAL A 334
THR A  34
ASP A  18
VAL A  17
TYR A 309
 None
 1.15A 2y00B-5fvnA:
undetectable		 2y00B-5fvnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5fvn OMPC PORIN
(Enterobacter
cloacae) 		5 / 12 VAL A 334
THR A  34
ASP A  18
VAL A  17
TYR A 309
 None
 1.13A 2y01B-5fvnA:
undetectable		 2y01B-5fvnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 5fvn OMPC PORIN
(Enterobacter
cloacae) 		4 / 4 GLY A  54
TYR A  53
GLY A  79
ASP A  89
 None
 0.68A 3kl3A-5fvnA:
undetectable		 3kl3A-5fvnA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 5fvn OMPC PORIN
(Enterobacter
cloacae) 		4 / 6 ASP A 105
GLY A 111
ASP A 113
THR A 114
 None
C8E  A 407 ( 4.9A)
C8E  A 407 (-3.3A)
None
 0.99A 3vqrA-5fvnA:
undetectable		 3vqrA-5fvnA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 5fvn OMPC PORIN
(Enterobacter
cloacae) 		4 / 6 SER A 155
SER A 202
ASP A 205
GLU A 159
 None
 0.87A 4eysA-5fvnA:
undetectable		 4eysA-5fvnA:
22.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GCP_A_AICA401_1
(OUTER MEMBRANE
PROTEIN F)		 5fvn OMPC PORIN
(Enterobacter
cloacae) 		5 / 9 TYR A  22
PHE A 110
ASP A 113
SER A 117
ARG A 170
 None
C8E  A 407 (-4.6A)
C8E  A 407 (-3.3A)
PO4  A 411 (-2.6A)
PO4  A 411 (-3.1A)
 0.90A 4gcpA-5fvnA:
43.6		 4gcpA-5fvnA:
61.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GCP_A_AICA401_1
(OUTER MEMBRANE
PROTEIN F)		 5fvn OMPC PORIN
(Enterobacter
cloacae) 		5 / 9 TYR A  22
PHE A 110
ASP A 113
SER A 117
ARG A 170
 None
C8E  A 407 (-4.6A)
C8E  A 407 (-3.3A)
PO4  A 411 (-2.6A)
PO4  A 411 (-3.1A)
 1.43A 4gcpA-5fvnA:
43.6		 4gcpA-5fvnA:
61.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GCP_B_AICB401_1
(OUTER MEMBRANE
PROTEIN F)		 5fvn OMPC PORIN
(Enterobacter
cloacae) 		5 / 9 TYR A  22
PHE A 110
ASP A 113
SER A 117
ARG A 170
 None
C8E  A 407 (-4.6A)
C8E  A 407 (-3.3A)
PO4  A 411 (-2.6A)
PO4  A 411 (-3.1A)
 0.88A 4gcpB-5fvnA:
43.6		 4gcpB-5fvnA:
61.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GCP_B_AICB401_1
(OUTER MEMBRANE
PROTEIN F)		 5fvn OMPC PORIN
(Enterobacter
cloacae) 		5 / 9 TYR A  22
PHE A 110
ASP A 113
SER A 117
ARG A 170
 None
C8E  A 407 (-4.6A)
C8E  A 407 (-3.3A)
PO4  A 411 (-2.6A)
PO4  A 411 (-3.1A)
 1.42A 4gcpB-5fvnA:
43.6		 4gcpB-5fvnA:
61.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 5fvn OMPC PORIN
(Enterobacter
cloacae) 		4 / 8 LYS A  16
TYR A  35
ARG A  74
ARG A 124
 None
C8E  A 408 (-4.1A)
None
None
 0.78A 4kr4C-5fvnA:
38.2		 4kr4C-5fvnA:
56.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 5fvn OMPC PORIN
(Enterobacter
cloacae) 		4 / 8 LYS A  16
TYR A  35
ASP A 105
ARG A 124
 None
C8E  A 408 (-4.1A)
None
None
 0.73A 4kr4C-5fvnA:
38.2		 4kr4C-5fvnA:
56.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KR8_C_DM1C401_1
(OUTER MEMBRANE
PROTEIN F)		 5fvn OMPC PORIN
(Enterobacter
cloacae) 		5 / 10 ARG A 124
ARG A  74
TYR A  35
TYR A 115
ARG A  37
 None
None
C8E  A 408 (-4.1A)
None
None
 1.46A 4kr8C-5fvnA:
40.2		 4kr8C-5fvnA:
56.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KR8_C_DM1C401_1
(OUTER MEMBRANE
PROTEIN F)		 5fvn OMPC PORIN
(Enterobacter
cloacae) 		5 / 10 LYS A  16
TYR A  35
ARG A  74
TYR A  94
ARG A 124
 None
C8E  A 408 (-4.1A)
None
None
None
 0.90A 4kr8C-5fvnA:
40.2		 4kr8C-5fvnA:
56.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 5fvn OMPC PORIN
(Enterobacter
cloacae) 		5 / 12 ALA A 193
TYR A 217
SER A 196
SER A 195
GLY A 177
 None
 0.98A 4mmdB-5fvnA:
undetectable		 4mmdB-5fvnA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5fvn OMPC PORIN
(Enterobacter
cloacae) 		4 / 4 SER A 179
ALA A 193
GLN A 122
THR A 101
 None
 1.49A 5n0rA-5fvnA:
undetectable		 5n0rA-5fvnA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5fvn OMPC PORIN
(Enterobacter
cloacae) 		4 / 4 SER A 179
ALA A 193
GLN A 122
THR A 101
 None
 1.48A 5n0sA-5fvnA:
undetectable		 5n0sA-5fvnA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5fvn OMPC PORIN
(Enterobacter
cloacae) 		4 / 4 SER A 179
ALA A 193
GLN A 122
THR A 101
 None
 1.48A 5n0wA-5fvnA:
undetectable		 5n0wA-5fvnA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5fvn OMPC PORIN
(Enterobacter
cloacae) 		5 / 10 GLY A 284
GLU A 282
GLY A 286
VAL A 243
LEU A 246
 None
 1.09A 5o96E-5fvnA:
undetectable
5o96F-5fvnA:
undetectable		 5o96E-5fvnA:
18.75
5o96F-5fvnA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5fvn OMPC PORIN
(Enterobacter
cloacae) 		4 / 7 ASN A 164
ASP A 174
GLY A 175
ASN A 172
 None
L1L  A 414 ( 2.9A)
None
None
 0.82A 5x7pA-5fvnA:
undetectable		 5x7pA-5fvnA:
14.64