SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5g06'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 5g06 EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae) 		3 / 3 ALA H 117
VAL H 119
TRP H 124
 None
 0.75A 1av2A-5g06H:
undetectable
1av2B-5g06H:
undetectable		 1av2A-5g06H:
4.71
1av2B-5g06H:
4.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 5g06 EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae) 		3 / 3 TRP H 124
ALA H 117
VAL H 119
 None
 0.76A 1av2C-5g06H:
undetectable
1av2D-5g06H:
undetectable		 1av2C-5g06H:
4.71
1av2D-5g06H:
4.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5g06 EXOSOME COMPLEX
COMPONENT RRP40
(Saccharomyces
cerevisiae) 		4 / 6 HIS G  43
ALA G  55
GLY G  22
TYR G  56
 None
 1.08A 1l5qA-5g06G:
undetectable		 1l5qA-5g06G:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5g06 EXOSOME COMPLEX
COMPONENT RRP40
(Saccharomyces
cerevisiae) 		4 / 6 HIS G  43
ALA G  55
GLY G  22
TYR G  56
 None
 1.08A 1l5qB-5g06G:
undetectable		 1l5qB-5g06G:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5g06 EXOSOME COMPLEX
COMPONENT RRP40
(Saccharomyces
cerevisiae) 		4 / 6 HIS G  43
ALA G  55
GLY G  22
TYR G  56
 None
 1.11A 1l7xA-5g06G:
undetectable		 1l7xA-5g06G:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5g06 EXOSOME COMPLEX
COMPONENT RRP40
(Saccharomyces
cerevisiae) 		4 / 6 HIS G  43
ALA G  55
GLY G  22
TYR G  56
 None
 1.12A 1l7xB-5g06G:
undetectable		 1l7xB-5g06G:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 5g06 EXOSOME COMPLEX
COMPONENT RRP40
(Saccharomyces
cerevisiae) 		5 / 12 VAL G 158
TYR G 208
VAL G 196
LEU G 175
LEU G 178
 None
 1.14A 1s19A-5g06G:
undetectable		 1s19A-5g06G:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5g06 EXOSOME COMPLEX
COMPONENT RRP42
(Saccharomyces
cerevisiae) 		4 / 6 VAL E  92
ILE E 141
ILE E  82
ASP E  79
 None
 0.82A 1uwhA-5g06E:
undetectable		 1uwhA-5g06E:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 5g06 EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae) 		3 / 3 ALA H 117
VAL H 119
TRP H 124
 None
 0.73A 1w5uA-5g06H:
undetectable
1w5uB-5g06H:
undetectable		 1w5uA-5g06H:
4.71
1w5uB-5g06H:
4.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 5g06 EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae) 		3 / 3 TRP H 124
ALA H 117
VAL H 119
 None
 0.71A 1w5uA-5g06H:
undetectable
1w5uB-5g06H:
undetectable		 1w5uA-5g06H:
4.71
1w5uB-5g06H:
4.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5g06 EXOSOME COMPLEX
COMPONENT RRP42
(Saccharomyces
cerevisiae) 		5 / 12 ALA E 209
LEU E 198
LEU E 231
ILE E 215
LEU E 244
 None
 0.91A 2aclA-5g06E:
undetectable
2aclE-5g06E:
undetectable		 2aclA-5g06E:
23.16
2aclE-5g06E:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 5g06 EXOSOME COMPLEX
COMPONENT CSL4
(Saccharomyces
cerevisiae) 		4 / 6 GLU I 222
SER I 207
GLN I 149
ASP I 214
 None
 0.99A 2cl5B-5g06I:
undetectable		 2cl5B-5g06I:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5g06 EXOSOME COMPLEX
COMPONENT SKI6
(Saccharomyces
cerevisiae) 		5 / 12 ASP B 173
GLY B 160
SER B 159
ASN B 141
ILE B 161
 None
 1.13A 2e7fA-5g06B:
undetectable		 2e7fA-5g06B:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 5g06 EXOSOME COMPLEX
COMPONENT SKI6
(Saccharomyces
cerevisiae) 		5 / 12 PHE B 108
VAL B 189
SER B 197
VAL B 224
LEU B 172
 None
 1.31A 2hc4A-5g06B:
undetectable		 2hc4A-5g06B:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 5g06 EXOSOME COMPLEX
COMPONENT RRP4
EXOSOME COMPLEX
COMPONENT SKI6
(Saccharomyces
cerevisiae) 		5 / 12 GLY H 102
ASP B 149
ILE B 148
GLY H  86
ILE H  98
 None
 1.00A 2hs1A-5g06H:
