SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fyr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 5fyr PHOSPHOINOSITOL-SPEC
IFIC PHOSPHOLIPASE C
(Pseudomonas
sp.) 		4 / 4 HIS A 111
LEU A 148
LEU A 186
LEU A  49
 None
 1.18A 1a4lD-5fyrA:
undetectable		 1a4lD-5fyrA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5fyr PHOSPHOINOSITOL-SPEC
IFIC PHOSPHOLIPASE C
(Pseudomonas
sp.) 		4 / 6 ALA A  96
GLU A  95
LEU A 139
LEU A 118
 None
 0.91A 1mt1D-5fyrA:
undetectable
1mt1E-5fyrA:
undetectable		 1mt1D-5fyrA:
16.61
1mt1E-5fyrA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 5fyr PHOSPHOINOSITOL-SPEC
IFIC PHOSPHOLIPASE C
(Pseudomonas
sp.) 		3 / 3 ASP A 119
ASN A  27
SER A 191
 INS  A 301 ( 3.1A)
CA  A 401 ( 3.0A)
None
 0.84A 3lslA-5fyrA:
undetectable
3lslD-5fyrA:
undetectable		 3lslA-5fyrA:
19.69
3lslD-5fyrA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 5fyr PHOSPHOINOSITOL-SPEC
IFIC PHOSPHOLIPASE C
(Pseudomonas
sp.) 		3 / 3 SER A 191
ASP A 119
ASN A  27
 None
INS  A 301 ( 3.1A)
CA  A 401 ( 3.0A)
 0.92A 3lslA-5fyrA:
undetectable
3lslD-5fyrA:
undetectable		 3lslA-5fyrA:
19.69
3lslD-5fyrA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 5fyr PHOSPHOINOSITOL-SPEC
IFIC PHOSPHOLIPASE C
(Pseudomonas
sp.) 		4 / 5 LEU A 154
ILE A 258
MET A 238
PHE A  17
 None
 1.08A 4dc3B-5fyrA:
undetectable		 4dc3B-5fyrA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 5fyr PHOSPHOINOSITOL-SPEC
IFIC PHOSPHOLIPASE C
(Pseudomonas
sp.) 		3 / 3 TYR A 282
GLN A 275
TRP A 262
 None
None
INS  A 301 (-3.8A)
 1.02A 4kn2C-5fyrA:
undetectable		 4kn2C-5fyrA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 5fyr PHOSPHOINOSITOL-SPEC
IFIC PHOSPHOLIPASE C
(Pseudomonas
sp.) 		3 / 3 ARG A 131
ASP A  53
TRP A  66
 None
 1.02A 4xdqA-5fyrA:
undetectable		 4xdqA-5fyrA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		 5fyr PHOSPHOINOSITOL-SPEC
IFIC PHOSPHOLIPASE C
(Pseudomonas
sp.) 		4 / 7 TYR A  29
TYR A  33
GLU A  30
PHE A  37
 None
 1.02A 5aclA-5fyrA:
undetectable		 5aclA-5fyrA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5fyr PHOSPHOINOSITOL-SPEC
IFIC PHOSPHOLIPASE C
(Pseudomonas
sp.) 		4 / 6 VAL A 101
LEU A 116
LEU A 186
LEU A  94
 None
 1.04A 6f6sA-5fyrA:
undetectable
6f6sB-5fyrA:
undetectable		 6f6sA-5fyrA:
15.07
6f6sB-5fyrA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5fyr PHOSPHOINOSITOL-SPEC
IFIC PHOSPHOLIPASE C
(Pseudomonas
sp.) 		4 / 8 ASP A  50
ARG A 260
VAL A  44
GLN A 275
 CA  A 401 (-2.2A)
INS  A 301 (-2.9A)
None
None
 1.05A 6fbvD-5fyrA:
undetectable		 6fbvD-5fyrA:
12.39