SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5g0a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		5 / 8 THR A 273
GLY A 283
GLY A 385
LEU A 387
GLY A 383
 None
 1.13A 1d0vA-5g0aA:
undetectable		 1d0vA-5g0aA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		4 / 8 PHE A 282
GLY A 276
ARG A 277
LEU A 447
 None
 0.85A 1gsfC-5g0aA:
undetectable		 1gsfC-5g0aA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		5 / 11 SER A 446
GLY A  65
PHE A 353
GLY A  41
ASP A  42
 None
 1.43A 1ho5A-5g0aA:
undetectable		 1ho5A-5g0aA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_B_ADNB2604_1
(5'-NUCLEOTIDASE)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		5 / 10 SER A 446
GLY A  65
PHE A 353
GLY A  41
ASP A  42
 None
 1.46A 1ho5B-5g0aA:
undetectable		 1ho5B-5g0aA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		5 / 8 THR A 273
GLY A 283
GLY A 385
LEU A 387
GLY A 383
 None
 1.14A 1jhaA-5g0aA:
undetectable		 1jhaA-5g0aA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		5 / 9 THR A 273
GLY A 283
GLY A 385
LEU A 387
GLY A 383
 None
 1.13A 1jhoA-5g0aA:
undetectable		 1jhoA-5g0aA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		5 / 9 THR A 273
GLY A 283
GLY A 385
LEU A 387
GLY A 383
 None
 1.13A 1jhrA-5g0aA:
undetectable		 1jhrA-5g0aA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		5 / 9 THR A 273
GLY A 283
GLY A 385
LEU A 387
GLY A 383
 None
 1.11A 1jhyA-5g0aA:
undetectable		 1jhyA-5g0aA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		5 / 9 THR A 273
GLY A 283
GLY A 385
LEU A 387
GLY A 383
 None
 1.14A 1l4nA-5g0aA:
undetectable		 1l4nA-5g0aA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		5 / 9 THR A 273
GLY A 283
GLY A 385
LEU A 387
GLY A 383
 None
 1.12A 1l5kA-5g0aA:
undetectable		 1l5kA-5g0aA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		5 / 9 THR A 273
GLY A 283
GLY A 385
LEU A 387
GLY A 383
 None
 1.15A 1l5lA-5g0aA:
undetectable		 1l5lA-5g0aA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		5 / 9 THR A 273
GLY A 283
GLY A 385
LEU A 387
GLY A 383
 None
 1.13A 1l5mA-5g0aA:
undetectable		 1l5mA-5g0aA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		5 / 8 THR A 440
ASP A 391
ASN A 380
MET A 441
LEU A 461
 None
 1.43A 1lhvA-5g0aA:
undetectable		 1lhvA-5g0aA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		4 / 8 ARG A 277
ASN A  63
GLN A  66
ASP A  54
 None
 1.34A 1p6kA-5g0aA:
undetectable		 1p6kA-5g0aA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		4 / 8 ARG A 277
ASN A  63
GLN A  66
ASP A  54
 None
 1.33A 1zzuA-5g0aA:
undetectable		 1zzuA-5g0aA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		4 / 8 ARG A 277
ASN A  63
GLN A  66
ASP A  54
 None
 1.31A 1zzuB-5g0aA:
undetectable		 1zzuB-5g0aA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_C_SAMC803_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		5 / 11 GLY A  65
LEU A  64
SER A 360
ASN A  57
PHE A  55
 None
 1.41A 2h21C-5g0aA:
undetectable		 2h21C-5g0aA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		4 / 7 LEU A 345
PHE A 275
ILE A 101
PHE A 117
 None
 0.92A 2opxA-5g0aA:
undetectable		 2opxA-5g0aA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		4 / 7 GLY A 308
PHE A 275
ILE A 101
PHE A 282
 None
 0.96A 2qmzA-5g0aA:
undetectable
2qmzB-5g0aA:
