SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5g4l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCL_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
N-ACETYL-D-HIS-L-PRO
-OH)		 5g4l OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Clostridium
sp.) 		4 / 5 TYR A 261
GLU A 224
PHE A 235
PRO A 198
 None
None
None
NDP  A1265 (-4.4A)
 1.31A 1mclA-5g4lA:
undetectable
1mclB-5g4lA:
undetectable
1mclP-5g4lA:
undetectable		 1mclA-5g4lA:
19.16
1mclB-5g4lA:
19.16
1mclP-5g4lA:
0.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5g4l OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Clostridium
sp.) 		5 / 12 VAL A 100
HIS A 102
ALA A 137
CYH A 133
VAL A 129
 None
NDP  A1265 (-4.9A)
None
None
None
 1.19A 2g70A-5g4lA:
6.5		 2g70A-5g4lA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5g4l OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Clostridium
sp.) 		5 / 12 VAL A 100
HIS A 102
ALA A 137
CYH A 133
VAL A 129
 None
NDP  A1265 (-4.9A)
None
None
None
 1.20A 2g70B-5g4lA:
6.1		 2g70B-5g4lA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5g4l OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Clostridium
sp.) 		5 / 12 VAL A 100
HIS A 102
ALA A 137
CYH A 133
VAL A 129
 None
NDP  A1265 (-4.9A)
None
None
None
 1.26A 2g72A-5g4lA:
6.3		 2g72A-5g4lA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5g4l OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Clostridium
sp.) 		5 / 12 VAL A 100
HIS A 102
ALA A 137
CYH A 133
VAL A 129
 None
NDP  A1265 (-4.9A)
None
None
None
 1.23A 2g72B-5g4lA:
6.6		 2g72B-5g4lA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1122_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5g4l OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Clostridium
sp.) 		4 / 7 SER A 195
VAL A 178
SER A 157
LYS A 158
 None
 1.38A 2j9cA-5g4lA:
undetectable
2j9cB-5g4lA:
undetectable
2j9cC-5g4lA:
undetectable		 2j9cA-5g4lA:
16.84
2j9cB-5g4lA:
16.84
2j9cC-5g4lA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 5g4l OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Clostridium
sp.) 		4 / 5 PHE A 235
ALA A 239
GLY A 237
TYR A 238
 None
 1.16A 3bcrA-5g4lA:
4.8		 3bcrA-5g4lA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 5g4l OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Clostridium
sp.) 		5 / 11 LEU A  33
LEU A 240
ALA A  42
VAL A  44
LYS A  18
 None
 1.17A 3e22B-5g4lA:
6.9		 3e22B-5g4lA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 5g4l OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Clostridium
sp.) 		5 / 11 LEU A  33
LEU A 240
ALA A  42
VAL A  44
LYS A  18
 None
 1.19A 3e22D-5g4lA:
6.8		 3e22D-5g4lA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 5g4l OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Clostridium
sp.) 		4 / 6 LEU A 205
ASN A 105
SER A 203
PHE A 201
 NDP  A1265 ( 4.6A)
None
NDP  A1265 ( 3.9A)
NDP  A1265 (-3.4A)
 1.30A 3i9jB-5g4lA:
2.8		 3i9jB-5g4lA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_A_T44A128_1
(TRANSTHYRETIN)		 5g4l OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Clostridium
sp.) 		5 / 9 LEU A 176
ALA A 174
SER A 157
THR A 153
VAL A 151
 None
 1.45A 3ozkA-5g4lA:
undetectable		 3ozkA-5g4lA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 5g4l OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Clostridium
sp.) 		4 / 6 THR A 153
GLY A 103
ASP A 125
ILE A 121
 None
NDP  A1265 (-3.3A)
NDP  A1265 ( 4.8A)
None
 1.01A 3w9tF-5g4lA:
undetectable		 3w9tF-5g4lA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5g4l OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Clostridium
sp.) 		4 / 7 GLU A  60
GLU A  64
PHE A  61
VAL A  15
 None
 1.05A 4a97A-5g4lA:
undetectable		 4a97A-5g4lA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5g4l OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Clostridium
sp.) 		4 / 7 GLU A  60
GLU A  64
PHE A  61
VAL A  15
 None
 1.10A 4a97D-5g4lA:
undetectable		 4a97D-5g4lA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 5g4l OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Clostridium
sp.) 		5 / 11 LEU A  33
LEU A 240
ALA A  42
VAL A  44
LYS A  18
 None
 1.15A 4x20D-5g4lA:
6.9		 4x20D-5g4lA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 5g4l OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Clostridium
sp.) 		3 / 3 VAL A  15
TYR A  37
ALA A  40
 None
 0.57A 4ybnA-5g4lA:
undetectable		 4ybnA-5g4lA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5g4l OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Clostridium
sp.) 		4 / 5 GLY A  24
PRO A 232
THR A 101
THR A  26
 NDP  A1265 ( 4.1A)
None
None
NDP  A1265 (-2.8A)
 1.19A 5h5fA-5g4lA:
undetectable		 5h5fA-5g4lA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 5g4l OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Clostridium
sp.) 		4 / 6 GLU A  60
LYS A  62
GLU A  58
ALA A  56
 None
 0.98A 6an0A-5g4lA:
4.3		 6an0A-5g4lA:
22.35