SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5g2c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5g2c CHLORIDE PUMPING
RHODOPSIN
(Nonlabens
marinus) 		5 / 12 CYH A 105
PRO A 104
ILE A 103
SER A 234
TYR A 238
 None
None
None
RET  A1273 (-3.2A)
None
 1.07A 1z9hD-5g2cA:
undetectable		 1z9hD-5g2cA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5g2c CHLORIDE PUMPING
RHODOPSIN
(Nonlabens
marinus) 		5 / 12 GLY A 139
GLY A 142
ILE A 137
ILE A 136
SER A 160
 RET  A1273 ( 3.7A)
None
OLA  A1276 ( 4.4A)
None
RET  A1273 (-3.3A)
 1.07A 4iv0B-5g2cA:
undetectable		 4iv0B-5g2cA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5g2c CHLORIDE PUMPING
RHODOPSIN
(Nonlabens
marinus) 		5 / 12 GLY A 139
GLY A 142
ILE A 137
ILE A 136
SER A 160
 RET  A1273 ( 3.7A)
None
OLA  A1276 ( 4.4A)
None
RET  A1273 (-3.3A)
 1.07A 4mwzA-5g2cA:
undetectable		 4mwzA-5g2cA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXF_A_BEZA601_0
(EUGENOL OXIDASE)		 5g2c CHLORIDE PUMPING
RHODOPSIN
(Nonlabens
marinus) 		5 / 9 VAL A 193
TYR A 238
GLN A 109
ILE A 242
VAL A 113
 None
 1.45A 5fxfA-5g2cA:
undetectable		 5fxfA-5g2cA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXF_B_BEZB601_0
(EUGENOL OXIDASE)		 5g2c CHLORIDE PUMPING
RHODOPSIN
(Nonlabens
marinus) 		5 / 10 VAL A 193
TYR A 238
GLN A 109
ILE A 242
VAL A 113
 None
 1.44A 5fxfB-5g2cA:
0.3		 5fxfB-5g2cA:
20.69