SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fyj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AZM_A_AZMA262_1
(CARBONIC ANHYDRASE I)		 5fyj GP120 ENV ECTODOMAIN
GP41 ENV ECTODOMAIN
(Human
immunodeficiency
virus
1) 		4 / 8 HIS G  72
HIS B 564
THR G  63
HIS G  66
 None
 1.05A 1azmA-5fyjG:
undetectable		 1azmA-5fyjG:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 5fyj GP120 ENV ECTODOMAIN
(Human
immunodeficiency
virus
1) 		5 / 12 PRO G 437
THR G 320
ASN G 302
ARG G 379
ALA G 440
 None
None
None
MAN  G2626 (-3.0A)
None
 1.31A 2axnA-5fyjG:
undetectable		 2axnA-5fyjG:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 5fyj GP120 ENV ECTODOMAIN
GP41 ENV ECTODOMAIN
(Human
immunodeficiency
virus
1) 		4 / 4 THR G  37
VAL G  42
GLY B 531
THR B 529
 None
 1.00A 3cflA-5fyjG:
undetectable		 3cflA-5fyjG:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5fyj GP120 ENV ECTODOMAIN
(Human
immunodeficiency
virus
1) 		3 / 3 ASN G  94
MET G 271
PHE G 233
 None
 1.03A 3g4lD-5fyjG:
undetectable		 3g4lD-5fyjG:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 5fyj GP120 ENV ECTODOMAIN
(Human
immunodeficiency
virus
1) 		3 / 3 ASN G 442
ASN G 302
GLU G 381
 NAG  G4421 (-1.8A)
None
None
 0.92A 3kpdC-5fyjG:
undetectable		 3kpdC-5fyjG:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5fyj GP120 ENV ECTODOMAIN
(Human
immunodeficiency
virus
1) 		3 / 3 ASN G 442
ASN G 302
GLU G 381
 NAG  G4421 (-1.8A)
None
None
 0.83A 3kpdB-5fyjG:
undetectable		 3kpdB-5fyjG:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 5fyj GP41 ENV ECTODOMAIN
(Human
immunodeficiency
virus
1) 		3 / 3 GLU B 630
GLU B 621
ASN B 625
 NAG  B6251 (-4.3A)
NAG  B6161 ( 3.6A)
NAG  B6251 (-1.9A)
 0.83A 3lp9B-5fyjB:
undetectable
3lp9D-5fyjB:
undetectable		 3lp9B-5fyjB:
17.30
3lp9D-5fyjB:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 5fyj GP120 ENV ECTODOMAIN
(Human
immunodeficiency
virus
1) 		5 / 12 PHE G 176
PHE G 159
PHE G 309
ALA G 316
ALA G 204
 None
 1.07A 3nxuA-5fyjG:
undetectable		 3nxuA-5fyjG:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 5fyj GP120 ENV ECTODOMAIN
(Human
immunodeficiency
virus
1) 		5 / 12 PHE G 176
PHE G 159
PHE G 309
ALA G 316
ALA G 204
 None
 1.06A 3nxuB-5fyjG:
undetectable		 3nxuB-5fyjG:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 5fyj GP120 ENV ECTODOMAIN
(Human
immunodeficiency
virus
1) 		4 / 6 ILE G 272
ILE G 333
TRP G 338
MET G 341
 None
 1.11A 3welA-5fyjG:
undetectable		 3welA-5fyjG:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5fyj GP41 ENV ECTODOMAIN
GP120 ENV ECTODOMAIN
(Human
immunodeficiency
virus
1;
Human
immunodeficiency
virus
1) 		4 / 5 LEU G  86
GLY B 524
THR B 536
VAL B 539
 None
 0.83A 3wriA-5fyjG:
undetectable		 3wriA-5fyjG:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 5fyj GP41 ENV ECTODOMAIN
GP120 ENV ECTODOMAIN
(Human
immunodeficiency
virus
1;
Human
immunodeficiency
virus
1) 		4 / 5 LEU G  86
GLY B 524
THR B 536
VAL B 539
 None
 0.85A 3wriB-5fyjG:
undetectable		 3wriB-5fyjG:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 5fyj GP41 ENV ECTODOMAIN
GP120 ENV ECTODOMAIN
(Human
immunodeficiency
virus
1;
Human
immunodeficiency
virus
1) 		4 / 5 LEU G  86
GLY B 524
THR B 536
VAL B 539
 None
 0.75A 3wrkD-5fyjG:
undetectable		 3wrkD-5fyjG:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5fyj GP120 ENV ECTODOMAIN
(Human
immunodeficiency
virus
1) 		4 / 8 VAL G 455
ALA G 471
GLY G 473
GLY G 367
 None
 0.75A 5e26C-5fyjG:
undetectable
5e26D-5fyjG:
undetectable		 5e26C-5fyjG:
21.33
5e26D-5fyjG:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 5fyj GP41 ENV ECTODOMAIN
(Human
immunodeficiency
virus
1) 		4 / 7 GLY B 594
TRP B 596
ASP B 589
TYR B 586
 None
None
CIT  B1666 (-3.2A)
None
 1.23A 5vlmG-5fyjB:
undetectable		 5vlmG-5fyjB:
23.40