SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fwx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 5fwx GLUTAMATE RECEPTOR 4
(Rattus
norvegicus) 		5 / 12 ILE B 204
ALA B 236
LEU B 358
ILE B 226
LEU B 197
 None
 1.07A 1drfA-5fwxB:
undetectable		 1drfA-5fwxB:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 5fwx GLUTAMATE RECEPTOR 4
(Rattus
norvegicus) 		4 / 8 LEU B 124
VAL B 366
GLY B 367
TYR B 128
 None
 1.01A 1jlfA-5fwxB:
undetectable
1jlfB-5fwxB:
undetectable		 1jlfA-5fwxB:
22.20
1jlfB-5fwxB:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5fwx GLUTAMATE RECEPTOR 4
(Rattus
norvegicus) 		4 / 7 LEU B 124
VAL B 366
GLY B 367
TYR B 128
 None
 0.97A 1lweA-5fwxB:
undetectable		 1lweA-5fwxB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 5fwx GLUTAMATE RECEPTOR 4
(Rattus
norvegicus) 		4 / 8 LEU B 124
VAL B 366
GLY B 367
TYR B 128
 None
 1.02A 1s1xA-5fwxB:
undetectable		 1s1xA-5fwxB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 5fwx GLUTAMATE RECEPTOR 4
(Rattus
norvegicus) 		3 / 3 ASP B 191
TYR B 137
GLU B 166
 None
 0.85A 1vm1A-5fwxB:
undetectable		 1vm1A-5fwxB:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 5fwx GLUTAMATE RECEPTOR 4
(Rattus
norvegicus) 		5 / 12 ILE B 204
ALA B 236
LEU B 358
ILE B 226
LEU B 197
 None
 1.11A 2w3bA-5fwxB:
undetectable		 2w3bA-5fwxB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 5fwx GLUTAMATE RECEPTOR 4
(Rattus
norvegicus) 		6 / 12 ILE B 204
ALA B 236
LEU B 358
ILE B 226
ASN B 220
LEU B 197
 None
 1.44A 2w3bB-5fwxB:
2.3		 2w3bB-5fwxB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 5fwx GLUTAMATE RECEPTOR 4
(Rattus
norvegicus) 		4 / 8 GLY B 335
PHE B  12
GLY B 283
PHE B  74
 None
 0.97A 3ko0O-5fwxB:
undetectable
3ko0Q-5fwxB:
undetectable		 3ko0O-5fwxB:
12.79
3ko0Q-5fwxB:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5fwx GLUTAMATE RECEPTOR 4
(Rattus
norvegicus) 		4 / 4 GLY B 268
GLU B 270
ASP B 262
ASP B  17
 None
 1.18A 3mb5A-5fwxB:
5.0		 3mb5A-5fwxB:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 5fwx GLUTAMATE RECEPTOR 4
(Rattus
norvegicus) 		4 / 5 LEU B 375
ILE B 217
ALA B 120
PHE B 241
 None
 0.98A 4dc3B-5fwxB:
2.4		 4dc3B-5fwxB:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 5fwx GLUTAMATE RECEPTOR 4
(Rattus
norvegicus) 		6 / 12 ILE B 204
ALA B 236
LEU B 358
ILE B 226
ASN B 220
LEU B 197
 None
 1.50A 4kebB-5fwxB:
undetectable		 4kebB-5fwxB:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5fwx GLUTAMATE RECEPTOR 4
(Rattus
norvegicus) 		5 / 12 ILE B 204
ALA B 236
LEU B 358
ILE B 226
LEU B 197
 None
 1.08A 4m6kA-5fwxB:
2.3		 4m6kA-5fwxB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 5fwx GLUTAMATE RECEPTOR 4
(Rattus
norvegicus) 		4 / 5 ASP B 245
ASP B 225
PHE B 356
GLY B 222
 None
 1.08A 4xp6A-5fwxB:
undetectable		 4xp6A-5fwxB:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5fwx GLUTAMATE RECEPTOR 4
(Rattus
norvegicus) 		4 / 4 SER B 277
ALA B 278
GLN B 242
THR B 337
 None
 1.39A 5n0rA-5fwxB:
1.6		 5n0rA-5fwxB:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5fwx GLUTAMATE RECEPTOR 4
(Rattus
norvegicus) 		4 / 4 SER B 277
ALA B 278
GLN B 242
THR B 337
 None
 1.38A 5n0sA-5fwxB:
undetectable		 5n0sA-5fwxB:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5fwx GLUTAMATE RECEPTOR 4
(Rattus
norvegicus) 		4 / 5 SER B 277
ALA B 278
GLN B 242
THR B 337
 None
 1.39A 5n0tA-5fwxB:
3.8		 5n0tA-5fwxB:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5fwx GLUTAMATE RECEPTOR 4
(Rattus
norvegicus) 		4 / 4 SER B 277
ALA B 278
GLN B 242
THR B 337
 None
 1.38A 5n0wA-5fwxB:
3.7		 5n0wA-5fwxB:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5fwx GLUTAMATE RECEPTOR 4
(Rattus
norvegicus) 		4 / 5 SER B 277
ALA B 278
GLN B 242
THR B 337
 None
 1.38A 5n0wB-5fwxB:
3.7		 5n0wB-5fwxB:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5fwx GLUTAMATE RECEPTOR 4
(Rattus
norvegicus) 		4 / 4 SER B 277
ALA B 278
GLN B 242
THR B 337
 None
 1.37A 5n0xA-5fwxB:
undetectable		 5n0xA-5fwxB:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5fwx GLUTAMATE RECEPTOR 4
(Rattus
norvegicus) 		4 / 5 SER B 277
ALA B 278
GLN B 242
THR B 337
 None
 1.37A 5n4iA-5fwxB:
3.4		 5n4iA-5fwxB:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 5fwx GLUTAMATE RECEPTOR 4
(Rattus
norvegicus) 		5 / 12 PHE B  12
GLY B  75
GLY B  10
ILE B   8
LEU B 285
 None
 1.06A 5ul4A-5fwxB:
7.4		 5ul4A-5fwxB:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		 5fwx GLUTAMATE RECEPTOR 4
(Rattus
norvegicus) 		5 / 9 ASP B  48
GLY B  10
GLY B   9
ALA B  72
VAL B  70
 None
 1.29A 5v3cA-5fwxB:
undetectable		 5v3cA-5fwxB:
12.53