SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fyq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		4 / 5 LYS A 338
GLU A 342
ALA A 332
LEU A 334
 None
 1.13A 1eta1-5fyqA:
undetectable		 1eta1-5fyqA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		4 / 5 LYS A 338
GLU A 342
ALA A 332
LEU A 334
 None
 1.14A 1eta2-5fyqA:
undetectable		 1eta2-5fyqA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		4 / 6 LYS A 338
GLU A 342
ALA A 332
LEU A 334
 None
 1.16A 1etb1-5fyqA:
undetectable		 1etb1-5fyqA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 6 ALA A  85
SER A  88
ASN A 168
ILE A 169
ASP A 170
 SO4  A1357 ( 4.1A)
None
None
None
None
 0.23A 1yc2A-5fyqA:
20.1		 1yc2A-5fyqA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 6 ALA A  85
SER A  88
PHE A  96
ASN A 168
ASP A 170
 SO4  A1357 ( 4.1A)
None
None
None
None
 1.00A 1yc2A-5fyqA:
20.1		 1yc2A-5fyqA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 5 ALA A  85
PHE A  96
ASN A 168
ILE A 169
ASP A 170
 SO4  A1357 ( 4.1A)
None
None
None
None
 1.03A 1yc2D-5fyqA:
20.1		 1yc2D-5fyqA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 7 ILE A  93
PHE A  96
ASN A 168
ILE A 169
ASP A 170
 None
 0.84A 1yc2E-5fyqA:
21.0		 1yc2E-5fyqA:
26.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		7 / 7 ALA A  85
SER A  88
ILE A  93
ASP A  95
ASN A 168
ILE A 169
ASP A 170
 SO4  A1357 ( 4.1A)
None
None
SO4  A1357 ( 4.8A)
None
None
None
 0.25A 1yc5A-5fyqA:
22.0		 1yc5A-5fyqA:
30.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		4 / 5 LEU A 331
LEU A 335
LEU A 154
LEU A 155
 None
 0.99A 2ab2B-5fyqA:
undetectable		 2ab2B-5fyqA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_1
(HYPOTHETICAL PROTEIN
LMO1582)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		4 / 4 THR A 166
THR A 262
ASP A  95
ASP A 105
 None
SO4  A1357 (-3.5A)
SO4  A1357 ( 4.8A)
None
 1.04A 2f8lA-5fyqA:
undetectable		 2f8lA-5fyqA:
22.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 5 ALA A  85
ILE A  93
ASN A 168
ILE A 169
ASP A 170
 SO4  A1357 ( 4.1A)
None
None
None
None
 0.36A 2h4jA-5fyqA:
21.9		 2h4jA-5fyqA:
30.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		4 / 6 THR A 166
THR A 262
ASP A  95
ASP A 105
 None
SO4  A1357 (-3.5A)
SO4  A1357 ( 4.8A)
None
 1.03A 2okcA-5fyqA:
2.2		 2okcA-5fyqA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		4 / 6 THR A 166
THR A 262
ASP A  95
ASP A 105
 None
SO4  A1357 (-3.5A)
SO4  A1357 ( 4.8A)
None
 1.12A 2okcB-5fyqA:
2.2		 2okcB-5fyqA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		4 / 8 TYR A 165
LEU A 272
LYS A 275
ALA A 276
 None
 1.01A 2wekA-5fyqA:
5.8		 2wekA-5fyqA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 LEU A 331
LEU A 154
LEU A 155
ILE A 285
LEU A 329
 None
 1.20A 3olsB-5fyqA:
undetectable		 3olsB-5fyqA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 8 ASN A 168
ASP A  95
SER A  98
GLU A 116
GLU A 120
 None
SO4  A1357 ( 4.8A)
None
None
None
 1.42A 3sg9B-5fyqA:
undetectable		 3sg9B-5fyqA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_1
(ADENOSINE KINASE)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 0.90A 3uboB-5fyqA:
5.0		 3uboB-5fyqA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		4 / 4 ASN A 168
ALA A  85
GLY A  84
THR A 262
 None
SO4  A1357 ( 4.1A)
SO4  A1357 ( 4.3A)
SO4  A1357 (-3.5A)
 1.32A 4bboC-5fyqA:
undetectable		 4bboC-5fyqA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_1
(SUGAR KINASE PROTEIN)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 0.89A 4e3aA-5fyqA:
undetectable		 4e3aA-5fyqA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_1
(SUGAR KINASE PROTEIN)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		6 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
GLY A 322
 None
 1.38A 4e3aB-5fyqA:
undetectable		 4e3aB-5fyqA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 GLY A 306
GLY A 305
LEU A 283
PRO A 281
LEU A  59
 None
 0.88A 4fp9A-5fyqA:
