SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fxe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 5fxe EUGENOL OXIDASE
(Rhodococcus
jostii) 		4 / 7 SER A  99
PRO A  54
ALA A  95
ALA A  51
 None
 1.02A 1k5qA-5fxeA:
undetectable
1k5qB-5fxeA:
undetectable		 1k5qA-5fxeA:
17.59
1k5qB-5fxeA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5fxe EUGENOL OXIDASE
(Rhodococcus
jostii) 		4 / 5 SER A  55
PHE A 521
VAL A   9
PHE A  14
 None
 1.21A 1oipA-5fxeA:
undetectable		 1oipA-5fxeA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 5fxe EUGENOL OXIDASE
(Rhodococcus
jostii) 		5 / 12 ILE A 337
ALA A 340
MET A 261
PHE A 244
PHE A 319
 None
 1.36A 1y0xX-5fxeA:
undetectable		 1y0xX-5fxeA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 5fxe EUGENOL OXIDASE
(Rhodococcus
jostii) 		5 / 12 PRO A 511
GLY A 512
LEU A 503
ASP A 504
PHE A 219
 None
 1.40A 2b9eA-5fxeA:
undetectable		 2b9eA-5fxeA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFM_A_TOPA1290_1
(PTERIDINE REDUCTASE
1)		 5fxe EUGENOL OXIDASE
(Rhodococcus
jostii) 		5 / 9 ASP A 365
LEU A 152
LEU A 381
LEU A 438
HIS A 390
 None
FAD  A 600 (-4.7A)
FAD  A 600 (-4.8A)
CIY  A 602 (-4.8A)
FAD  A 600 ( 2.6A)
 1.42A 2bfmA-5fxeA:
undetectable
2bfmD-5fxeA:
undetectable		 2bfmA-5fxeA:
21.70
2bfmD-5fxeA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		 5fxe EUGENOL OXIDASE
(Rhodococcus
jostii) 		5 / 12 ALA A  51
TRP A 517
PHE A 521
GLY A 100
THR A   4
 None
GOL  A1530 (-3.5A)
None
None
None
 1.42A 2xffA-5fxeA:
undetectable		 2xffA-5fxeA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 5fxe EUGENOL OXIDASE
(Rhodococcus
jostii) 		3 / 3 ASP A 216
PHE A 219
LEU A 162
 GOL  A1529 ( 4.4A)
None
FAD  A 600 (-4.3A)
 0.69A 2zi9A-5fxeA:
undetectable		 2zi9A-5fxeA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 5fxe EUGENOL OXIDASE
(Rhodococcus
jostii) 		5 / 12 LEU A 264
ARG A 265
ILE A 337
ALA A 269
LEU A 323
 None
 0.94A 3gwvA-5fxeA:
undetectable		 3gwvA-5fxeA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5fxe EUGENOL OXIDASE
(Rhodococcus
jostii) 		5 / 12 SER A 101
SER A  55
PHE A 521
ILE A 508
VAL A   9
 None
 1.04A 3w68A-5fxeA:
undetectable		 3w68A-5fxeA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5fxe EUGENOL OXIDASE
(Rhodococcus
jostii) 		5 / 12 VAL A 287
SER A 288
TRP A 384
LEU A 277
VAL A 276
 None
 1.03A 4ib4A-5fxeA:
undetectable		 4ib4A-5fxeA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOS_A_4KOA201_1
(UNCHARACTERIZED
PROTEIN)		 5fxe EUGENOL OXIDASE
(Rhodococcus
jostii) 		5 / 12 PRO A   6
ARG A 520
GLY A  77
ILE A  72
PHE A  14
 None
 1.44A 4kosA-5fxeA:
3.3		 4kosA-5fxeA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5fxe EUGENOL OXIDASE
(Rhodococcus
jostii) 		3 / 3 ASP A  42
LYS A  87
LEU A 152
 None
None
FAD  A 600 (-4.7A)
 0.97A 4ptjA-5fxeA:
undetectable		 4ptjA-5fxeA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5fxe EUGENOL OXIDASE
(Rhodococcus
jostii) 		4 / 5 ALA A 423
ARG A 278
ALA A 285
GLU A 378
 None
CIY  A 602 ( 4.4A)
None
CIY  A 602 (-3.6A)
 1.19A 5a06C-5fxeA:
undetectable
5a06D-5fxeA:
undetectable		 5a06C-5fxeA:
19.78
5a06D-5fxeA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5fxe EUGENOL OXIDASE
(Rhodococcus
