SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5g49'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 5g49 NUCLEAR
TRANSCRIPTION FACTOR
Y SUBUNIT B-6
(Arabidopsis
thaliana) 		4 / 6 TYR A  97
VAL A  68
ILE A  71
LEU A 138
 None
 1.21A 1j96A-5g49A:
undetectable		 1j96A-5g49A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 5g49 NUCLEAR
TRANSCRIPTION FACTOR
Y SUBUNIT B-6
(Arabidopsis
thaliana) 		4 / 4 LEU A 138
ILE A  71
ARG A  70
TYR A  97
 None
 1.48A 1rk3A-5g49A:
undetectable		 1rk3A-5g49A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 5g49 NUCLEAR
TRANSCRIPTION FACTOR
Y SUBUNIT B-6
NUCLEAR
TRANSCRIPTION FACTOR
Y SUBUNIT C-3
(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		3 / 3 PRO B  72
ASN A  67
ARG A  70
 None
 0.90A 2qeuB-5g49B:
undetectable		 2qeuB-5g49B:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 5g49 NUCLEAR
TRANSCRIPTION FACTOR
Y SUBUNIT B-6
NUCLEAR
TRANSCRIPTION FACTOR
Y SUBUNIT C-3
(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		4 / 7 GLU A 120
ARG A 146
GLU B  92
SER B  90
 None
 1.15A 2zt7A-5g49A:
undetectable		 2zt7A-5g49A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5g49 NUCLEAR
TRANSCRIPTION FACTOR
Y SUBUNIT B-6
(Arabidopsis
thaliana) 		5 / 12 ILE A  90
VAL A  68
ILE A  69
ILE A  82
SER A  83
 None
None
None
None
ACT  B1152 (-2.7A)
 1.19A 3kpbA-5g49A:
undetectable		 3kpbA-5g49A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5g49 NUCLEAR
TRANSCRIPTION FACTOR
Y SUBUNIT B-6
NUCLEAR
TRANSCRIPTION FACTOR
Y SUBUNIT C-3
(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		5 / 11 ILE A  90
THR B 109
ILE A  69
ILE A  82
SER A  83
 None
None
None
None
ACT  B1152 (-2.7A)
 1.20A 3kpcA-5g49A:
undetectable		 3kpcA-5g49A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5g49 NUCLEAR
TRANSCRIPTION FACTOR
Y SUBUNIT B-6
NUCLEAR
TRANSCRIPTION FACTOR
Y SUBUNIT C-3
(Arabidopsis
thaliana) 		5 / 12 PHE A 131
ILE B  76
LEU B  71
LEU B 106
PHE B 104
 None
 1.44A 3vn2A-5g49A:
undetectable		 3vn2A-5g49A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_A_NPSA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5g49 NUCLEAR
TRANSCRIPTION FACTOR
Y SUBUNIT B-6
(Arabidopsis
thaliana) 		5 / 9 VAL A  94
TYR A  97
VAL A  68
ILE A  71
LEU A 138
 None
 1.41A 4jq1A-5g49A:
undetectable		 4jq1A-5g49A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5g49 NUCLEAR
TRANSCRIPTION FACTOR
Y SUBUNIT B-6
NUCLEAR
TRANSCRIPTION FACTOR
Y SUBUNIT C-3
(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		4 / 5 LEU B 142
TYR A  97
LEU B 108
GLU B 107
 None
 1.35A 5weaA-5g49B:
undetectable		 5weaA-5g49B:
7.96