SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5g4x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_2
(HMG-COA REDUCTASE)		 5g4x SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3
(Rattus
norvegicus) 		5 / 11 ASN A 142
SER A 154
LEU A 153
ALA A 156
LEU A 166
 None
 1.47A 1hwkB-5g4xA:
undetectable		 1hwkB-5g4xA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_B_117B1_1
(HMG-COA REDUCTASE)		 5g4x SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3
(Rattus
norvegicus) 		5 / 11 ASN A 142
SER A 154
LEU A 153
ALA A 156
LEU A 166
 None
 1.45A 1hwkA-5g4xA:
undetectable		 1hwkA-5g4xA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_2
(HMG-COA REDUCTASE)		 5g4x SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3
(Rattus
norvegicus) 		5 / 11 ASN A 142
SER A 154
LEU A 153
ALA A 156
LEU A 166
 None
 1.44A 1hwkD-5g4xA:
undetectable		 1hwkD-5g4xA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_1
(HMG-COA REDUCTASE)		 5g4x SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3
(Rattus
norvegicus) 		5 / 11 ASN A 142
SER A 154
LEU A 153
ALA A 156
LEU A 166
 None
 1.45A 1hwkC-5g4xA:
undetectable		 1hwkC-5g4xA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 5g4x SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3
(Rattus
norvegicus) 		3 / 3 TRP A  33
VAL A  32
PRO A  31
 EDO  A1373 ( 3.9A)
None
None
 0.89A 1rg1A-5g4xA:
undetectable		 1rg1A-5g4xA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 5g4x SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3
(Rattus
norvegicus) 		3 / 3 TRP A  33
VAL A  32
PRO A  31
 EDO  A1373 ( 3.9A)
None
None
 0.88A 1rh0A-5g4xA:
undetectable		 1rh0A-5g4xA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 5g4x SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3
(Rattus
norvegicus) 		5 / 12 GLY A 206
ALA A 207
ASP A 177
ALA A 190
VAL A 187
 None
None
EDO  A1357 (-2.8A)
None
None
 0.95A 2b7zA-5g4xA:
undetectable		 2b7zA-5g4xA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 5g4x SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3
(Rattus
norvegicus) 		5 / 12 GLY A 206
ALA A 207
ASP A 177
ALA A 190
VAL A 187
 None
None
EDO  A1357 (-2.8A)
None
None
 1.03A 2b7zB-5g4xA:
undetectable		 2b7zB-5g4xA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5g4x SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3
(Rattus
norvegicus) 		3 / 3 LYS A  36
ASP A 210
ASP A 239
 EDO  A1377 (-2.3A)
None
None
 1.02A 2br4A-5g4xA:
undetectable		 2br4A-5g4xA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 5g4x SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3
(Rattus
norvegicus) 		3 / 3 ASP A 160
ASN A 161
THR A 128
 None
 0.71A 2pymB-5g4xA:
undetectable		 2pymB-5g4xA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 5g4x SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3
(Rattus
norvegicus) 		3 / 3 ASN A 115
LEU A 139
HIS A 111
 None
 0.80A 2q6fB-5g4xA:
undetectable		 2q6fB-5g4xA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 5g4x SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3
(Rattus
norvegicus) 		4 / 8 TYR A  87
GLY A  14
PRO A  16
GLU A  89
 None
None
EDO  A1354 ( 4.8A)
None
 1.03A 2ys6A-5g4xA:
undetectable		 2ys6A-5g4xA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 5g4x SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3
(Rattus
norvegicus) 		4 / 8 TYR A  53
ASN A  52
PRO A 141
PHE A 119
 EDO  A1354 (-4.6A)
None
None
None
 1.49A 3bjwD-5g4xA:
undetectable		 3bjwD-5g4xA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5g4x SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3
(Rattus
norvegicus) 		5 / 12 ALA A 274
LEU A 266
THR A 285
ILE A 289
LEU A 302
 None
 1.22A 3nrrA-5g4xA:
undetectable		 3nrrA-5g4xA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 5g4x SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3
(Rattus
norvegicus) 		4 / 6 ARG A 179
GLY A 183
ASP A 177
HIS A 175
 EDO  A1377 ( 4.2A)
None
EDO  A1357 (-2.8A)
EDO  A1357 (-4.0A)
 1.16A 4lajA-5g4xA:
undetectable
4lajB-5g4xA:
undetectable		 4lajA-5g4xA:
22.79
4lajB-5g4xA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 5g4x SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3
(Rattus
norvegicus) 		5 / 12 ALA A 174
LEU A 135
ASN A 171
VAL A 123
ALA A 156
 None
EDO  A1355 ( 4.4A)
None
None
None
 1.25A 4x1iB-5g4xA:
undetectable		 4x1iB-5g4xA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 5g4x SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3
(Rattus
norvegicus) 		4 / 6 LEU A  55
LEU A  43
LEU A  40
LEU A  24
 None
 0.97A 5gs4A-5g4xA:
undetectable		 5gs4A-5g4xA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5g4x SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3
(Rattus
norvegicus) 		4 / 7 GLY A  54
GLU A  70
PHE A  90
ASN A  52
 None
EDO  A1377 ( 4.4A)
None
None
 0.98A 5mvsA-5g4xA:
undetectable		 5mvsA-5g4xA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5g4x SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3
(Rattus
norvegicus) 		4 / 8 GLY A  54
GLU A  70
PHE A  90
ASN A  52
 None
EDO  A1377 ( 4.4A)
None
None
 0.95A 5mvsB-5g4xA:
undetectable		 5mvsB-5g4xA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5g4x SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3
(Rattus
norvegicus) 		4 / 5 PRO A   4
GLY A   5
VAL A   9
ARG A  25
 None
 1.11A 5x80C-5g4xA:
undetectable
5x80D-5g4xA:
undetectable		 5x80C-5g4xA:
20.18
5x80D-5g4xA:
20.18