SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5g2x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 5g2x GROUP II
INTRON-ENCODED
PROTEIN LTRA
(Lactococcus
lactis) 		5 / 10 ILE C 439
ARG C 537
TYR C 443
ILE C 398
ILE C 394
 None
 1.30A 2dm6A-5g2xC:
undetectable
2dm6B-5g2xC:
undetectable		 2dm6A-5g2xC:
19.62
2dm6B-5g2xC:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5g2x GROUP II
INTRON-ENCODED
PROTEIN LTRA
(Lactococcus
lactis) 		4 / 8 THR C 466
SER C 423
ARG C 422
ASN C 433
 None
 1.12A 3kp2A-5g2xC:
undetectable
3kp2B-5g2xC:
undetectable		 3kp2A-5g2xC:
14.05
3kp2B-5g2xC:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 5g2x GROUP II
INTRON-ENCODED
PROTEIN LTRA
(Lactococcus
lactis) 		5 / 12 GLY C  53
ALA C  59
ASP C 107
ASP C  57
GLN C 111
 None
 1.27A 3nmuA-5g2xC:
undetectable
3nmuF-5g2xC:
undetectable		 3nmuA-5g2xC:
22.31
3nmuF-5g2xC:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 5g2x GROUP II
INTRON-ENCODED
PROTEIN LTRA
(Lactococcus
lactis) 		3 / 3 SER C 480
PHE C 482
LYS C 483
 None
C  A 153 ( 3.7A)
None
 0.44A 3u88A-5g2xC:
0.0		 3u88A-5g2xC:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5g2x GROUP II
INTRON-ENCODED
PROTEIN LTRA
(Lactococcus
lactis) 		5 / 12 GLY C  53
ALA C  59
ASP C 107
ASP C  57
GLN C 111
 None
 1.28A 4df3A-5g2xC:
undetectable		 4df3A-5g2xC:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ4_B_IMNB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5g2x GROUP II
INTRON-ENCODED
PROTEIN LTRA
(Lactococcus
lactis) 		5 / 10 HIS C 131
VAL C 304
ILE C 311
TYR C 442
LEU C 357
 None
 1.33A 4jq4B-5g2xC:
undetectable		 4jq4B-5g2xC:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5g2x GROUP II
INTRON-ENCODED
PROTEIN LTRA
(Lactococcus
lactis) 		4 / 8 GLY C 210
GLY C 214
LEU C 217
LEU C 221
 None
 0.84A 4mwzB-5g2xC:
undetectable		 4mwzB-5g2xC:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 5g2x GROUP II
INTRON-ENCODED
PROTEIN LTRA
(Lactococcus
lactis) 		4 / 8 ARG C 115
GLU C 112
GLY C  53
ASP C  57
 None
 1.16A 5kf8A-5g2xC:
undetectable		 5kf8A-5g2xC:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA810_1
(CATALASE-PEROXIDASE)		 5g2x GROUP II
INTRON-ENCODED
PROTEIN LTRA
(Lactococcus
lactis) 		4 / 6 ARG C 378
LEU C 452
PRO C 389
SER C 447
 A  B   2 ( 3.5A)
None
None
None
 1.10A 5syjA-5g2xC:
undetectable		 5syjA-5g2xC:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)		 5g2x GROUP II
INTRON-ENCODED
PROTEIN LTRA
(Lactococcus
lactis) 		4 / 6 ARG C 378
LEU C 452
PRO C 389
SER C 447
 A  B   2 ( 3.5A)
None
None
None
 1.05A 5syjB-5g2xC:
undetectable		 5syjB-5g2xC:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 5g2x GROUP II
INTRON-ENCODED
PROTEIN LTRA
(Lactococcus
lactis) 		4 / 8 LEU C 194
ILE C 224
ALA C 113
LEU C   8
 None
 0.72A 5y7pC-5g2xC:
undetectable		 5y7pC-5g2xC:
19.90