SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fz5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5fz5 TATA-BOX-BINDING
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 THR O 112
VAL O 122
THR O 124
VAL O  71
 None
 0.32A 3em0B-5fz5O:
undetectable		 3em0B-5fz5O:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 5fz5 TRANSCRIPTION
INITIATION FACTOR
IIB
(Saccharomyces
cerevisiae) 		3 / 3 ARG M 241
ILE M 282
THR M 308
 None
 0.53A 3ia4D-5fz5M:
undetectable		 3ia4D-5fz5M:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 5fz5 TATA-BOX-BINDING
PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 LEU O 204
LEU O 214
VAL O 213
SER O 163
LEU O 172
 None
 1.21A 3m7rA-5fz5O:
undetectable		 3m7rA-5fz5O:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5fz5 TATA-BOX-BINDING
PROTEIN
(Saccharomyces
cerevisiae) 		5 / 11 PHE O 155
VAL O  74
ILE O  70
ALA O 126
THR O 111
 None
 1.13A 3mdtB-5fz5O:
undetectable		 3mdtB-5fz5O:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC392_1
(TETX2 PROTEIN)		 5fz5 TATA-BOX-BINDING
PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 TYR O 195
GLU O 228
VAL O 166
ILE O  63
TYR O 231
 None
 1.08A 4a99A-5fz5O:
undetectable
4a99C-5fz5O:
undetectable		 4a99A-5fz5O:
23.33
4a99C-5fz5O:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 5fz5 TATA-BOX-BINDING
PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 ILE O 170
LEU O 175
ILE O 206
ILE O 212
VAL O 166
 None
 0.80A 4y0rA-5fz5O:
undetectable		 4y0rA-5fz5O:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 5fz5 TRANSCRIPTION
INITIATION FACTOR
IIB
(Saccharomyces
cerevisiae) 		3 / 3 CYH M 157
LYS M 155
HIS M 158
 None
 1.03A 5js5A-5fz5M:
undetectable		 5js5A-5fz5M:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 5fz5 TRANSCRIPTION
INITIATION FACTOR
IIF SUBUNIT ALPHA
TRANSCRIPTION
INITIATION FACTOR
IIF SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 5 LEU Q 103
THR R 105
PRO R  74
ARG R  72
 None
 1.25A 6ew0B-5fz5Q:
undetectable		 6ew0B-5fz5Q:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 5fz5 TRANSCRIPTION
INITIATION FACTOR
IIF SUBUNIT ALPHA
TRANSCRIPTION
INITIATION FACTOR
IIF SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 5 LEU Q 103
THR R 105
PRO R  74
ARG R  72
 None
 1.25A 6ew0D-5fz5Q:
undetectable		 6ew0D-5fz5Q:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 5fz5 TRANSCRIPTION
INITIATION FACTOR
IIF SUBUNIT ALPHA
TRANSCRIPTION
INITIATION FACTOR
IIF SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 5 LEU Q 103
THR R 105
PRO R  74
ARG R  72
 None
 1.25A 6ew0H-5fz5Q:
undetectable		 6ew0H-5fz5Q:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 5fz5 TRANSCRIPTION
INITIATION FACTOR
IIF SUBUNIT ALPHA
TRANSCRIPTION
INITIATION FACTOR
IIF SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 5 LEU Q 103
THR R 105
PRO R  74
ARG R  72
 None
 1.25A 6ew0I-5fz5Q:
undetectable		 6ew0I-5fz5Q:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5fz5 TRANSCRIPTION
INITIATION FACTOR
IIB
(Saccharomyces
cerevisiae) 		4 / 6 TYR M 154
ILE M 133
ALA M 128
ASP M 159
 None
 1.14A 6hu9m-5fz5M:
undetectable
6hu9q-5fz5M:
undetectable		 6hu9m-5fz5M:
21.26
6hu9q-5fz5M:
16.86