SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5g3z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 5g3z ADENYLATE KINSE
(synthetic
construct) 		4 / 4 GLY A  32
ASP A  84
GLY A   7
THR A  89
 AP5  A1217 (-3.6A)
MG  A1218 ( 4.4A)
None
None
 0.91A 1hxbB-5g3zA:
undetectable		 1hxbB-5g3zA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 5g3z ADENYLATE KINSE
(synthetic
construct) 		5 / 11 GLU A  18
THR A  15
THR A 136
ARG A  71
GLY A  32
 None
AP5  A1217 (-3.6A)
AP5  A1217 (-3.1A)
None
AP5  A1217 (-3.6A)
 1.39A 3ag1A-5g3zA:
undetectable
3ag1B-5g3zA:
undetectable
3ag1T-5g3zA:
undetectable		 3ag1A-5g3zA:
15.80
3ag1B-5g3zA:
23.05
3ag1T-5g3zA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 5g3z ADENYLATE KINSE
(synthetic
construct) 		5 / 11 ARG A  71
GLY A  32
GLU A  18
THR A  15
THR A 136
 None
AP5  A1217 (-3.6A)
None
AP5  A1217 (-3.6A)
AP5  A1217 (-3.1A)
 1.34A 3ag1G-5g3zA:
undetectable
3ag1N-5g3zA:
undetectable
3ag1O-5g3zA:
undetectable		 3ag1G-5g3zA:
14.29
3ag1N-5g3zA:
15.80
3ag1O-5g3zA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 5g3z ADENYLATE KINSE
(synthetic
construct) 		4 / 4 GLY A  32
ASP A  84
GLY A   7
THR A  89
 AP5  A1217 (-3.6A)
MG  A1218 ( 4.4A)
None
None
 0.90A 3k4vC-5g3zA:
undetectable		 3k4vC-5g3zA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 5g3z ADENYLATE KINSE
(synthetic
construct) 		4 / 5 LEU A 107
ALA A  93
PHE A 185
ASN A  98
 None
 1.48A 3uq6A-5g3zA:
2.2		 3uq6A-5g3zA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 5g3z ADENYLATE KINSE
(synthetic
construct) 		5 / 11 ASP A  33
GLY A  14
SER A  30
GLY A  85
ASP A 163
 None
AP5  A1217 (-3.6A)
AP5  A1217 ( 4.8A)
AP5  A1217 (-4.3A)
None
 1.17A 4mm9A-5g3zA:
undetectable		 4mm9A-5g3zA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 5g3z ADENYLATE KINSE
(synthetic
construct) 		4 / 7 THR A 136
ARG A 123
GLY A  12
GLY A  14
 AP5  A1217 (-3.1A)
AP5  A1217 (-3.7A)
AP5  A1217 (-3.1A)
AP5  A1217 (-3.6A)
 0.90A 4rdxA-5g3zA:
2.1		 4rdxA-5g3zA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5g3z ADENYLATE KINSE
(synthetic
construct) 		4 / 4 GLY A  85
VAL A   4
PHE A 205
ILE A  20
 AP5  A1217 (-4.3A)
None
None
None
 1.17A 4xv2B-5g3zA:
undetectable		 4xv2B-5g3zA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5g3z ADENYLATE KINSE
(synthetic
construct) 		4 / 7 ALA A 161
ASP A  33
GLY A 134
GLU A  18
 None
 1.03A 5bs8A-5g3zA:
undetectable
5bs8B-5g3zA:
undetectable
5bs8C-5g3zA:
undetectable		 5bs8A-5g3zA:
17.26
5bs8B-5g3zA:
23.70
5bs8C-5g3zA:
17.26