undetectable		 2hs1A-5g06H:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 5g06 EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae) 		3 / 3 ALA H 117
VAL H 119
TRP H 124
 None
 0.78A 2izqA-5g06H:
undetectable
2izqB-5g06H:
undetectable		 2izqA-5g06H:
4.71
2izqB-5g06H:
4.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 5g06 EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae) 		3 / 3 TRP H 124
ALA H 117
VAL H 119
 None
 0.69A 2izqC-5g06H:
undetectable
2izqD-5g06H:
undetectable		 2izqC-5g06H:
4.71
2izqD-5g06H:
4.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 5g06 EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae) 		4 / 4 LEU H 217
THR H 222
ILE H 314
HIS H 213
 None
 1.10A 2jfaB-5g06H:
undetectable		 2jfaB-5g06H:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 5g06 EXOSOME COMPLEX
COMPONENT RRP46
EXOSOME COMPLEX
COMPONENT CSL4
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ARG I 142
GLN D  45
PRO D  43
 None
 1.00A 2qhfA-5g06I:
undetectable		 2qhfA-5g06I:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 5g06 EXOSOME COMPLEX
COMPONENT SKI6
(Saccharomyces
cerevisiae) 		5 / 12 ILE B 126
THR B  51
LEU B 104
GLU B 109
ILE B 158
 None
 1.09A 2vn0A-5g06B:
undetectable		 2vn0A-5g06B:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5g06 EXOSOME COMPLEX
COMPONENT CSL4
(Saccharomyces
cerevisiae) 		3 / 3 PRO I  19
GLY I  22
TYR I  35
 None
 0.47A 2vouA-5g06I:
undetectable		 2vouA-5g06I:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5g06 EXOSOME COMPLEX
COMPONENT CSL4
(Saccharomyces
cerevisiae) 		3 / 3 PRO I  19
GLY I  22
TYR I  35
 None
 0.55A 2vouB-5g06I:
undetectable		 2vouB-5g06I:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5g06 EXOSOME COMPLEX
COMPONENT CSL4
(Saccharomyces
cerevisiae) 		3 / 3 PRO I  19
GLY I  22
TYR I  35
 None
 0.54A 2vouC-5g06I:
undetectable		 2vouC-5g06I:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 5g06 EXOSOME COMPLEX
COMPONENT SKI6
EXOSOME COMPLEX
COMPONENT RRP42
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 GLU B 125
GLN E  85
ARG E  86
 None
 0.92A 2w3bB-5g06B:
undetectable		 2w3bB-5g06B:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 5g06 EXOSOME COMPLEX
COMPONENT SKI6
(Saccharomyces
cerevisiae) 		5 / 12 ILE B 135
SER B 138
ALA B 221
VAL B 224
VAL B 163
 None
 1.20A 2yvlC-5g06B:
undetectable		 2yvlC-5g06B:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 5g06 EXOSOME COMPLEX
COMPONENT CSL4
(Saccharomyces
cerevisiae) 		4 / 6 GLU I 222
SER I 207
GLN I 149
ASP I 214
 None
 1.04A 2zvjA-5g06I:
undetectable		 2zvjA-5g06I:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5g06 EXOSOME COMPLEX
COMPONENT RRP40
(Saccharomyces
cerevisiae) 		4 / 6 HIS G  43
ALA G  55
GLY G  22
TYR G  56
 None
 1.08A 3dd1B-5g06G:
undetectable		 3dd1B-5g06G:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5g06 EXOSOME COMPLEX
COMPONENT RRP40
(Saccharomyces
cerevisiae) 		4 / 6 HIS G  43
ALA G  55
GLY G  22
TYR G  56
 None
 1.08A 3ddwB-5g06G:
undetectable		 3ddwB-5g06G:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 5g06 EXOSOME COMPLEX
COMPONENT RRP40
EXOSOME COMPLEX
COMPONENT RRP46
(Saccharomyces
cerevisiae) 		5 / 10 GLY D 124
ASP D 122
ILE D 213
GLY G  40
ILE G  57
 None
 1.04A 3el9B-5g06D:
undetectable		 3el9B-5g06D:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5g06 EXOSOME COMPLEX
COMPONENT RRP42
(Saccharomyces
cerevisiae) 		4 / 8 VAL E 102
ILE E  95
VAL E  80
VAL E 128
 None
 0.78A 3fi0B-5g06E:
undetectable		 3fi0B-5g06E:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5g06 EXOSOME COMPLEX
COMPONENT RRP42
(Saccharomyces
cerevisiae) 		4 / 8 VAL E 102
