SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5g39'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 5g39 PHOTOSYSTEM II
MANGANESE-STABILIZIN
G POLYPEPTIDE
(Thermosynechococ
cus
elongatus) 		5 / 9 ILE A 129
PHE A 135
THR A 122
VAL A 126
LEU A  78
 None
 1.14A 2m9qA-5g39A:
0.7		 2m9qA-5g39A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5g39 PHOTOSYSTEM II
MANGANESE-STABILIZIN
G POLYPEPTIDE
(Thermosynechococ
cus
elongatus) 		5 / 11 ALA A 120
LEU A 150
LEU A  43
ILE A  40
ILE A 162
 None
 1.01A 2w9sA-5g39A:
undetectable		 2w9sA-5g39A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5g39 PHOTOSYSTEM II
MANGANESE-STABILIZIN
G POLYPEPTIDE
(Thermosynechococ
cus
elongatus) 		5 / 11 ALA A 120
LEU A 150
LEU A  43
ILE A  40
ILE A 162
 None
 1.06A 2w9sB-5g39A:
undetectable		 2w9sB-5g39A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 5g39 PHOTOSYSTEM II
MANGANESE-STABILIZIN
G POLYPEPTIDE
(Thermosynechococ
cus
elongatus) 		5 / 9 THR A 133
SER A 168
LEU A 118
ILE A  74
ILE A 129
 None
 1.23A 3cv9A-5g39A:
undetectable		 3cv9A-5g39A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)		 5g39 PHOTOSYSTEM II
MANGANESE-STABILIZIN
G POLYPEPTIDE
(Thermosynechococ
cus
elongatus) 		5 / 11 PHE A 113
SER A 172
LEU A 118
ILE A  74
ASP A  95
 None
 1.44A 3ko0A-5g39A:
undetectable
3ko0B-5g39A:
undetectable
3ko0C-5g39A:
undetectable
3ko0D-5g39A:
undetectable		 3ko0A-5g39A:
20.48
3ko0B-5g39A:
20.48
3ko0C-5g39A:
20.48
3ko0D-5g39A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 5g39 PHOTOSYSTEM II
MANGANESE-STABILIZIN
G POLYPEPTIDE
(Thermosynechococ
cus
elongatus) 		4 / 8 PHE A 183
ILE A  40
PHE A 135
VAL A 115
 None
 0.91A 3me6B-5g39A:
undetectable		 3me6B-5g39A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 5g39 PHOTOSYSTEM II
MANGANESE-STABILIZIN
G POLYPEPTIDE
(Thermosynechococ
cus
elongatus) 		5 / 11 PHE A 183
LEU A 150
PHE A 135
LEU A  43
ILE A  40
 None
 1.27A 3o94A-5g39A:
undetectable		 3o94A-5g39A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 5g39 PHOTOSYSTEM II
MANGANESE-STABILIZIN
G POLYPEPTIDE
(Thermosynechococ
cus
elongatus) 		5 / 11 PHE A 183
LEU A 150
PHE A 135
LEU A  43
ILE A  40
 None
 1.31A 3o94B-5g39A:
undetectable		 3o94B-5g39A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 5g39 PHOTOSYSTEM II
MANGANESE-STABILIZIN
G POLYPEPTIDE
(Thermosynechococ
cus
elongatus) 		5 / 11 PHE A 183
LEU A 150
PHE A 135
LEU A  43
ILE A  40
 None
 1.30A 3o94C-5g39A:
undetectable		 3o94C-5g39A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 5g39 PHOTOSYSTEM II
MANGANESE-STABILIZIN
G POLYPEPTIDE
(Thermosynechococ
cus
elongatus) 		5 / 11 PHE A 183
LEU A 150
PHE A 135
LEU A  43
ILE A  40
 None
 1.29A 3o94D-5g39A:
undetectable		 3o94D-5g39A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 5g39 PHOTOSYSTEM II
MANGANESE-STABILIZIN
G POLYPEPTIDE
(Thermosynechococ
cus
elongatus) 		3 / 3 GLU A  90
PHE A  88
GLN A  75
 None
 1.00A 3r55A-5g39A:
undetectable		 3r55A-5g39A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 5g39 PHOTOSYSTEM II
MANGANESE-STABILIZIN
G POLYPEPTIDE
(Thermosynechococ
cus
elongatus) 		4 / 6 GLN A  97
PHE A  50
PRO A  47
LEU A  63
 None
 1.25A 3tgvD-5g39A:
undetectable		 3tgvD-5g39A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 5g39 PHOTOSYSTEM II
MANGANESE-STABILIZIN
G POLYPEPTIDE
(Thermosynechococ
cus
elongatus) 		4 / 7 TYR A  30
ILE A 187
THR A 130
THR A 131
 None
 0.94A 3tneB-5g39A:
undetectable		 3tneB-5g39A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 5g39 PHOTOSYSTEM II
MANGANESE-STABILIZIN
G POLYPEPTIDE
(Thermosynechococ
cus
elongatus) 		5 / 11 LEU A  45
LEU A  71
ILE A  74
LEU A 118
ILE A 179
 None
 1.10A 4dm8A-5g39A:
undetectable		 4dm8A-5g39A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5g39 PHOTOSYSTEM II
MANGANESE-STABILIZIN
G POLYPEPTIDE
(Thermosynechococ
cus
elongatus) 		4 / 6 GLN A  97
PHE A 113
PHE A  50
LEU A  63
 None
 1.11A 5b1bC-5g39A:
undetectable
5b1bJ-5g39A:
undetectable		 5b1bC-5g39A:
23.68
5b1bJ-5g39A:
20.93