SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fwj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens) 		4 / 6 LEU A 716
LEU A 747
LEU A 760
LEU A 763
 None
 0.93A 1errA-5fwjA:
undetectable		 1errA-5fwjA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens) 		4 / 8 GLY A 604
THR A 533
GLY A 608
GLN A 607
 None
 0.70A 1jr1B-5fwjA:
undetectable		 1jr1B-5fwjA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_C_DMEC997_1
(ACETYLCHOLINESTERASE)		 5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens) 		5 / 12 GLY A 591
PHE A 593
PHE A 453
TYR A 469
HIS A 527
 None
 1.34A 1maaC-5fwjA:
undetectable		 1maaC-5fwjA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)		 5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens) 		4 / 6 ASN A 475
TRP A  52
TYR A 525
GLY A 452
 None
 1.43A 1mxdA-5fwjA:
undetectable		 1mxdA-5fwjA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens) 		3 / 3 TRP A  21
PHE A  24
TRP A  52
 None
 1.41A 1r15C-5fwjA:
undetectable		 1r15C-5fwjA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens) 		3 / 3 TRP A  21
PHE A  24
TRP A  52
 None
 1.41A 1r15F-5fwjA:
undetectable		 1r15F-5fwjA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens) 		3 / 3 TRP A  21
PHE A  24
TRP A  52
 None
 1.42A 1r15G-5fwjA:
undetectable		 1r15G-5fwjA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens) 		3 / 3 TRP A  21
PHE A  24
TRP A  52
 None
 1.42A 1r15H-5fwjA:
undetectable		 1r15H-5fwjA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens) 		5 / 10 ALA A 612
TRP A 534
LEU A 526
GLY A 591
PHE A 593
 None
 1.35A 1ruaH-5fwjA:
undetectable
1ruaL-5fwjA:
undetectable		 1ruaH-5fwjA:
15.48
1ruaL-5fwjA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens) 		4 / 7 VAL A 666
VAL A 674
TYR A 749
ARG A 766
 None
 1.28A 1t46A-5fwjA:
undetectable		 1t46A-5fwjA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens) 		4 / 6 VAL A 486
LEU A 487
PHE A 642
MET A 497
 None
 1.10A 1x8vA-5fwjA:
undetectable		 1x8vA-5fwjA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens) 		5 / 12 ILE A 515
LEU A 576
VAL A 537
GLU A 546
LEU A 545
 None
 1.21A 2bxfA-5fwjA:
undetectable		 2bxfA-5fwjA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens) 		5 / 12 ILE A 515
LEU A 576
VAL A 537
GLU A 546
LEU A 545
 None
 1.21A 2bxfB-5fwjA:
undetectable		 2bxfB-5fwjA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens) 		4 / 6 MET A 479
ILE A  31
PRO A 500
SER A 451
 None
 1.37A 2qd3B-5fwjA:
undetectable		 2qd3B-5fwjA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens) 		5 / 12 SER A 472
HIS A 527
PRO A  55
LEU A 462
SER A 451
 None
 1.48A 2xrlA-5fwjA:
undetectable		 2xrlA-5fwjA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens) 		4 / 8 ALA A 600
TRP A 513
GLY A  42
ILE A  43
 None
 0.68A 2zm9A-5fwjA:
undetectable		 2zm9A-5fwjA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens) 		3 / 3 PHE A  17
CYH A  44
PHE A 597
 None
 0.99A 3cr5X-5fwjA:
undetectable		 3cr5X-5fwjA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens) 		5 / 12 GLY A 441
TYR A 392
VAL A 504
GLY A 505
MET A 506
 None
 1.37A 3f8wB-5fwjA:
undetectable		 3f8wB-5fwjA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_A_P77A203_1
(PROTEIN S100-A4)		 5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens) 		5 / 10 SER A 732
GLU A 677
LEU A 756
SER A 717
CYH A 649
 None
 1.45A 3m0wA-5fwjA:
undetectable
3m0wB-5fwjA:
undetectable
3m0wI-5fwjA:
undetectable
3m0wJ-5fwjA:
undetectable		 3m0wA-5fwjA:
14.63
3m0wB-5fwjA:
14.63
3m0wI-5fwjA:
14.63
3m0wJ-5fwjA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens) 		4 / 7 ILE A  69
LYS A 405
PHE A 397
GLY A 505
 None
 1.19A 3sj0X-5fwjA:
undetectable		 3sj0X-5fwjA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens) 		4 / 7 PRO A  36
LYS A  40
GLY A  42
PRO A 538
 None
 1.07A 3ucbB-5fwjA:
undetectable		 3ucbB-5fwjA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens) 		4 / 5 PHE A 597
ARG A  35
PRO A  36
ALA A  38
 None
 1.11A 3vm4A-5fwjA:
undetectable		 3vm4A-5fwjA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens) 		4 / 7 ILE A  69
THR A 389
VAL A 436
ASP A 407
 None
 1.20A 4iarA-5fwjA:
undetectable		 4iarA-5fwjA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_E_SPME202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens) 		4 / 5 GLU A 467
GLU A 468
TYR A 469
GLU A 466
 None
 1.36A 4r87E-5fwjA:
undetectable		 4r87E-5fwjA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens) 		4 / 7 GLU A 467
GLU A 468
TYR A 469
GLU A 466
 None
 1.21A 4r87I-5fwjA:
undetectable		 4r87I-5fwjA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens) 		4 / 6 TYR A 469
TYR A 525
LEU A 476
PHE A 593
 None
 1.20A 4twdB-5fwjA:
3.2
4twdC-5fwjA:
3.1		 4twdB-5fwjA:
20.09
4twdC-5fwjA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens) 		4 / 6 TYR A 469
TYR A 525
LEU A 476
PHE A 593
 None
 1.13A 4twdD-5fwjA:
2.9
4twdE-5fwjA:
3.1		 4twdD-5fwjA:
20.09
4twdE-5fwjA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens) 		4 / 7 TYR A 525
LEU A 476
PHE A 593
TYR A 469
 None
 1.16A 4twdF-5fwjA:
undetectable
4twdJ-5fwjA:
undetectable		 4twdF-5fwjA:
20.09
4twdJ-5fwjA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens) 		4 / 6 TYR A 469
TYR A 525
LEU A 476
PHE A 593
 None
 1.16A 4twdF-5fwjA:
undetectable
4twdG-5fwjA:
1.2		 4twdF-5fwjA:
20.09
4twdG-5fwjA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens) 		4 / 6 TYR A 469
TYR A 525
LEU A 476
PHE A 593
 None
 1.16A 4twdI-5fwjA:
undetectable
4twdJ-5fwjA:
undetectable		 4twdI-5fwjA:
20.09
4twdJ-5fwjA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens) 		4 / 8 TYR A 601
GLY A  42
ILE A  43
PRO A 573
 None
 0.91A 6ag0A-5fwjA:
undetectable		 6ag0A-5fwjA:
9.64