SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fyn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 5fyn PUUMALA VIRUS GN
GLYCOPROTEIN
(Puumala
orthohantavirus) 		5 / 9 GLY A  43
ILE A  46
THR A 369
PRO A 265
ILE A 256
 None
 1.36A 2nnhB-5fynA:
undetectable		 2nnhB-5fynA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 5fyn PUUMALA VIRUS GN
GLYCOPROTEIN
(Puumala
orthohantavirus) 		5 / 11 GLY A 372
GLY A 289
ILE A 268
LEU A 280
SER A 281
 None
 0.96A 3dcmX-5fynA:
undetectable		 3dcmX-5fynA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)		 5fyn PUUMALA VIRUS GN
GLYCOPROTEIN
(Puumala
orthohantavirus) 		5 / 12 ILE A 347
LEU A 338
GLY A 323
THR A 365
GLY A 351
 None
 0.83A 3uq6A-5fynA:
undetectable		 3uq6A-5fynA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 5fyn PUUMALA VIRUS GN
GLYCOPROTEIN
(Puumala
orthohantavirus) 		5 / 12 ILE A 347
LEU A 338
GLY A 323
THR A 365
GLY A 351
 None
 0.81A 3vaqA-5fynA:
undetectable		 3vaqA-5fynA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 5fyn PUUMALA VIRUS GN
GLYCOPROTEIN
(Puumala
orthohantavirus) 		5 / 12 ILE A 347
LEU A 338
GLY A 323
THR A 365
GLY A 351
 None
 0.81A 3vasA-5fynA:
undetectable		 3vasA-5fynA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 5fyn PUUMALA VIRUS GN
GLYCOPROTEIN
(Puumala
orthohantavirus) 		4 / 8 GLY A 351
GLN A 143
THR A  86
SER A 334
 None
NAG  A1382 ( 4.7A)
None
None
 1.03A 6eqpA-5fynA:
undetectable		 6eqpA-5fynA:
11.17