SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fx8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CIL_A_ETSA263_1
(CARBONIC ANHYDRASE
II)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		5 / 12 GLN A 287
HIS A 290
HIS A 294
PHE A 347
LEU A 336
 None
MN  A1000 (-3.5A)
MN  A1000 (-3.3A)
None
None
 1.14A 1cilA-5fx8A:
undetectable		 1cilA-5fx8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		4 / 5 HIS A 141
GLU A 117
ALA A 111
SER A 534
 None
None
None
NAG  A1009 ( 4.9A)
 1.34A 1errA-5fx8A:
undetectable
1errB-5fx8A:
undetectable		 1errA-5fx8A:
18.15
1errB-5fx8A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 5fx8 ZONADHESIN
(Komagataella
phaffii) 		3 / 3 ASP U  25
PHE U 150
VAL U  28
 None
 0.79A 1kijB-5fx8U:
undetectable		 1kijB-5fx8U:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_1
(CARBONIC ANHYDRASE
II)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		5 / 12 GLN A 287
HIS A 290
HIS A 294
PHE A 347
LEU A 336
 None
MN  A1000 (-3.5A)
MN  A1000 (-3.3A)
None
None
 1.16A 1oq5A-5fx8A:
undetectable		 1oq5A-5fx8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKY_A_CUA801_0
(LYSYL OXIDASE)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		3 / 3 HIS A 294
HIS A 290
HIS A 478
 MN  A1000 (-3.3A)
MN  A1000 (-3.5A)
MN  A1000 (-3.4A)
 0.67A 1rkyA-5fx8A:
undetectable		 1rkyA-5fx8A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1URM_A_BEZA201_0
(PEROXIREDOXIN 5)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		5 / 9 PRO A 358
GLY A 359
SER A 360
LEU A 349
PHE A 284
 None
 1.47A 1urmA-5fx8A:
undetectable		 1urmA-5fx8A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_B_CUB701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		3 / 3 HIS A 294
HIS A 290
HIS A 478
 MN  A1000 (-3.3A)
MN  A1000 (-3.5A)
MN  A1000 (-3.4A)
 0.71A 1w2zB-5fx8A:
undetectable		 1w2zB-5fx8A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		4 / 5 TYR A  83
TYR A 326
ILE A  92
GLY A  73
 None
 1.17A 2du8J-5fx8A:
undetectable		 2du8J-5fx8A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		4 / 6 ARG A 541
GLN A 483
ASN A 482
LEU A 404
 None
None
MN  A1000 (-3.3A)
None
 1.28A 2nyrA-5fx8A:
undetectable		 2nyrA-5fx8A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2POU_A_I7AA1000_1
(CARBONIC ANHYDRASE 2)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		5 / 12 GLN A 287
HIS A 290
HIS A 294
PHE A 347
LEU A 336
 None
MN  A1000 (-3.5A)
MN  A1000 (-3.3A)
None
None
 1.16A 2pouA-5fx8A:
undetectable		 2pouA-5fx8A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		4 / 7 PRO A 609
LEU A 404
ALA A 407
PHE A 575
 None
 0.99A 2vcvL-5fx8A:
1.2		 2vcvL-5fx8A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_A_CUA801_0
(COPPER AMINE OXIDASE)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		3 / 3 HIS A 294
HIS A 290
HIS A 478
 MN  A1000 (-3.3A)
MN  A1000 (-3.5A)
MN  A1000 (-3.4A)
 0.70A 2w0qA-5fx8A:
undetectable		 2w0qA-5fx8A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_B_CUB801_0
(COPPER AMINE OXIDASE)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		3 / 3 HIS A 294
HIS A 290
HIS A 478
 MN  A1000 (-3.3A)
MN  A1000 (-3.5A)
MN  A1000 (-3.4A)
 0.71A 2w0qB-5fx8A:
undetectable		 2w0qB-5fx8A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		5 / 10 ALA A 304
LEU A 318
ILE A 440
PHE A 452
THR A 307
 None
 1.22A 2w9sF-5fx8A:
undetectable		 2w9sF-5fx8A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		4 / 6 GLY A 509
ALA A 507
LEU A 273
PRO A 505
 None
 0.96A 3bgdA-5fx8A:
undetectable		 3bgdA-5fx8A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		4 / 6 PHE A 188