undetectable		 2qmzA-5g0aA:
19.34
2qmzB-5g0aA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		4 / 7 LEU A  44
LEU A 427
ILE A 433
GLN A  58
 None
 1.06A 2qqcA-5g0aA:
undetectable
2qqcF-5g0aA:
undetectable		 2qqcA-5g0aA:
8.97
2qqcF-5g0aA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		4 / 7 LEU A  44
LEU A 427
ILE A 433
GLN A  58
 None
 1.02A 2qqcG-5g0aA:
undetectable
2qqcJ-5g0aA:
undetectable		 2qqcG-5g0aA:
8.97
2qqcJ-5g0aA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		5 / 11 ILE A 235
THR A 259
PRO A 253
VAL A 234
THR A 295
 None
 1.26A 2w3aA-5g0aA:
undetectable		 2w3aA-5g0aA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		4 / 6 VAL A 312
TRP A 111
ARG A 256
THR A 236
 None
None
PEG  A1477 (-4.4A)
None
 1.19A 2x2iA-5g0aA:
undetectable		 2x2iA-5g0aA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B500_1
(ORF12)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		5 / 9 ILE A 443
LEU A 447
ARG A 277
GLY A 385
ALA A 357
 None
 1.42A 2xf3B-5g0aA:
undetectable		 2xf3B-5g0aA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		4 / 7 SER A 239
TYR A 384
ILE A 389
TRP A 388
 None
 1.05A 3bu1A-5g0aA:
undetectable		 3bu1A-5g0aA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		5 / 12 ARG A 116
PHE A  84
GLY A 333
ALA A 332
SER A 119
 None
 1.23A 3n8xA-5g0aA:
undetectable		 3n8xA-5g0aA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		4 / 7 GLY A  65
VAL A  62
ASN A 448
GLY A 444
 None
 0.83A 4forA-5g0aA:
undetectable		 4forA-5g0aA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		5 / 9 THR A 273
GLY A 283
GLY A 385
LEU A 387
GLY A 383
 None
 1.15A 4kqiA-5g0aA:
undetectable		 4kqiA-5g0aA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		5 / 9 GLY A 154
ALA A 155
THR A 159
ILE A 267
VAL A 189
 None
 1.00A 4r21B-5g0aA:
undetectable		 4r21B-5g0aA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		5 / 10 ALA A  98
ILE A 101
GLY A 308
PHE A 117
VAL A 341
 None
 0.68A 5i6xA-5g0aA:
undetectable		 5i6xA-5g0aA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		4 / 8 SER A 302
ASN A  63
LEU A  64
VAL A 354
 None
 0.99A 5m8rB-5g0aA:
undetectable		 5m8rB-5g0aA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		4 / 8 SER A 302
ASN A  63
LEU A  64
VAL A 354
 None
 0.95A 5m8rD-5g0aA:
undetectable		 5m8rD-5g0aA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		4 / 7 ILE A 443
PHE A  55
LYS A 367
SER A 450
 None
 1.30A 5nr3A-5g0aA:
undetectable		 5nr3A-5g0aA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		4 / 7 ARG A 256
TYR A 135
GLU A 315
SER A 313
 PEG  A1477 (-4.4A)
PGE  A1479 (-4.4A)
PGE  A1479 (-3.2A)
PEG  A1477 ( 4.4A)
 1.10A 5umwA-5g0aA:
undetectable
5umwF-5g0aA:
undetectable		 5umwA-5g0aA:
10.13
5umwF-5g0aA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		5 / 9 GLY A 279
GLY A 385
LEU A 386
GLU A 362
SER A 360
 None
 1.14A 5vw4A-5g0aA:
undetectable		 5vw4A-5g0aA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		5 / 12 GLU A 237
TRP A 266
PRO A 112
VAL A 189
GLY A 154
 PLP  A1298 (-3.9A)
None
None
None
None
 1.21A 6gngA-5g0aA:
undetectable		 6gngA-5g0aA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 5g0a TRANSAMINASE
(Bacillus
megaterium) 		4 / 6 ARG A 116
SER A 327
THR A 152
ALA A 124
 None
 1.12A 6ma6A-5g0aA:
undetectable		 6ma6A-5g0aA:
9.79