SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fww'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 5fww KREMEN PROTEIN 1
(Homo
sapiens) 		4 / 8 ASP B  88
ASP B  90
TRP B  94
TYR B  96
 None
 0.69A 1ceaA-5fwwB:
undetectable
1ceaB-5fwwB:
undetectable		 1ceaA-5fwwB:
19.20
1ceaB-5fwwB:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 5fww KREMEN PROTEIN 1
(Homo
sapiens) 		4 / 7 ASP B  88
ASP B  90
TRP B  94
TYR B  96
 None
 0.66A 1ceaB-5fwwB:
undetectable		 1ceaB-5fwwB:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 5fww KREMEN PROTEIN 1
(Homo
sapiens) 		4 / 7 ASP B  88
ASP B  90
TRP B  94
TYR B  96
 None
 0.65A 1cebA-5fwwB:
9.8		 1cebA-5fwwB:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_B_AMHB90_1
(PLASMINOGEN)		 5fww KREMEN PROTEIN 1
(Homo
sapiens) 		4 / 7 ASP B  88
ASP B  90
TRP B  94
TYR B  96
 None
 0.76A 1cebB-5fwwB:
9.9		 1cebB-5fwwB:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5fww KREMEN PROTEIN 1
(Homo
sapiens) 		4 / 6 ASN B 119
ILE B 111
SER B  92
ASN B 187
 None
 1.18A 1h7xA-5fwwB:
undetectable		 1h7xA-5fwwB:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5fww KREMEN PROTEIN 1
(Homo
sapiens) 		4 / 6 ASN B 119
ILE B 111
SER B  92
ASN B 187
 None
 1.18A 1h7xB-5fwwB:
undetectable		 1h7xB-5fwwB:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5fww KREMEN PROTEIN 1
(Homo
sapiens) 		4 / 6 ASN B 119
ILE B 111
SER B  92
ASN B 187
 None
 1.18A 1h7xC-5fwwB:
undetectable		 1h7xC-5fwwB:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5fww KREMEN PROTEIN 1
(Homo
sapiens) 		4 / 6 ASN B 119
ILE B 111
SER B  92
ASN B 187
 None
 1.18A 1h7xD-5fwwB:
undetectable		 1h7xD-5fwwB:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 5fww KREMEN PROTEIN 1
(Homo
sapiens) 		4 / 8 TYR B  66
ASP B  88
ASP B  90
TRP B  94
 None
 0.98A 1pk2A-5fwwB:
7.6		 1pk2A-5fwwB:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		 5fww KREMEN PROTEIN 1
(Homo
sapiens) 		6 / 12 GLY B 160
ALA B 159
ASP B 208
VAL B 211
PRO B 231
ILE B 148
 None
 1.41A 2avoB-5fwwB:
undetectable		 2avoB-5fwwB:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5fww KREMEN PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU B 258
ASP B  39
GLY B  37
SER B  92
ASN B  36
 None
 1.34A 2ycjA-5fwwB:
undetectable		 2ycjA-5fwwB:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 5fww KREMEN PROTEIN 1
DICKKOPF-RELATED
PROTEIN 1
(Homo
sapiens;
Homo
sapiens) 		3 / 3 GLU B 185
ASP B 201
TYR C 238
 None
 0.87A 2yvlB-5fwwB:
undetectable		 2yvlB-5fwwB:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 5fww KREMEN PROTEIN 1
(Homo
sapiens) 		5 / 12 PHE B 207
LEU B 301
GLY B 212
ILE B 144
ASP B 193
 None
 1.25A 2zznB-5fwwB:
undetectable		 2zznB-5fwwB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 5fww KREMEN PROTEIN 1
DICKKOPF-RELATED
PROTEIN 1
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR B 165
LEU C 190
LYS C 208
SER C 193
 None
 1.39A 3lslA-5fwwB:
undetectable
3lslD-5fwwB:
undetectable		 3lslA-5fwwB:
22.78
3lslD-5fwwB:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 5fww KREMEN PROTEIN 1
DICKKOPF-RELATED
PROTEIN 1
(Homo
sapiens;
Homo
sapiens) 		4 / 7 SER C 193
TYR B 165
LEU C 190
LYS C 208
 None
 1.32A 3lslA-5fwwC:
undetectable
3lslD-5fwwC:
undetectable		 3lslA-5fwwC:
13.95
3lslD-5fwwC:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 5fww KREMEN PROTEIN 1
(Homo
sapiens) 		4 / 8 PHE B 168
THR B 133
PRO B 131
GLY B 127
 None
 1.02A 3tzfB-5fwwB:
undetectable		 3tzfB-5fwwB:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 5fww KREMEN PROTEIN 1
(Homo
sapiens) 		4 / 8 SER B 291
ALA B 315
LEU B 317
SER B 255
 None
 0.68A 4iklA-5fwwB:
undetectable
4iklB-5fwwB:
undetectable		 4iklA-5fwwB:
18.09
4iklB-5fwwB:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5fww DICKKOPF-RELATED
PROTEIN 1
KREMEN PROTEIN 1
(Homo
sapiens) 		4 / 7 ASP B 201
SER C 192
ALA C 202
ARG C 203
 None
 1.25A 4lv9A-5fwwB:
undetectable
4lv9B-5fwwB:
undetectable		 4lv9A-5fwwB:
20.77
4lv9B-5fwwB:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5fww KREMEN PROTEIN 1
(Homo
sapiens) 		4 / 4 LEU B 296
ILE B 252
GLY B 273
ILE B 244
 None
 0.86A 5dzk3-5fwwB:
undetectable
5dzkm-5fwwB:
undetectable		 5dzk3-5fwwB:
0.83
5dzkm-5fwwB:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5fww KREMEN PROTEIN 1
(Homo
sapiens) 		3 / 3 GLY B  42
THR B 195
PRO B  93
 None
 0.65A 5v5zA-5fwwB:
undetectable		 5v5zA-5fwwB:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 5fww KREMEN PROTEIN 1
(Homo
sapiens) 		3 / 3 ASP B 306
ASP B 260
ASN B  36
 CA  B1323 (-3.5A)
None
None
 0.75A 6gngB-5fwwB:
undetectable		 6gngB-5fwwB:
17.51