SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5g4i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		4 / 8 SER A 402
LYS A 412
TYR A  61
PHE A  34
 None
PO4  A1442 (-3.2A)
PO4  A1442 (-4.5A)
None
 1.05A 1eqbA-5g4iA:
20.2
1eqbB-5g4iA:
20.6		 1eqbA-5g4iA:
24.15
1eqbB-5g4iA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		4 / 8 TYR A  61
PHE A  34
SER A 402
LYS A 412
 PO4  A1442 (-4.5A)
None
None
PO4  A1442 (-3.2A)
 1.06A 1eqbA-5g4iA:
20.2
1eqbB-5g4iA:
20.6		 1eqbA-5g4iA:
24.15
1eqbB-5g4iA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		4 / 8 SER A 402
LYS A 412
TYR A  61
PHE A  34
 None
PO4  A1442 (-3.2A)
PO4  A1442 (-4.5A)
None
 1.05A 1eqbC-5g4iA:
21.0
1eqbD-5g4iA:
20.8		 1eqbC-5g4iA:
24.15
1eqbD-5g4iA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		4 / 8 TYR A  61
PHE A  34
SER A 402
LYS A 412
 PO4  A1442 (-4.5A)
None
None
PO4  A1442 (-3.2A)
 1.06A 1eqbC-5g4iA:
21.0
1eqbD-5g4iA:
20.8		 1eqbC-5g4iA:
24.15
1eqbD-5g4iA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 435
LEU A 438
SER A 434
ILE A 373
PHE A 369
 None
 1.28A 1fmlA-5g4iA:
undetectable		 1fmlA-5g4iA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		5 / 12 SER A 194
VAL A 237
ILE A 234
PHE A 221
VAL A 198
 None
 1.00A 1qhsA-5g4iA:
2.3		 1qhsA-5g4iA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		5 / 12 ILE A 289
GLY A 290
GLY A 120
SER A 121
PRO A 282
 None
None
PLP  A1441 (-3.8A)
PLP  A1441 (-2.5A)
None
 0.95A 1vq1B-5g4iA:
2.3		 1vq1B-5g4iA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		5 / 11 LEU A 428
LEU A 431
LEU A 435
ILE A 345
THR A 387
 None
 0.87A 2qd3A-5g4iA:
undetectable		 2qd3A-5g4iA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		5 / 11 LEU A 428
LEU A 431
LEU A 435
THR A 387
VAL A 362
 None
 1.12A 2qd3A-5g4iA:
undetectable		 2qd3A-5g4iA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		4 / 8 LEU A 111
ARG A 242
PRO A 219
SER A 255
 None
 1.11A 2qd5A-5g4iA:
undetectable		 2qd5A-5g4iA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		5 / 12 SER A 222
HIS A 148
LEU A 229
ILE A 176
SER A 143
 None
 1.31A 2xrlA-5g4iA:
undetectable		 2xrlA-5g4iA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		5 / 11 ILE A 176
PHE A 217
PHE A 270
PRO A 177
ILE A 234
 None
 1.31A 2y7kA-5g4iA:
undetectable		 2y7kA-5g4iA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1304_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		5 / 10 ILE A 176
PHE A 217
PHE A 270
PRO A 177
ILE A 234
 None
 1.35A 2y7kB-5g4iA:
undetectable		 2y7kB-5g4iA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		4 / 6 TYR A  99
ALA A 100
LEU A 103
ALA A 291
 None
 0.70A 3b6hA-5g4iA:
undetectable		 3b6hA-5g4iA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		4 / 4 LEU A 438
PRO A 439
LEU A 386
ARG A 403
 None
 1.27A 3hcoA-5g4iA:
undetectable		 3hcoA-5g4iA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		3 / 3 ASP A 372
ASN A 409
SER A 180
 None
 0.71A 3lslA-5g4iA:
undetectable
3lslD-5g4iA:
undetectable		 3lslA-5g4iA:
19.52
3lslD-5g4iA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		3 / 3 SER A 180