ILE E  95
VAL E  80
VAL E 128
 None
 0.74A 3fi0G-5g06E:
undetectable		 3fi0G-5g06E:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5g06 EXOSOME COMPLEX
COMPONENT RRP42
(Saccharomyces
cerevisiae) 		4 / 8 VAL E 102
ILE E  95
VAL E  80
VAL E 128
 None
 0.77A 3fi0Q-5g06E:
undetectable		 3fi0Q-5g06E:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 5g06 EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae) 		4 / 7 ASN H 142
TYR H 281
HIS H 111
ALA H 171
 None
 1.08A 3frqB-5g06H:
undetectable		 3frqB-5g06H:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5g06 EXOSOME COMPLEX
COMPONENT SKI6
(Saccharomyces
cerevisiae) 		5 / 12 ASP B 173
GLY B 160
SER B 159
ASN B 141
ILE B 161
 None
 1.15A 3k13A-5g06B:
undetectable		 3k13A-5g06B:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5g06 EXOSOME COMPLEX
COMPONENT SKI6
(Saccharomyces
cerevisiae) 		5 / 12 ASP B 173
GLY B 160
SER B 159
ASN B 141
ILE B 161
 None
 1.15A 3k13B-5g06B:
undetectable		 3k13B-5g06B:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5g06 EXOSOME COMPLEX
COMPONENT SKI6
(Saccharomyces
cerevisiae) 		5 / 12 ASP B 173
GLY B 160
SER B 159
ASN B 141
ILE B 161
 None
 1.14A 3k13C-5g06B:
undetectable		 3k13C-5g06B:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 5g06 EXOSOME COMPLEX
COMPONENT RRP42
(Saccharomyces
cerevisiae) 		5 / 10 THR E  94
GLU E  93
LEU E  98
LEU E  99
ILE E 138
 None
 1.03A 3kvrA-5g06E:
undetectable		 3kvrA-5g06E:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 5g06 EXOSOME COMPLEX
COMPONENT RRP42
(Saccharomyces
cerevisiae) 		5 / 10 THR E  94
GLU E  93
LEU E  98
LEU E  99
ILE E 138
 None
 1.09A 3kvrB-5g06E:
undetectable		 3kvrB-5g06E:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 5g06 EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae) 		3 / 3 TRP H 124
ALA H 117
VAL H 119
 None
 0.75A 3l8lA-5g06H:
undetectable
3l8lB-5g06H:
undetectable		 3l8lA-5g06H:
4.71
3l8lB-5g06H:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 5g06 EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae) 		3 / 3 TRP H 124
ALA H 117
VAL H 119
 None
 0.71A 3l8lC-5g06H:
undetectable
3l8lD-5g06H:
undetectable		 3l8lC-5g06H:
4.71
3l8lD-5g06H:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 5g06 EXOSOME COMPLEX
COMPONENT RRP4
EXOSOME COMPLEX
COMPONENT RRP42
EXOSOME COMPLEX
COMPONENT SKI6
(Saccharomyces
cerevisiae) 		3 / 3 HIS B 127
PHE E  40
PHE H  14
 None
 0.79A 3lk0D-5g06B:
undetectable		 3lk0D-5g06B:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 5g06 EXOSOME COMPLEX
COMPONENT RRP42
(Saccharomyces
cerevisiae) 		5 / 9 THR E  94
GLU E  93
LEU E  98
LEU E  99
ILE E 138
 None
 1.04A 3nbqA-5g06E:
undetectable		 3nbqA-5g06E:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 5g06 EXOSOME COMPLEX
COMPONENT CSL4
(Saccharomyces
cerevisiae) 		4 / 6 ILE I 221
ASN I 261
PRO I 226
LEU I 146
 None
 1.23A 3oi8A-5g06I:
undetectable		 3oi8A-5g06I:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 5g06 EXOSOME COMPLEX
COMPONENT SKI6
EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 TYR B 157
LEU B 232
ALA B 236
SER H  52
 None
 0.90A 3rodA-5g06B:
undetectable		 3rodA-5g06B:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 5g06 EXOSOME COMPLEX
COMPONENT RRP42
(Saccharomyces
cerevisiae) 		5 / 9 LEU E  76
LEU E 149
ILE E 141
ILE E  95
VAL E  78
 None
 1.26A 3tmzA-5g06E:
undetectable		 3tmzA-5g06E:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 5g06 EXOSOME COMPLEX
COMPONENT RRP4
EXOSOME COMPLEX
COMPONENT RRP42
(Saccharomyces
cerevisiae) 		5 / 9 ILE E  50
SER H   2
ILE H   5
ILE E  34
THR E  38
 None
 1.21A 3tq8A-5g06E:
