SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5g51'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	5g51	DWV-VP3-P-DOMAIN (Deformed wing virus)	5 / 10	LEU A 364 VAL A 332 VAL A 286 GLY A 342 LEU A 358	None	1.45A	1fk9A-5g51A: undetectable	1fk9A-5g51A: 16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	5g51	DWV-VP3-P-DOMAIN (Deformed wing virus)	5 / 11	LEU A 364 VAL A 332 VAL A 286 GLY A 342 LEU A 358	None	1.39A	1jkhA-5g51A: undetectable 1jkhB-5g51A: undetectable	1jkhA-5g51A: 16.73 1jkhB-5g51A: 17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2E1Q_C_SALC4006_1 (XANTHINE DEHYDROGENASE/OXIDAS E)	5g51	DWV-VP3-P-DOMAIN (Deformed wing virus)	4 / 6	ARG A 352 VAL A 393 LEU A 312 ALA A 351	None	0.96A	2e1qC-5g51A: undetectable	2e1qC-5g51A: 7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OIP_A_MTXA605_1 (CHAIN A, CRYSTAL STRUCTURE OF DHFR)	5g51	DWV-VP3-P-DOMAIN (Deformed wing virus)	5 / 12	ALA A 310 LEU A 312 THR A 345 ILE A 343 LEU A 364	None	1.07A	2oipA-5g51A: undetectable	2oipA-5g51A: 14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HJ3_B_MTXB609_1 (CHAIN A, CRYSTAL STRUCTURE OF DHFR)	5g51	DWV-VP3-P-DOMAIN (Deformed wing virus)	5 / 12	ALA A 310 LEU A 312 THR A 345 ILE A 343 LEU A 364	None	1.10A	3hj3B-5g51A: undetectable	3hj3B-5g51A: 14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	5g51	DWV-VP3-P-DOMAIN (Deformed wing virus)	5 / 10	LEU A 364 VAL A 332 VAL A 286 GLY A 342 LEU A 358	None	1.34A	6bsgA-5g51A: undetectable	6bsgA-5g51A: 20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	5g51	DWV-VP3-P-DOMAIN (Deformed wing virus)	5 / 10	LEU A 364 VAL A 332 VAL A 286 GLY A 342 LEU A 358	None	1.30A	6bsiA-5g51A: undetectable	6bsiA-5g51A: 20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	5g51	DWV-VP3-P-DOMAIN (Deformed wing virus)	5 / 10	LEU A 364 VAL A 332 VAL A 286 GLY A 342 LEU A 358	None	1.33A	6bsjA-5g51A: undetectable	6bsjA-5g51A: 20.90

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1FK9_A_EFZA999_1","HIV-1 RT, A-CHAIN","5g51","DWV-VP3-P-DOMAIN","Deformed wing virus",5,"LEU A 364;VAL A 332;VAL A 286;GLY A 342;LEU A 358","None","1.45A","1fk9A-5g51A:undetectable","1fk9A-5g51A:16.73"],["1JKH_A_EFZA999_1","HIV-1 RT, A-CHAIN;HIV-1 RT, B-CHAIN","5g51","DWV-VP3-P-DOMAIN","Deformed wing virus",5,"LEU A 364;VAL A 332;VAL A 286;GLY A 342;LEU A 358","None","1.39A","1jkhA-5g51A:undetectable;1jkhB-5g51A:undetectable","1jkhA-5g51A:16.73;1jkhB-5g51A:17.74"],["2E1Q_C_SALC4006_1","XANTHINE DEHYDROGENASE\/OXIDASE","5g51","DWV-VP3-P-DOMAIN","Deformed wing virus",4,"ARG A 352;VAL A 393;LEU A 312;ALA A 351","None","0.96A","2e1qC-5g51A:undetectable","2e1qC-5g51A:7.65"],["2OIP_A_MTXA605_1","CHAIN A, CRYSTAL STRUCTURE OF DHFR","5g51","DWV-VP3-P-DOMAIN","Deformed wing virus",5,"ALA A 310;LEU A 312;THR A 345;ILE A 343;LEU A 364","None","1.07A","2oipA-5g51A:undetectable","2oipA-5g51A:14.62"],["3HJ3_B_MTXB609_1","CHAIN A, CRYSTAL STRUCTURE OF DHFR","5g51","DWV-VP3-P-DOMAIN","Deformed wing virus",5,"ALA A 310;LEU A 312;THR A 345;ILE A 343;LEU A 364","None","1.10A","3hj3B-5g51A:undetectable","3hj3B-5g51A:14.42"],["6BSG_A_EFZA601_1","REVERSE TRANSCRIPTASE P66 SUBUNIT","5g51","DWV-VP3-P-DOMAIN","Deformed wing virus",5,"LEU A 364;VAL A 332;VAL A 286;GLY A 342;LEU A 358","None","1.34A","6bsgA-5g51A:undetectable","6bsgA-5g51A:20.90"],["6BSI_A_EFZA601_1","REVERSE TRANSCRIPTASE P66 SUBUNIT","5g51","DWV-VP3-P-DOMAIN","Deformed wing virus",5,"LEU A 364;VAL A 332;VAL A 286;GLY A 342;LEU A 358","None","1.30A","6bsiA-5g51A:undetectable","6bsiA-5g51A:20.90"],["6BSJ_A_EFZA601_1","REVERSE TRANSCRIPTASE P66 SUBUNIT","5g51","DWV-VP3-P-DOMAIN","Deformed wing virus",5,"LEU A 364;VAL A 332;VAL A 286;GLY A 342;LEU A 358","None","1.33A","6bsjA-5g51A:undetectable","6bsjA-5g51A:20.90"]]