SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fxv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_B_DVAB6_0
(GRAMICIDIN A)		 5fxv HISTONE DEMETHYLASE
UTY
(Homo
sapiens) 		4 / 4 VAL A1060
TRP A1186
ALA A1057
VAL A1059
 None
 1.26A 1gmkA-5fxvA:
undetectable
1gmkB-5fxvA:
undetectable		 1gmkA-5fxvA:
2.78
1gmkB-5fxvA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 5fxv HISTONE DEMETHYLASE
UTY
(Homo
sapiens) 		4 / 4 GLU A1095
GLY A1170
THR A1171
GLU A1118
 MN  A2346 (-2.7A)
None
EDO  A2353 ( 4.9A)
None
 1.12A 3e9xA-5fxvA:
undetectable		 3e9xA-5fxvA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 5fxv HISTONE DEMETHYLASE
UTY
(Homo
sapiens) 		5 / 9 ILE A1104
ILE A1106
GLU A1049
LEU A1050
LYS A1052
 None
 1.25A 3f78A-5fxvA:
undetectable		 3f78A-5fxvA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		 5fxv HISTONE DEMETHYLASE
UTY
(Homo
sapiens) 		5 / 9 ILE A1104
ILE A1106
GLU A1049
LEU A1050
LYS A1052
 None
 1.33A 3f78B-5fxvA:
undetectable		 3f78B-5fxvA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 5fxv HISTONE DEMETHYLASE
UTY
(Homo
sapiens) 		4 / 5 ASN A1287
ARG A1226
ASN A1223
ALA A1275
 None
 1.47A 3frqA-5fxvA:
undetectable		 3frqA-5fxvA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 5fxv HISTONE DEMETHYLASE
UTY
(Homo
sapiens) 		4 / 6 ARG A1089
PHE A1026
ASP A 960
PRO A 954
 None
 0.96A 3jqaA-5fxvA:
undetectable		 3jqaA-5fxvA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 5fxv HISTONE DEMETHYLASE
UTY
(Homo
sapiens) 		4 / 6 ARG A1089
PHE A1026
ASP A 960
PRO A 954
 None
 1.09A 3jqaB-5fxvA:
undetectable		 3jqaB-5fxvA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 5fxv HISTONE DEMETHYLASE
UTY
(Homo
sapiens) 		4 / 6 ARG A1089
PHE A1026
ASP A 960
PRO A 954
 None
 0.96A 3jqaC-5fxvA:
undetectable		 3jqaC-5fxvA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 5fxv HISTONE DEMETHYLASE
UTY
(Homo
sapiens) 		4 / 6 ARG A1089
PHE A1026
ASP A 960
PRO A 954
 None
 0.95A 3jqaD-5fxvA:
undetectable		 3jqaD-5fxvA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5fxv HISTONE DEMETHYLASE
UTY
(Homo
sapiens) 		3 / 3 LYS A1197
GLU A1201
TRP A1121
 None
 1.31A 3v4tH-5fxvA:
undetectable		 3v4tH-5fxvA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5fxv HISTONE DEMETHYLASE
UTY
(Homo
sapiens) 		4 / 6 SER A1088
THR A1028
ILE A1029
THR A1033
 None
 1.07A 4acbC-5fxvA:
undetectable		 4acbC-5fxvA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5fxv HISTONE DEMETHYLASE
UTY
(Homo
sapiens) 		4 / 7 ARG A 896
ASP A 897
LEU A 892
SER A 889
 None
 1.30A 5uxcA-5fxvA:
undetectable		 5uxcA-5fxvA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 5fxv HISTONE DEMETHYLASE
UTY
(Homo
sapiens) 		4 / 5 LEU A1257
VAL A1264
GLU A1323
LEU A1288
 None
 1.00A 5xooB-5fxvA:
undetectable		 5xooB-5fxvA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 5fxv HISTONE DEMETHYLASE
UTY
(Homo
sapiens) 		4 / 7 GLN A1080
GLY A1075
VAL A1215
SER A1101
 None
None
None
MN  A2346 ( 4.6A)
 0.76A 6hu9S-5fxvA:
undetectable
6hu9q-5fxvA:
undetectable		 6hu9S-5fxvA:
11.57
6hu9q-5fxvA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 5fxv HISTONE DEMETHYLASE
UTY
(Homo
sapiens) 		4 / 6 THR A1192
LEU A1191
MET A1238
LEU A1066
 None
 1.10A 6mvxA-5fxvA:
undetectable
6mvxB-5fxvA:
2.0
6mvxC-5fxvA:
undetectable		 6mvxA-5fxvA:
21.46
6mvxB-5fxvA:
21.46
6mvxC-5fxvA:
21.46