SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fwm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 5fwm HEAT SHOCK PROTEIN
HSP 90 BETA
(Homo
sapiens) 		4 / 8 ASN A 150
THR A 179
ASP A  74
GLY A  92
 None
ATP  A1691 (-4.4A)
None
ATP  A1691 ( 4.4A)
 0.98A 1bu5B-5fwmA:
undetectable		 1bu5B-5fwmA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 5fwm HEAT SHOCK PROTEIN
HSP 90 BETA
(Homo
sapiens) 		5 / 12 LEU A 282
LEU A 215
ASN A 283
THR A  89
LEU A  51
 None
 1.05A 1og5A-5fwmA:
undetectable		 1og5A-5fwmA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5fwm HEAT SHOCK PROTEIN
HSP 90 BETA
(Homo
sapiens) 		4 / 7 ILE A 377
PRO A 336
PHE A 433
ASN A 436
 None
 0.99A 1oniG-5fwmA:
undetectable
1oniI-5fwmA:
undetectable		 1oniG-5fwmA:
11.77
1oniI-5fwmA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5fwm HEAT SHOCK PROTEIN
HSP 90 BETA
(Homo
sapiens) 		5 / 12 LEU A 563
CYH A 564
LEU A 566
VAL A 651
ILE A 580
 None
 1.06A 1s9pC-5fwmA:
undetectable		 1s9pC-5fwmA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 5fwm HEAT SHOCK PROTEIN
HSP 90 BETA
(Homo
sapiens) 		4 / 6 LEU A 657
LEU A 654
ILE A 680
ARG A 682
 None
 0.88A 2rlfB-5fwmA:
undetectable
2rlfC-5fwmA:
undetectable		 2rlfB-5fwmA:
6.35
2rlfC-5fwmA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5fwm HEAT SHOCK PROTEIN
HSP 90 BETA
(Homo
sapiens) 		4 / 5 LEU A  98
GLN A 154
THR A 147
THR A 166
 None
 1.39A 2zj0C-5fwmA:
undetectable		 2zj0C-5fwmA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5fwm HEAT SHOCK PROTEIN
HSP 90 BETA
(Homo
sapiens) 		4 / 4 LEU A  98
GLN A 154
THR A 147
THR A 166
 None
 1.46A 2zj0D-5fwmA:
undetectable		 2zj0D-5fwmA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_2
(ADENOSYLHOMOCYSTEINA
SE)		 5fwm HEAT SHOCK PROTEIN
HSP 90 BETA
(Homo
sapiens) 		4 / 5 GLN A 154
THR A 147
THR A 166
HIS A 171
 None
 1.43A 3g1uC-5fwmA:
undetectable		 3g1uC-5fwmA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_B_P77B204_1
(PROTEIN S100-A4)		 5fwm HEAT SHOCK PROTEIN
HSP 90 BETA
(Homo
sapiens) 		4 / 6 CYH A 589
GLU A 627
PHE A 499
PHE A 668
 None
 1.45A 3m0wB-5fwmA:
undetectable
3m0wJ-5fwmA:
undetectable		 3m0wB-5fwmA:
8.84
3m0wJ-5fwmA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_C_P77C203_1
(PROTEIN S100-A4)		 5fwm HEAT SHOCK PROTEIN
HSP 90 BETA
(Homo
sapiens) 		5 / 10 ASP A  49
SER A  48
PHE A 361
ILE A 362
LEU A 388
 None
 1.35A 3m0wC-5fwmA:
undetectable
3m0wD-5fwmA:
undetectable
3m0wE-5fwmA:
undetectable
3m0wF-5fwmA:
undetectable		 3m0wC-5fwmA:
8.84
3m0wD-5fwmA:
8.84
3m0wE-5fwmA:
8.84
3m0wF-5fwmA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 5fwm HEAT SHOCK PROTEIN
HSP 90 BETA
(Homo
sapiens) 		5 / 12 GLY A 132
ASN A  46
ILE A  28
GLY A 130
PHE A 129
 ATP  A1691 (-3.7A)
MG  A1692 ( 1.9A)
None
ATP  A1691 (-3.2A)
ATP  A1691 (-4.2A)
 1.23A 3ps9A-5fwmA:
undetectable		 3ps9A-5fwmA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5fwm HEAT SHOCK PROTEIN
HSP 90 BETA
(Homo
sapiens) 		4 / 7 ILE A 441
TYR A 457
HIS A 458
VAL A 494
 None
 1.09A 4a97D-5fwmA:
2.0		 4a97D-5fwmA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5fwm HEAT SHOCK PROTEIN
HSP 90 BETA
(Homo
sapiens) 		4 / 7 ILE A 441
TYR A 457
HIS A 458
VAL A 494
 None
 1.10A 4a97H-5fwmA:
undetectable		 4a97H-5fwmA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5fwm HEAT SHOCK PROTEIN
HSP 90 BETA
(Homo
sapiens) 		4 / 6 ILE A 441
TYR A 457
HIS A 458
VAL A 494
 None
 1.15A 4a97I-5fwmA:
undetectable		 4a97I-5fwmA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5fwm HEAT SHOCK PROTEIN
HSP 90 BETA
(Homo
sapiens) 		5 / 12 ILE A 123
VAL A 360
ASP A  49
ILE A 126
GLU A  42
 None
None
None
None
ATP  A1691 (-4.0A)
 1.38A 4i41A-5fwmA:
undetectable		 4i41A-5fwmA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 5fwm HEAT SHOCK PROTEIN
HSP 90 BETA
(Homo
sapiens) 		5 / 10 LEU A 343
ALA A 317
PHE A 429
PHE A 416
LEU A 374
 None
 1.45A 4la0A-5fwmA:
undetectable		 4la0A-5fwmA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_B_198B601_1
(SERUM ALBUMIN)		 5fwm HEAT SHOCK PROTEIN
HSP 90 BETA
(Homo
sapiens) 		5 / 9 LEU A 343
ALA A 317
PHE A 429
PHE A 416
LEU A 374
 None
 1.41A 4la0B-5fwmA:
2.3		 4la0B-5fwmA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 5fwm HEAT SHOCK PROTEIN
HSP 90 BETA
(Homo
sapiens) 		5 / 12 ILE A 182
ILE A  75
THR A 179
VAL A 202
ILE A 213
 None
None
ATP  A1691 (-4.4A)
None
None
 0.99A 4q5mA-5fwmA:
undetectable		 4q5mA-5fwmA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 5fwm HEAT SHOCK PROTEIN
HSP 90 BETA
(Homo
sapiens) 		5 / 12 LEU A 663
ALA A 662
LEU A 658
LEU A 626
LEU A 584
 None
 1.06A 4xi3C-5fwmA:
undetectable		 4xi3C-5fwmA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 5fwm HEAT SHOCK PROTEIN
HSP 90 BETA
(Homo
sapiens) 		5 / 12 LEU A 183
ALA A 136
SER A 135
GLY A 103
LEU A 102
 None
None
None
None
ATP  A1691 ( 4.9A)
 1.19A 5m5cB-5fwmA:
undetectable		 5m5cB-5fwmA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 5fwm HEAT SHOCK PROTEIN
HSP 90 BETA
(Homo
sapiens) 		5 / 12 LEU A 183
ALA A 136
THR A 179
GLY A 103
LEU A 102
 None
None
ATP  A1691 (-4.4A)
None
ATP  A1691 ( 4.9A)
 1.16A 5m5cB-5fwmA:
undetectable		 5m5cB-5fwmA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5fwm HEAT SHOCK PROTEIN
HSP 90 BETA
(Homo
sapiens) 		5 / 10 LEU A 183
ALA A 136
SER A 135
GLY A 103
LEU A 102
 None
None
None
None
ATP  A1691 ( 4.9A)
 1.19A 5m5cE-5fwmA:
undetectable		 5m5cE-5fwmA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5fwm HEAT SHOCK PROTEIN
HSP 90 BETA
(Homo
sapiens) 		5 / 10 LEU A 183
ALA A 136
THR A 179
GLY A 103
LEU A 102
 None
None
ATP  A1691 (-4.4A)
None
ATP  A1691 ( 4.9A)
 1.16A 5m5cE-5fwmA:
undetectable		 5m5cE-5fwmA:
19.51