undetectable		 3tq8A-5g06E:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 5g06 EXOSOME COMPLEX
COMPONENT CSL4
(Saccharomyces
cerevisiae) 		4 / 5 LEU I 156
ALA I 193
PHE I 201
ASN I 126
 None
 1.41A 3uq6A-5g06I:
undetectable		 3uq6A-5g06I:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 5g06 EXOSOME COMPLEX
COMPONENT SKI6
EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 10 GLY H  58
TYR H  81
ASP B 156
GLY B 191
SER B 193
 None
 1.27A 4bwlC-5g06H:
undetectable		 4bwlC-5g06H:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5g06 EXOSOME COMPLEX
COMPONENT SKI6
(Saccharomyces
cerevisiae) 		3 / 3 TYR B  41
MET B  42
ILE B 140
 None
 0.76A 4c8bB-5g06B:
undetectable		 4c8bB-5g06B:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5g06 EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae) 		4 / 8 ASN H 228
GLY H 226
VAL H 112
HIS H 111
 None
 0.78A 4fglD-5g06H:
undetectable		 4fglD-5g06H:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 5g06 EXOSOME COMPLEX
COMPONENT RRP42
(Saccharomyces
cerevisiae) 		5 / 12 GLU E 205
MET E 197
ARG E  26
ILE E 214
ILE E 215
 None
 1.24A 4j24C-5g06E:
undetectable		 4j24C-5g06E:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 5g06 EXOSOME COMPLEX
COMPONENT SKI6
(Saccharomyces
cerevisiae) 		3 / 3 ILE B 161
MET B 228
ARG B 225
 None
 0.91A 4lnwA-5g06B:
undetectable		 4lnwA-5g06B:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 5g06 EXOSOME COMPLEX
COMPONENT SKI6
(Saccharomyces
cerevisiae) 		3 / 3 ILE B 161
MET B 228
ARG B 225
 None
 0.92A 4lnxA-5g06B:
undetectable		 4lnxA-5g06B:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5g06 EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae) 		4 / 5 GLN H 201
THR H 214
LEU H 194
LEU H 168
 None
 1.00A 4lvcB-5g06H:
undetectable		 4lvcB-5g06H:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5g06 EXOSOME COMPLEX
COMPONENT RRP42
EXOSOME COMPLEX
COMPONENT SKI6
(Saccharomyces
cerevisiae) 		3 / 3 LEU B  61
ARG B  60
MET E   1
 None
 0.84A 4m11C-5g06B:
undetectable		 4m11C-5g06B:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5g06 EXOSOME COMPLEX
COMPONENT RRP4
EXOSOME COMPLEX
COMPONENT RRP42
(Saccharomyces
cerevisiae) 		5 / 11 ILE E  50
SER H   2
ILE H   5
ILE E  34
THR E  38
 None
 1.23A 4p68A-5g06E:
undetectable		 4p68A-5g06E:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 5g06 EXOSOME COMPLEX
COMPONENT RRP42
(Saccharomyces
cerevisiae) 		5 / 11 LEU E 103
LEU E 149
ASN E 150
VAL E  60
ILE E  62
 None
 1.12A 4x20D-5g06E:
undetectable		 4x20D-5g06E:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 5g06 EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae) 		4 / 6 ALA H 301
LYS H 305
LEU H 233
MET H 198
 None
 1.19A 4xoyA-5g06H:
undetectable		 4xoyA-5g06H:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 5g06 EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae) 		4 / 6 ALA H 301
LYS H 305
LEU H 233
MET H 198
 None
 1.17A 4xp3A-5g06H:
undetectable		 4xp3A-5g06H:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 5g06 EXOSOME COMPLEX
COMPONENT SKI6
EXOSOME COMPLEX
COMPONENT RRP42
EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 ILE B  50
PHE H  14
ILE E 131
GLU E  57
 None
 1.39A 4zzcA-5g06B:
undetectable
4zzcB-5g06B:
undetectable		 4zzcA-5g06B:
23.26
4zzcB-5g06B:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 5g06 EXOSOME COMPLEX
COMPONENT SKI6
EXOSOME COMPLEX
COMPONENT RRP42
EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 ILE B  50
PHE H  14
ILE E 131
GLU E  57
 None
 1.37A 4zzcB-5g06B:
undetectable
4zzcC-5g06B:
undetectable		 4zzcB-5g06B:
23.26