GLN A 235
LEU A 179
LEU A 214
 None
 0.49A 3bgdA-5fx8A:
undetectable		 3bgdA-5fx8A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		4 / 7 PHE A 188
GLN A 235
LEU A 237
LEU A 179
 None
 0.66A 3bgdB-5fx8A:
undetectable		 3bgdB-5fx8A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		4 / 7 PHE A 188
LEU A 237
LEU A 179
LEU A 214
 None
 0.51A 3bgdB-5fx8A:
undetectable		 3bgdB-5fx8A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BL1_A_BL1A300_1
(CARBONIC ANHYDRASE 2)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		5 / 12 GLN A 287
HIS A 290
HIS A 294
PHE A 347
LEU A 336
 None
MN  A1000 (-3.5A)
MN  A1000 (-3.3A)
None
None
 1.18A 3bl1A-5fx8A:
undetectable		 3bl1A-5fx8A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZV_A_AZMA263_1
(CARBONIC ANHYDRASE
13)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		5 / 12 GLN A 287
HIS A 290
HIS A 294
PHE A 347
LEU A 336
 None
MN  A1000 (-3.5A)
MN  A1000 (-3.3A)
None
None
 1.14A 3czvA-5fx8A:
undetectable
3czvB-5fx8A:
undetectable		 3czvA-5fx8A:
16.67
3czvB-5fx8A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		5 / 10 GLN A 287
HIS A 290
HIS A 294
PHE A 347
LEU A 336
 None
MN  A1000 (-3.5A)
MN  A1000 (-3.3A)
None
None
 1.15A 3dazA-5fx8A:
undetectable		 3dazA-5fx8A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		5 / 10 GLN A 287
HIS A 290
HIS A 294
PHE A 347
LEU A 336
 None
MN  A1000 (-3.5A)
MN  A1000 (-3.3A)
None
None
 1.12A 3dcsA-5fx8A:
undetectable		 3dcsA-5fx8A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		4 / 8 GLY A 359
ASP A 356
ILE A 355
VAL A 291
 None
 0.81A 3fi0B-5fx8A:
undetectable		 3fi0B-5fx8A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_CUB801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		3 / 3 HIS A 294
HIS A 290
HIS A 478
 MN  A1000 (-3.3A)
MN  A1000 (-3.5A)
MN  A1000 (-3.4A)
 0.72A 3hiiB-5fx8A:
undetectable		 3hiiB-5fx8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		5 / 12 GLN A 287
HIS A 290
HIS A 294
PHE A 347
LEU A 336
 None
MN  A1000 (-3.5A)
MN  A1000 (-3.3A)
None
None
 1.13A 3hkuA-5fx8A:
undetectable		 3hkuA-5fx8A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA701_1
(CARBONIC ANHYDRASE 2)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		5 / 11 GLN A 287
HIS A 290
HIS A 294
PHE A 347
LEU A 336
 None
MN  A1000 (-3.5A)
MN  A1000 (-3.3A)
None
None
 1.18A 3hs4A-5fx8A:
undetectable		 3hs4A-5fx8A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		3 / 3 TRP A 439
ALA A 447
VAL A 300
 None
 1.02A 3l8lA-5fx8A:
undetectable
3l8lB-5fx8A:
undetectable		 3l8lA-5fx8A:
2.18
3l8lB-5fx8A:
3.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		3 / 3 HIS A 301
PHE A 369
PHE A 452
 None
 0.67A 3lk0D-5fx8A:
undetectable		 3lk0D-5fx8A:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		4 / 7 PHE A 452
ILE A  92
THR A 307
THR A 474
 None
 1.27A 3nxuA-5fx8A:
undetectable		 3nxuA-5fx8A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		5 / 12 THR A  80
GLY A 359
LEU A 336
GLN A 287
VAL A 291
 None
 1.20A 3t7vA-5fx8A:
undetectable		 3t7vA-5fx8A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 5fx8 LINOLEATE
11-LIPOXYGENASE
ZONADHESIN
(Gaeumannomyces
avenae;
Komagataella
phaffii) 		4 / 7 GLY A 406
ALA A 407
ALA U 275
ARG A 574
 None
 0.85A 3ur0B-5fx8A:
undetectable		 3ur0B-5fx8A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V2J_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		5 / 11 GLN A 287
HIS A 290
HIS A 294
PHE A 347
LEU A 336
 None
MN  A1000 (-3.5A)
MN  A1000 (-3.3A)
None
None
 1.16A 3v2jA-5fx8A:
undetectable		 3v2jA-5fx8A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V2M_A_AZMA303_1