ASP A 372
ASN A 409
 None
 0.66A 3lslA-5g4iA:
undetectable
3lslD-5g4iA:
undetectable		 3lslA-5g4iA:
19.52
3lslD-5g4iA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 128
ALA A 131
LEU A 247
ILE A 157
HIS A 170
 None
 1.20A 3olsB-5g4iA:
undetectable		 3olsB-5g4iA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		5 / 12 GLY A 261
GLY A 366
LYS A 337
ASP A 333
GLY A 258
 None
None
None
B3P  A1445 (-3.1A)
None
 1.05A 3sglA-5g4iA:
undetectable		 3sglA-5g4iA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		3 / 3 LYS A 281
SER A 222
GLN A 254
 PLP  A1441 (-1.4A)
None
PO4  A1442 ( 3.3A)
 1.29A 3si7A-5g4iA:
undetectable		 3si7A-5g4iA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA803_1
(CATALASE-PEROXIDASE)		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		4 / 4 ASP A 218
THR A 223
VAL A 253
SER A 146
 None
None
PLP  A1441 (-4.2A)
None
 1.45A 3wxoA-5g4iA:
undetectable		 3wxoA-5g4iA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 428
LEU A 431
LEU A 435
ILE A 345
THR A 387
 None
 0.81A 4f4dA-5g4iA:
undetectable		 4f4dA-5g4iA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 428
LEU A 431
LEU A 435
THR A 387
VAL A 362
 None
 1.06A 4f4dA-5g4iA:
undetectable		 4f4dA-5g4iA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 428
LEU A 431
LEU A 435
ILE A 345
THR A 387
 None
 0.84A 4f4dB-5g4iA:
undetectable		 4f4dB-5g4iA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 428
LEU A 431
LEU A 435
THR A 387
VAL A 362
 None
 1.09A 4f4dB-5g4iA:
undetectable		 4f4dB-5g4iA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		4 / 7 ARG A 242
PRO A 219
SER A 255
VAL A 272
 None
 1.34A 4kmmA-5g4iA:
undetectable		 4kmmA-5g4iA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		5 / 12 ALA A 291
GLY A 280
ILE A  78
ALA A 320
GLY A 322
 None
 1.05A 4r29D-5g4iA:
undetectable		 4r29D-5g4iA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		4 / 6 ALA A 201
ARG A 242
GLY A 246
GLU A 275
 None
 0.91A 5btgA-5g4iA:
1.8
5btgB-5g4iA:
undetectable
5btgC-5g4iA:
1.8		 5btgA-5g4iA:
24.06
5btgB-5g4iA:
19.24
5btgC-5g4iA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		4 / 9 ILE A 249
VAL A 292
THR A 294
ILE A 130
 None
 1.00A 5lg3I-5g4iA:
undetectable		 5lg3I-5g4iA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		4 / 6 PRO A 406
TYR A 233
LEU A 226
PHE A 221
 None
 1.15A 5tl8A-5g4iA:
undetectable		 5tl8A-5g4iA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 205
VAL A 212
ALA A 243
ALA A 244
GLY A 245
 None
 1.03A 5tzoB-5g4iA:
undetectable		 5tzoB-5g4iA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		3 / 3 GLY A 211
LEU A 205
HIS A 210
 None
 0.70A 5u63A-5g4iA:
undetectable		 5u63A-5g4iA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		3 / 3 GLY A 211
LEU A 205
HIS A 210
 None
 0.68A 5u63B-5g4iA:
undetectable		 5u63B-5g4iA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 5g4i PHOSPHOLYASE
(Paenarthrobacter
aurescens) 		5 / 10 ALA A 110
LEU A 111
ILE A 130
ALA A 127
LEU A 298
 None
 1.39A 6h1lA-5g4iA:
undetectable		 6h1lA-5g4iA:
21.50