SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5g1q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 5g1q CLP PROTEASE
PROTEOLYTIC SUBUNIT
P
(Francisella
tularensis) 		5 / 9 ILE A 123
ILE A  67
GLY A  97
ALA A  99
THR A  93
 None
 1.36A 2dtjA-5g1qA:
undetectable
2dtjB-5g1qA:
undetectable		 2dtjA-5g1qA:
20.30
2dtjB-5g1qA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 5g1q CLP PROTEASE
PROTEOLYTIC SUBUNIT
P
(Francisella
tularensis) 		5 / 9 VAL A  39
GLY A  71
LEU A 105
SER A 101
LEU A 153
 None
 1.30A 2j2pB-5g1qA:
undetectable
2j2pC-5g1qA:
undetectable		 2j2pB-5g1qA:
22.41
2j2pC-5g1qA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 5g1q CLP PROTEASE
PROTEOLYTIC SUBUNIT
P
(Francisella
tularensis) 		3 / 3 ASN A 145
LEU A 147
HIS A 142
 None
 0.81A 2q6fB-5g1qA:
undetectable		 2q6fB-5g1qA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5g1q CLP PROTEASE
PROTEOLYTIC SUBUNIT
P
(Francisella
tularensis) 		3 / 3 ARG A  26
LYS A  29
ARG A  19
 None
 1.46A 3w1wA-5g1qA:
undetectable
3w1wB-5g1qA:
undetectable		 3w1wA-5g1qA:
19.65
3w1wB-5g1qA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5g1q CLP PROTEASE
PROTEOLYTIC SUBUNIT
P
(Francisella
tularensis) 		3 / 3 ARG A  19
ARG A  26
LYS A  29
 None
 1.42A 3w1wA-5g1qA:
undetectable
3w1wB-5g1qA:
undetectable		 3w1wA-5g1qA:
19.65
3w1wB-5g1qA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5g1q CLP PROTEASE
PROTEOLYTIC SUBUNIT
P
(Francisella
tularensis) 		5 / 12 ASP A  82
LEU A 107
LEU A 188
THR A 161
ARG A 152
 None
 1.35A 5hnxB-5g1qA:
undetectable		 5hnxB-5g1qA:
19.20