SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fws'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 5fws KREMEN PROTEIN 1
(Homo
sapiens) 		4 / 8 ASP A  88
ASP A  90
TRP A  94
TYR A  96
 None
 0.52A 1ceaA-5fwsA:
undetectable
1ceaB-5fwsA:
undetectable		 1ceaA-5fwsA:
11.39
1ceaB-5fwsA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 5fws KREMEN PROTEIN 1
(Homo
sapiens) 		4 / 7 ASP A  88
ASP A  90
TRP A  94
TYR A  96
 None
 0.54A 1ceaB-5fwsA:
undetectable		 1ceaB-5fwsA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 5fws KREMEN PROTEIN 1
(Homo
sapiens) 		4 / 7 ASP A  88
ASP A  90
TRP A  94
TYR A  96
 None
 0.64A 1cebA-5fwsA:
10.2		 1cebA-5fwsA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_B_AMHB90_1
(PLASMINOGEN)		 5fws KREMEN PROTEIN 1
(Homo
sapiens) 		4 / 7 ASP A  88
ASP A  90
TRP A  94
TYR A  96
 None
 0.57A 1cebB-5fwsA:
10.2		 1cebB-5fwsA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 5fws KREMEN PROTEIN 1
(Homo
sapiens) 		4 / 8 ASP A  88
ASP A  90
TRP A  94
TRP A 106
 None
 0.89A 1pk2A-5fwsA:
8.2		 1pk2A-5fwsA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 5fws KREMEN PROTEIN 1
(Homo
sapiens) 		4 / 8 TYR A  66
ASP A  88
ASP A  90
TRP A  94
 None
 0.83A 1pk2A-5fwsA:
8.2		 1pk2A-5fwsA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PK4_A_ACAA100_1
(HUMAN PLASMINOGEN
KRINGLE 4)		 5fws KREMEN PROTEIN 1
(Homo
sapiens) 		4 / 7 ASP A  88
ASP A  90
TRP A  94
TRP A 106
 None
 0.47A 2pk4A-5fwsA:
10.1		 2pk4A-5fwsA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KIV_A_ACAA100_1
(APOLIPOPROTEIN)		 5fws KREMEN PROTEIN 1
(Homo
sapiens) 		4 / 7 ASP A  88
ASP A  90
TRP A  94
TRP A 106
 None
 0.21A 3kivA-5fwsA:
10.3		 3kivA-5fwsA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 5fws KREMEN PROTEIN 1
(Homo
sapiens) 		4 / 8 PHE A 168
THR A 133
PRO A 131
GLY A 127
 None
 1.04A 3tzfB-5fwsA:
undetectable		 3tzfB-5fwsA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 5fws KREMEN PROTEIN 1
(Homo
sapiens) 		4 / 8 SER A 291
ALA A 315
LEU A 317
SER A 255
 NAG  A1326 ( 4.4A)
None
None
None
 0.78A 4iklA-5fwsA:
undetectable
4iklB-5fwsA:
undetectable		 4iklA-5fwsA:
13.17
4iklB-5fwsA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5fws KREMEN PROTEIN 1
(Homo
sapiens) 		4 / 7 SER A  92
ASN A 187
ASN A  86
TRP A 106
 None
 1.41A 4kcnB-5fwsA:
undetectable		 4kcnB-5fwsA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5fws KREMEN PROTEIN 1
(Homo
sapiens) 		4 / 4 LEU A 296
ILE A 252
GLY A 273
ILE A 244
 None
 0.83A 5dzk3-5fwsA:
undetectable
5dzkm-5fwsA:
undetectable		 5dzk3-5fwsA:
15.38
5dzkm-5fwsA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5fws KREMEN PROTEIN 1
(Homo
sapiens) 		4 / 5 ILE A 252
GLY A 273
ILE A 244
LEU A 296
 None
 0.86A 5dzki-5fwsA:
undetectable
5dzkj-5fwsA:
undetectable
5dzkx-5fwsA:
undetectable		 5dzki-5fwsA:
19.36
5dzkj-5fwsA:
19.36
5dzkx-5fwsA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fws KREMEN PROTEIN 1
(Homo
sapiens) 		3 / 3 GLY A  42
THR A 195
PRO A  93
 None
 0.60A 5v5zA-5fwsA:
undetectable		 5v5zA-5fwsA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 5fws KREMEN PROTEIN 1
(Homo
sapiens) 		3 / 3 ASP A 306
ASP A 260
ASN A  36
 CA  A1327 (-2.8A)
None
None
 0.55A 6gngB-5fwsA:
undetectable		 6gngB-5fwsA:
21.38