SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5fzo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C
(Homo
sapiens) 		3 / 3 TRP A2239
ALA A2233
VAL A2235
 None
 0.93A 1c4dC-5fzoA:
undetectable
1c4dD-5fzoA:
undetectable		 1c4dC-5fzoA:
4.22
1c4dD-5fzoA:
4.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C
(Homo
sapiens) 		4 / 8 ASN A2175
LEU A2170
ALA A2192
LEU A2168
 None
 0.74A 1hwiB-5fzoA:
undetectable		 1hwiB-5fzoA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C
(Homo
sapiens) 		4 / 8 ASN A2175
LEU A2170
ALA A2192
LEU A2168
 None
 0.74A 1hwiC-5fzoA:
undetectable		 1hwiC-5fzoA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C
(Homo
sapiens) 		4 / 6 TRP A2169
ARG A2379
GLY A2196
ASP A2456
 None
 1.21A 1kf6M-5fzoA:
undetectable
1kf6N-5fzoA:
undetectable		 1kf6M-5fzoA:
19.83
1kf6N-5fzoA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C
(Homo
sapiens) 		4 / 6 TRP A2169
ARG A2379
GLY A2455
ASP A2456
 None
 1.10A 1kf6M-5fzoA:
undetectable
1kf6N-5fzoA:
undetectable		 1kf6M-5fzoA:
19.83
1kf6N-5fzoA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQP_A_FCNA4002_1
(PROBABLE FOSFOMYCIN
RESISTANCE PROTEIN)		 5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C
(Homo
sapiens) 		5 / 10 HIS A2336
GLU A2338
HIS A2466
THR A2333
TRP A2391
 MN  A3499 (-3.4A)
MN  A3499 (-2.5A)
MN  A3499 (-3.4A)
None
None
 1.20A 1lqpA-5fzoA:
0.0
1lqpB-5fzoA:
0.0		 1lqpA-5fzoA:
19.32
1lqpB-5fzoA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQP_B_FCNB4001_1
(PROBABLE FOSFOMYCIN
RESISTANCE PROTEIN)		 5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C
(Homo
sapiens) 		5 / 10 HIS A2466
THR A2333
TRP A2391
HIS A2336
GLU A2338
 MN  A3499 (-3.4A)
None
None
MN  A3499 (-3.4A)
MN  A3499 (-2.5A)
 1.20A 1lqpA-5fzoA:
0.0
1lqpB-5fzoA:
0.0		 1lqpA-5fzoA:
19.32
1lqpB-5fzoA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C
(Homo
sapiens) 		4 / 7 PHE A2367
VAL A2349
GLY A2350
VAL A2323
 None
 1.01A 1t88A-5fzoA:
undetectable		 1t88A-5fzoA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C
(Homo
sapiens) 		4 / 8 LYS A2408
GLU A2412
ILE A2409
GLU A2442
 None
 0.83A 2j9dJ-5fzoA:
undetectable
2j9dK-5fzoA:
undetectable
2j9dL-5fzoA:
undetectable		 2j9dJ-5fzoA:
15.36
2j9dK-5fzoA:
15.36
2j9dL-5fzoA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C
(Homo
sapiens) 		4 / 8 LYS A2408
GLU A2412
ILE A2409
GLU A2442
 None
 0.84A 2j9dJ-5fzoA:
undetectable
2j9dK-5fzoA:
undetectable
2j9dL-5fzoA:
undetectable		 2j9dJ-5fzoA:
15.36
2j9dK-5fzoA:
15.36
2j9dL-5fzoA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C
(Homo
sapiens) 		5 / 10 LEU A2335
ILE A2402
ARG A2403
PRO A2191
GLY A2463
 None
 1.47A 3hcpB-5fzoA:
undetectable		 3hcpB-5fzoA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C
(Homo
sapiens) 		5 / 11 GLN A2476
ASN A2470
VAL A2323
PHE A2367
ARG A2379
 None
 1.36A 3n23A-5fzoA:
undetectable		 3n23A-5fzoA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C
(Homo
sapiens) 		5 / 11 GLN A2476
ASN A2470
VAL A2323
PHE A2367
ARG A2379
 None
 1.36A 3n23C-5fzoA:
undetectable		 3n23C-5fzoA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C
(Homo
sapiens) 		3 / 3 VAL A2477
VAL A2197
SER A2284
 None
 0.68A 3n8xB-5fzoA:
undetectable		 3n8xB-5fzoA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C
(Homo
sapiens) 		4 / 8 ILE A2375
ARG A2379
PRO A2191
VAL A2193
 None
 1.19A 4f4dB-5fzoA:
undetectable		 4f4dB-5fzoA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C
(Homo
sapiens) 		4 / 6 PHE A2367
ILE A2451
ARG A2379
VAL A2349
 None
 1.28A 4mk4B-5fzoA:
undetectable		 4mk4B-5fzoA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C
(Homo
sapiens) 		4 / 5 ASN A2470
GLU A2243
TYR A2348
PHE A2242
 None
 1.08A 4twdC-5fzoA:
undetectable
4twdD-5fzoA:
undetectable		 4twdC-5fzoA:
22.22
4twdD-5fzoA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C
(Homo
sapiens) 		4 / 6 ASN A2470
GLU A2243
TYR A2348
PHE A2242
 None
 1.13A 4twdD-5fzoA:
undetectable
4twdE-5fzoA:
undetectable		 4twdD-5fzoA:
22.22
4twdE-5fzoA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C
(Homo
sapiens) 		4 / 6 ASN A2470
GLU A2243
TYR A2348
PHE A2242
 None
 1.17A 4twdG-5fzoA:
undetectable
4twdH-5fzoA:
undetectable		 4twdG-5fzoA:
22.22
4twdH-5fzoA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C
(Homo
sapiens) 		4 / 5 ARG A2403
ILE A2402
GLY A2396
ILE A2424
 None
 0.87A 5dzki-5fzoA:
undetectable
5dzkj-5fzoA:
undetectable
5dzkx-5fzoA:
undetectable		 5dzki-5fzoA:
20.67
5dzkj-5fzoA:
20.67
5dzkx-5fzoA:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3D_A_FCNA205_1
(FOSFOMYCIN
RESISTANCE PROTEIN)		 5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C
(Homo
sapiens) 		5 / 10 HIS A2466
THR A2333
TRP A2391
HIS A2336
GLU A2338
 MN  A3499 (-3.4A)
None
None
MN  A3499 (-3.4A)
MN  A3499 (-2.5A)
 1.21A 5v3dA-5fzoA:
undetectable
5v3dB-5fzoA:
undetectable		 5v3dA-5fzoA:
16.47
5v3dB-5fzoA:
16.47