undetectable		 4fp9A-5fyqA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 GLY A 306
GLY A 305
LEU A 283
PRO A 281
LEU A  59
 None
 0.89A 4fp9C-5fyqA:
undetectable		 4fp9C-5fyqA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 GLY A 306
GLY A 305
LEU A 283
PRO A 281
LEU A  59
 None
 0.88A 4fp9D-5fyqA:
undetectable		 4fp9D-5fyqA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 GLY A 306
GLY A 305
LEU A 283
PRO A 281
LEU A  59
 None
 0.88A 4fp9F-5fyqA:
undetectable		 4fp9F-5fyqA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 GLY A 306
GLY A 305
LEU A 283
PRO A 281
LEU A  59
 None
 0.87A 4fzvA-5fyqA:
undetectable		 4fzvA-5fyqA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_B_ADNB500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 0.86A 4jkuB-5fyqA:
undetectable		 4jkuB-5fyqA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_A_ADNA401_1
(SUGAR KINASE)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 0.88A 4k8pA-5fyqA:
undetectable		 4k8pA-5fyqA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_B_ADNB401_1
(SUGAR KINASE)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 0.88A 4k8pB-5fyqA:
undetectable		 4k8pB-5fyqA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_A_ADNA401_1
(SUGAR KINASE)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 0.87A 4k8tA-5fyqA:
4.6		 4k8tA-5fyqA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_B_ADNB401_1
(SUGAR KINASE)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 0.87A 4k8tB-5fyqA:
undetectable		 4k8tB-5fyqA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_A_ADNA401_1
(SUGAR KINASE)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 0.88A 4k93A-5fyqA:
undetectable		 4k93A-5fyqA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_B_ADNB402_1
(SUGAR KINASE)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 0.89A 4k93B-5fyqA:
undetectable		 4k93B-5fyqA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_A_ADNA401_1
(SUGAR KINASE)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 0.87A 4k9cA-5fyqA:
5.0		 4k9cA-5fyqA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_B_ADNB401_1
(SUGAR KINASE)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 0.88A 4k9cB-5fyqA:
undetectable		 4k9cB-5fyqA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_A_ADNA401_1
(SUGAR KINASE)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 0.90A 4k9iA-5fyqA:
4.9		 4k9iA-5fyqA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_B_ADNB401_1
(SUGAR KINASE)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 0.89A 4k9iB-5fyqA:
4.6		 4k9iB-5fyqA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 0.87A 4kadA-5fyqA:
undetectable		 4kadA-5fyqA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 0.88A 4kadB-5fyqA:
4.6		 4kadB-5fyqA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 0.88A 4lbxA-5fyqA:
undetectable		 4lbxA-5fyqA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 0.89A 4lbxB-5fyqA:
undetectable		 4lbxB-5fyqA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 0.87A 4lc4A-5fyqA:
undetectable		 4lc4A-5fyqA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		5 / 12 ILE A  87
GLY A 261
GLY A  86
THR A 146
LEU A 172
 None
 0.87A 4lc4B-5fyqA:
4.7		 4lc4B-5fyqA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		4 / 5 CYH A 148
LEU A 258
LEU A 284
LEU A 331
 None
 1.27A 4n09D-5fyqA:
5.8		 4n09D-5fyqA:
22.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		4 / 5 PHE A 119
HIS A 187
LEU A 239
PRO A 268
 None
 1.14A 4o8zA-5fyqA:
31.0		 4o8zA-5fyqA:
44.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		4 / 7 ILE A  93
ASN A 168
ILE A 169
ASP A 170
 None
 0.31A 4rmjA-5fyqA:
39.4		 4rmjA-5fyqA:
84.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		4 / 7 ILE A  93
PHE A  96
ASN A 168
ASP A 170
 None
 0.63A 4rmjA-5fyqA:
39.4		 4rmjA-5fyqA:
84.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens) 		4 / 5 GLU A 137
ALA A 133
GLU A 108
ASN A 106
 None
 1.23A 5dwkC-5fyqA:
undetectable		 5dwkC-5fyqA:
15.22