jostii) 		4 / 6 SER A 394
GLY A 515
ASP A 479
ARG A  97
 CIY  A 602 ( 4.4A)
None
GOL  A1530 (-3.5A)
GOL  A1530 ( 4.6A)
 0.90A 5cdnT-5fxeA:
2.3
5cdnU-5fxeA:
undetectable		 5cdnT-5fxeA:
23.59
5cdnU-5fxeA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5fxe EUGENOL OXIDASE
(Rhodococcus
jostii) 		5 / 8 HIS A 361
GLY A 359
GLY A 360
VAL A 287
ASP A 365
 None
 1.40A 5f8yB-5fxeA:
undetectable		 5f8yB-5fxeA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5fxe EUGENOL OXIDASE
(Rhodococcus
jostii) 		5 / 9 HIS A 361
GLY A 359
GLY A 360
VAL A 287
ASP A 365
 None
 1.47A 5f8yB-5fxeA:
undetectable		 5f8yB-5fxeA:
13.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FXF_A_BEZA601_0
(EUGENOL OXIDASE)		 5fxe EUGENOL OXIDASE
(Rhodococcus
jostii) 		9 / 9 TYR A  91
VAL A 166
TYR A 168
GLN A 425
ILE A 427
VAL A 436
LEU A 438
TYR A 471
ARG A 472
 CIY  A 602 (-3.9A)
FAD  A 600 (-4.0A)
FAD  A 600 ( 4.5A)
CIY  A 602 (-3.5A)
None
CIY  A 602 (-4.8A)
CIY  A 602 (-4.8A)
CIY  A 602 (-4.5A)
FAD  A 600 ( 3.0A)
 0.23A 5fxfA-5fxeA:
65.6		 5fxfA-5fxeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FXF_B_BEZB601_0
(EUGENOL OXIDASE)		 5fxe EUGENOL OXIDASE
(Rhodococcus
jostii) 		10 / 10 TYR A  91
ASP A 151
VAL A 166
TYR A 168
GLN A 425
ILE A 427
VAL A 436
LEU A 438
TYR A 471
ARG A 472
 CIY  A 602 (-3.9A)
FAD  A 600 ( 3.5A)
FAD  A 600 (-4.0A)
FAD  A 600 ( 4.5A)
CIY  A 602 (-3.5A)
None
CIY  A 602 (-4.8A)
CIY  A 602 (-4.8A)
CIY  A 602 (-4.5A)
FAD  A 600 ( 3.0A)
 0.27A 5fxfB-5fxeA:
64.7		 5fxfB-5fxeA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5fxe EUGENOL OXIDASE
(Rhodococcus
jostii) 		3 / 3 SER A 101
SER A  55
PHE A 521
 None
 0.94A 5mugA-5fxeA:
undetectable		 5mugA-5fxeA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 5fxe EUGENOL OXIDASE
(Rhodococcus
jostii) 		4 / 5 ALA A  56
VAL A  58
PHE A  14
ILE A  69
 None
 1.01A 5of1B-5fxeA:
undetectable		 5of1B-5fxeA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 5fxe EUGENOL OXIDASE
(Rhodococcus
jostii) 		3 / 3 TRP A 384
MET A 282
ASN A 279
 None
CIY  A 602 ( 4.0A)
None
 1.15A 5uc1B-5fxeA:
undetectable		 5uc1B-5fxeA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 5fxe EUGENOL OXIDASE
(Rhodococcus
jostii) 		3 / 3 TRP A 384
MET A 282
ASN A 279
 None
CIY  A 602 ( 4.0A)
None
 1.11A 5uc1A-5fxeA:
undetectable		 5uc1A-5fxeA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 5fxe EUGENOL OXIDASE
(Rhodococcus
jostii) 		4 / 8 GLY A 165
ILE A 427
ASP A 151
ASP A 148
 FAD  A 600 (-3.1A)
None
FAD  A 600 ( 3.5A)
None
 0.87A 5vlmH-5fxeA:
undetectable		 5vlmH-5fxeA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 5fxe EUGENOL OXIDASE
(Rhodococcus
jostii) 		5 / 12 LEU A 477
GLY A  92
ALA A 476
ASP A  42
PRO A  43
 None
 1.30A 5x6yC-5fxeA:
undetectable		 5x6yC-5fxeA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 5fxe EUGENOL OXIDASE
(Rhodococcus
jostii) 		4 / 8 GLY A 231
GLN A 178
THR A 179
TYR A 171
 None
GOL  A1529 (-3.3A)
None
None
 1.16A 6eqpA-5fxeA:
undetectable		 6eqpA-5fxeA:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 5fxe EUGENOL OXIDASE
(Rhodococcus
jostii) 		5 / 12 ARG A 290
VAL A 385
ASN A 419
MET A 455
ILE A 445
 None
 1.43A 6gsdA-5fxeA:
undetectable		 6gsdA-5fxeA:
10.36