(CARBONIC ANHYDRASE 2)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		5 / 10 GLN A 287
HIS A 290
HIS A 294
PHE A 347
LEU A 336
 None
MN  A1000 (-3.5A)
MN  A1000 (-3.3A)
None
None
 1.19A 3v2mA-5fx8A:
undetectable		 3v2mA-5fx8A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		5 / 11 MET A 412
ASN A 572
GLY A 567
PRO A 313
GLY A 316
 None
 1.30A 4a6nB-5fx8A:
undetectable		 4a6nB-5fx8A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		5 / 11 MET A 412
ASN A 572
GLY A 567
PRO A 313
GLY A 316
 None
 1.31A 4a6nC-5fx8A:
undetectable		 4a6nC-5fx8A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5fx8 ZONADHESIN
(Komagataella
phaffii) 		4 / 7 ASP U 210
GLY U 262
THR U 265
ILE U 266
 None
 0.81A 4acaC-5fx8U:
undetectable		 4acaC-5fx8U:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		4 / 7 PHE A 238
PHE A 247
PHE A 164
LEU A 169
 None
 1.09A 4ejgA-5fx8A:
undetectable		 4ejgA-5fx8A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		5 / 11 LEU A 560
ASN A 564
ALA A 571
PHE A 411
PHE A 415
 None
 1.34A 4evrA-5fx8A:
undetectable		 4evrA-5fx8A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		4 / 8 PHE A 415
VAL A 317
LEU A 463
HIS A 312
 None
 1.23A 4f5zA-5fx8A:
undetectable		 4f5zA-5fx8A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5fx8 LINOLEATE
11-LIPOXYGENASE
ZONADHESIN
(Gaeumannomyces
avenae;
Komagataella
phaffii) 		4 / 7 ASP A 400
ASN U 197
GLU U 257
GLU A 585
 None
 1.20A 4fexB-5fx8A:
undetectable		 4fexB-5fx8A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0C_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		5 / 11 GLN A 287
HIS A 290
HIS A 294
PHE A 347
LEU A 336
 None
MN  A1000 (-3.5A)
MN  A1000 (-3.3A)
None
None
 1.19A 4g0cA-5fx8A:
undetectable		 4g0cA-5fx8A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_B_SFYB806_0
(SEPIAPTERIN
REDUCTASE)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		5 / 11 LEU A 137
LEU A 495
TYR A 138
PRO A 497
ALA A 529
 None
 1.46A 4hwkB-5fx8A:
undetectable		 4hwkB-5fx8A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		5 / 12 LEU A 137
LEU A 495
TYR A 138
PRO A 497
ALA A 529
 None
 1.46A 4hwkC-5fx8A:
undetectable		 4hwkC-5fx8A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_D_SFYD803_0
(SEPIAPTERIN
REDUCTASE)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		5 / 11 LEU A 137
LEU A 495
TYR A 138
PRO A 497
ALA A 529
 None
 1.42A 4hwkD-5fx8A:
undetectable		 4hwkD-5fx8A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		4 / 7 ASN A 612
PRO A 613
PHE A 615
PHE A 555
 None
 1.48A 4v32C-5fx8A:
undetectable		 4v32C-5fx8A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		4 / 5 TYR A 289
PHE A 397
HIS A 478
PRO A 173
 None
None
MN  A1000 (-3.4A)
None
 1.22A 5csyB-5fx8A:
undetectable		 5csyB-5fx8A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		4 / 6 PHE A 602
SER A 597
ARG A 589
GLY A 590
 None
 0.95A 5o4yF-5fx8A:
undetectable		 5o4yF-5fx8A:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 5fx8 LINOLEATE
11-LIPOXYGENASE
(Gaeumannomyces
avenae) 		5 / 10 PRO A 494
HIS A 496
GLY A 127
ILE A 122
ALA A 529
 None
 1.15A 5vyhA-5fx8A:
undetectable		 5vyhA-5fx8A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5fx8 ZONADHESIN
(Komagataella
phaffii) 		5 / 12 ALA U 217
PRO U 247
ASP U 187
PRO U 230
PHE U 228
 None
 1.07A 5zvgA-5fx8U:
undetectable		 5zvgA-5fx8U:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5fx8 ZONADHESIN
(Komagataella
phaffii) 		5 / 12 ALA U 217
PRO U 247
ASP U 187
PRO U 230
PHE U 228
 None
 1.06A 5zvgB-5fx8U:
undetectable		 5zvgB-5fx8U:
21.19