SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5g4g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 5g4g VCP-LIKE ATPASE
(Thermoplasma
acidophilum) 		6 / 12 ALA A 520
GLY A 470
LEU A 517
LEU A 472
LEU A 516
HIS A 648
 None
 1.24A 1ya4A-5g4gA:
undetectable		 1ya4A-5g4gA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5g4g VCP-LIKE ATPASE
(Thermoplasma
acidophilum) 		4 / 6 MET A  73
SER A  22
ARG A 127
GLY A  20
 None
 1.39A 2y7pA-5g4gA:
undetectable		 2y7pA-5g4gA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 5g4g VCP-LIKE ATPASE
(Thermoplasma
acidophilum) 		3 / 3 ARG A 416
GLU A 408
ASP A 401
 None
 0.92A 3g2oA-5g4gA:
3.1		 3g2oA-5g4gA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 5g4g VCP-LIKE ATPASE
(Thermoplasma
acidophilum) 		4 / 4 ARG A 407
ASP A 191
GLY A 193
THR A 235
 None
 1.49A 3k4vB-5g4gA:
undetectable		 3k4vB-5g4gA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5g4g VCP-LIKE ATPASE
(Thermoplasma
acidophilum) 		3 / 3 ASP A  70
ARG A  25
ALA A  14
 None
 0.74A 3mbgC-5g4gA:
undetectable		 3mbgC-5g4gA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 5g4g VCP-LIKE ATPASE
(Thermoplasma
acidophilum) 		4 / 7 SER A 453
GLY A 362
ASP A 359
GLU A 388
 None
 0.88A 4koeA-5g4gA:
undetectable
4koeB-5g4gA:
undetectable
4koeD-5g4gA:
undetectable		 4koeA-5g4gA:
21.39
4koeB-5g4gA:
21.39
4koeD-5g4gA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 5g4g VCP-LIKE ATPASE
(Thermoplasma
acidophilum) 		4 / 8 ALA A 686
VAL A 658
PHE A 701
GLY A 683
 None
 0.65A 4zjzA-5g4gA:
2.3		 4zjzA-5g4gA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5g4g VCP-LIKE ATPASE
(Thermoplasma
acidophilum) 		5 / 11 GLN A 108
ALA A 143
GLY A 144
THR A 146
ASP A 107
 None
 1.11A 5bxnH-5g4gA:
undetectable
5bxnI-5g4gA:
undetectable		 5bxnH-5g4gA:
15.51
5bxnI-5g4gA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5g4g VCP-LIKE ATPASE
(Thermoplasma
acidophilum) 		4 / 4 GLU A 568
THR A 611
THR A 585
LEU A 592
 None
 1.50A 5v96A-5g4gA:
undetectable		 5v96A-5g4gA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGG_Z_AG2Z503_0
(TRNA(ILE2)
2-AGMATINYLCYTIDINE
SYNTHETASE TIAS)		 5g4g VCP-LIKE ATPASE
(Thermoplasma
acidophilum) 		4 / 5 GLU A 182
ASN A  76
CYH A  77
ARG A 186
 None
 1.48A 6aggZ-5g4gA:
undetectable		 6aggZ-5g4gA:
7.88