4zzcC-5g06B:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5g06 EXOSOME COMPLEX
COMPONENT SKI6
(Saccharomyces
cerevisiae) 		4 / 5 ALA B 215
HIS B 222
ALA B 219
GLU B 194
 None
 1.29A 5a06C-5g06B:
undetectable
5a06D-5g06B:
undetectable		 5a06C-5g06B:
20.83
5a06D-5g06B:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 5g06 EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae) 		3 / 3 VAL H 224
THR H 222
ARG H 234
 None
 0.70A 5b2sB-5g06H:
3.2		 5b2sB-5g06H:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 5g06 EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae) 		3 / 3 VAL H 224
THR H 222
ARG H 234
 None
 0.69A 5b2tB-5g06H:
3.2		 5b2tB-5g06H:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5g06 EXOSOME COMPLEX
COMPONENT CSL4
(Saccharomyces
cerevisiae) 		4 / 5 GLU I 222
SER I 207
GLN I 149
ASP I 214
 None
 1.00A 5fhrB-5g06I:
undetectable		 5fhrB-5g06I:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 5g06 EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae) 		4 / 6 HIS H 111
VAL H 113
LEU H 225
THR H 214
 None
 1.02A 5ogjA-5g06H:
undetectable		 5ogjA-5g06H:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_B_ACTB305_0
(CARBONIC ANHYDRASE
13)		 5g06 EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae) 		4 / 6 HIS H 111
VAL H 113
LEU H 225
THR H 214
 None
 1.03A 5ogjB-5g06H:
undetectable		 5ogjB-5g06H:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 5g06 EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae) 		4 / 5 HIS H 111
VAL H 113
LEU H 225
THR H 214
 None
 1.03A 5ohhA-5g06H:
undetectable		 5ohhA-5g06H:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_B_ACTB311_0
(CARBONIC ANHYDRASE
13)		 5g06 EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae) 		4 / 6 HIS H 111
VAL H 113
LEU H 225
THR H 214
 None
 1.03A 5ohhB-5g06H:
undetectable		 5ohhB-5g06H:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 5g06 EXOSOME COMPLEX
COMPONENT RRP42
(Saccharomyces
cerevisiae) 		3 / 3 GLU E  72
HIS E  70
VAL E  71
 None
 0.90A 5trqB-5g06E:
undetectable		 5trqB-5g06E:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 5g06 EXOSOME COMPLEX
COMPONENT RRP42
(Saccharomyces
cerevisiae) 		4 / 7 VAL E 130
ARG E  49
GLU E  57
LEU E  41
 None
 1.20A 5umwB-5g06E:
undetectable
5umwE-5g06E:
undetectable		 5umwB-5g06E:
13.26
5umwE-5g06E:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5g06 EXOSOME COMPLEX
COMPONENT RRP42
(Saccharomyces
cerevisiae) 		4 / 8 PHE E 172
SER E  64
MET E 177
LEU E 116
 None
 1.09A 5y2tB-5g06E:
undetectable		 5y2tB-5g06E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5g06 EXOSOME COMPLEX
COMPONENT RRP40
(Saccharomyces
cerevisiae) 		4 / 6 PHE G 231
VAL G 196
LEU G 175
LEU G 178
 None
 0.72A 6e43A-5g06G:
undetectable		 6e43A-5g06G:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5g06 EXOSOME COMPLEX
COMPONENT RRP40
(Saccharomyces
cerevisiae) 		4 / 6 PHE G 231
VAL G 196
LEU G 175
LEU G 178
 None
 0.77A 6e43B-5g06G:
undetectable		 6e43B-5g06G:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5g06 EXOSOME COMPLEX
COMPONENT RRP40
(Saccharomyces
cerevisiae) 		4 / 6 PHE G 231
VAL G 196
LEU G 175
LEU G 178
 None
 0.69A 6e43C-5g06G:
undetectable		 6e43C-5g06G:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5g06 EXOSOME COMPLEX
COMPONENT RRP40
(Saccharomyces
cerevisiae) 		4 / 6 PHE G 231
VAL G 196
LEU G 175
LEU G 178
 None
 0.86A 6e43D-5g06G:
undetectable		 6e43D-5g06G:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 5g06 EXOSOME COMPLEX
COMPONENT SKI6
(Saccharomyces
cerevisiae) 		4 / 8 VAL B 189
GLN B  44
ASN B 141
ILE B 140
 None
 1.09A 6hzpA-5g06B:
undetectable		 6hzpA-5g06B:
19.12