SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fyg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 5fyg CYTOCHROME P450
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 THR A 183
VAL A 186
LEU A 187
LEU A 190
LEU A 466
 None
 0.86A 1mx1C-5fygA:
undetectable		 1mx1C-5fygA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 5fyg CYTOCHROME P450
(Marinobacter
hydrocarbonoclas
ticus) 		3 / 3 LEU A 294
PHE A 301
ARG A 270
 None
 0.45A 1xdkF-5fygA:
undetectable		 1xdkF-5fygA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5fyg CYTOCHROME P450
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 GLY A 240
GLY A 234
GLU A 242
GLN A 456
PHE A  78
 None
 1.44A 2akeA-5fygA:
undetectable		 2akeA-5fygA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5fyg CYTOCHROME P450
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 11 GLY A 240
GLY A 234
GLU A 242
GLN A 456
PHE A  78
 None
 1.43A 2dr2A-5fygA:
undetectable		 2dr2A-5fygA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 5fyg CYTOCHROME P450
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 ALA A 326
SER A 349
ALA A 428
THR A 316
LEU A 324
 None
None
HEM  A1475 (-3.5A)
HEM  A1475 (-4.5A)
None
 1.21A 2zifB-5fygA:
undetectable		 2zifB-5fygA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 5fyg CYTOCHROME P450
(Marinobacter
hydrocarbonoclas
ticus) 		3 / 3 PRO A 153
PHE A 148
LYS A 155
 None
HEM  A1475 (-4.8A)
None
 1.28A 3bjwG-5fygA:
undetectable		 3bjwG-5fygA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5fyg CYTOCHROME P450
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 5 LEU A  67
GLN A  84
HIS A  99
LEU A  92
 None
 1.14A 3ce6D-5fygA:
undetectable		 3ce6D-5fygA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 5fyg CYTOCHROME P450
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 ALA A 253
MET A 232
PHE A 260
ILE A 309
LEU A 215
 None
 1.13A 3ia4C-5fygA:
undetectable		 3ia4C-5fygA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 5fyg CYTOCHROME P450
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 ALA A 253
MET A 232
PHE A 260
ILE A 309
LEU A 215
 None
 1.15A 3ia4D-5fygA:
undetectable		 3ia4D-5fygA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 5fyg CYTOCHROME P450
(Marinobacter
hydrocarbonoclas
ticus) 		3 / 3 GLU A 335
GLU A 447
ASN A 445
 None
 0.92A 3lp9B-5fygA:
undetectable
3lp9D-5fygA:
undetectable		 3lp9B-5fygA:
17.77
3lp9D-5fygA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5fyg CYTOCHROME P450
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 8 LEU A 435
ILE A 446
VAL A 448
GLY A 323
 None
 0.86A 4eq4B-5fygA:
undetectable		 4eq4B-5fygA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 5fyg CYTOCHROME P450
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 8 GLY A 240
ALA A 244
LYS A  53
GLU A 246
 None
 0.67A 4hyfB-5fygA:
undetectable		 4hyfB-5fygA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 5fyg CYTOCHROME P450
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 HIS A 156
PHE A 148
ILE A 149
GLY A 312
LEU A 308
 HEM  A1475 (-3.8A)
HEM  A1475 (-4.8A)
HEM  A1475 (-4.1A)
HEM  A1475 (-3.4A)
None
 1.20A 5byjA-5fygA:
undetectable		 5byjA-5fygA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 5fyg CYTOCHROME P450
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 ILE A 446
PHE A 443
ILE A 439
VAL A 202
ALA A 201
 None
 0.78A 5km9B-5fygA:
undetectable		 5km9B-5fygA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 5fyg CYTOCHROME P450
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 ALA A 326
GLY A 323
GLU A 437
LEU A 435
GLU A 438
 None
 1.17A 5nwuA-5fygA:
undetectable		 5nwuA-5fygA:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5fyg CYTOCHROME P450
(Marinobacter
hydrocarbonoclas
ticus) 		3 / 3 HIS A 412
GLU A 350
ASN A 346
 None
 0.99A 5wbvA-5fygA:
undetectable		 5wbvA-5fygA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5fyg CYTOCHROME P450
(Marinobacter
hydrocarbonoclas
ticus) 		3 / 3 HIS A 412
GLU A 350
ASN A 346
 None
 0.99A 5wbvB-5fygA:
undetectable		 5wbvB-5fygA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 5fyg CYTOCHROME P450
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 4 ARG A 433
GLU A 437
GLU A 176
ARG A 180
 None
 1.30A 6fk2A-5fygA:
undetectable		 6fk2A-5fygA:
13.72