SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5g53'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5g53 ADENOSINE RECEPTOR
A2A
(Homo
sapiens) 		5 / 10 ALA A  81
SER A 132
PHE A 133
LEU A 137
PHE A  83
 None
 1.27A 1g5yC-5g53A:
undetectable		 1g5yC-5g53A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 5g53 ADENOSINE RECEPTOR
A2A
(Homo
sapiens) 		5 / 11 ALA A  81
PHE A  79
LEU A 137
VAL A 171
VAL A 172
 None
 1.14A 1ukbA-5g53A:
undetectable		 1ukbA-5g53A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 5g53 ADENOSINE RECEPTOR
A2A
ENGINEERED DOMAIN OF
HUMAN G ALPHA S LONG
ISOFORM
(Homo
sapiens) 		4 / 6 LEU C 393
TYR C 391
ILE A 238
ILE A 200
 None
 1.01A 2q8hA-5g53C:
undetectable		 2q8hA-5g53C:
18.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 5g53 ADENOSINE RECEPTOR
A2A
(Homo
sapiens) 		12 / 12 LEU A  85
THR A  88
PHE A 168
GLU A 169
MET A 177
TRP A 246
LEU A 249
ASN A 253
MET A 270
ILE A 274
SER A 277
HIS A 278
 NEC  A 400 (-4.9A)
NEC  A 400 (-3.7A)
NEC  A 400 (-3.6A)
NEC  A 400 (-4.0A)
NEC  A 400 (-4.8A)
None
NEC  A 400 ( 4.6A)
NEC  A 400 (-3.3A)
None
NEC  A 400 (-4.6A)
NEC  A 400 (-2.7A)
NEC  A 400 (-3.6A)
 0.30A 2ydoA-5g53A:
38.3		 2ydoA-5g53A:
95.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 5g53 ADENOSINE RECEPTOR
A2A
(Homo
sapiens) 		3 / 3 CYH A 254
PHE A 257
PHE A 258
 None
 0.63A 3cr5X-5g53A:
undetectable		 3cr5X-5g53A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5g53 ADENOSINE RECEPTOR
A2A
ENGINEERED DOMAIN OF
HUMAN G ALPHA S LONG
ISOFORM
(Homo
sapiens) 		5 / 12 PHE A  44
HIS C 387
TYR C 391
LEU A  95
TYR A 112
 None
 1.36A 3dzyD-5g53A:
2.8		 3dzyD-5g53A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 5g53 ADENOSINE RECEPTOR
A2A
(Homo
sapiens) 		5 / 11 ALA A  97
ILE A  98
SER A  94
LEU A  48
VAL A  46
 None
 0.89A 3gyqB-5g53A:
undetectable		 3gyqB-5g53A:
23.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 5g53 ADENOSINE RECEPTOR
A2A
(Homo
sapiens) 		5 / 7 MET A 174
LEU A 249
ASN A 253
MET A 270
ILE A 274
 NEC  A 400 ( 4.8A)
NEC  A 400 ( 4.6A)
NEC  A 400 (-3.3A)
None
NEC  A 400 (-4.6A)
 1.44A 3rfmA-5g53A:
30.6		 3rfmA-5g53A:
91.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 5g53 ADENOSINE RECEPTOR
A2A
(Homo
sapiens) 		6 / 7 VAL A  84
PHE A 168
MET A 177
LEU A 249
ASN A 253
ILE A 274
 None
NEC  A 400 (-3.6A)
NEC  A 400 (-4.8A)
NEC  A 400 ( 4.6A)
NEC  A 400 (-3.3A)
NEC  A 400 (-4.6A)
 1.04A 3rfmA-5g53A:
30.6		 3rfmA-5g53A:
91.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5g53 ADENOSINE RECEPTOR
A2A
(Homo
sapiens) 		4 / 4 ASN A  24
SER A  91
ALA A  49
VAL A  46
 None
 1.27A 4x1kC-5g53A:
undetectable		 4x1kC-5g53A:
20.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 5g53 ADENOSINE RECEPTOR
A2A
(Homo
sapiens) 		8 / 8 LEU A  85
PHE A 168
GLU A 169
MET A 177
LEU A 249
ASN A 253
MET A 270
ILE A 274
 NEC  A 400 (-4.9A)
NEC  A 400 (-3.6A)
NEC  A 400 (-4.0A)
NEC  A 400 (-4.8A)
NEC  A 400 ( 4.6A)
NEC  A 400 (-3.3A)
None
NEC  A 400 (-4.6A)
 0.58A 5mzjA-5g53A:
31.8		 5mzjA-5g53A:
70.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MZP_A_CFFA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 5g53 ADENOSINE RECEPTOR
A2A
(Homo
sapiens) 		8 / 9 ILE A  66
PHE A 168
GLU A 169
MET A 177
LEU A 249
ASN A 253
MET A 270
ILE A 274
 None
NEC  A 400 (-3.6A)
NEC  A 400 (-4.0A)
NEC  A 400 (-4.8A)
NEC  A 400 ( 4.6A)
NEC  A 400 (-3.3A)
None
NEC  A 400 (-4.6A)
 0.48A 5mzpA-5g53A:
31.7		 5mzpA-5g53A:
70.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MZP_A_CFFA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 5g53 ADENOSINE RECEPTOR
A2A
(Homo
sapiens) 		8 / 9 VAL A  84
PHE A 168
GLU A 169
MET A 177
LEU A 249
ASN A 253
MET A 270
ILE A 274
 None
NEC  A 400 (-3.6A)
NEC  A 400 (-4.0A)
NEC  A 400 (-4.8A)
NEC  A 400 ( 4.6A)
NEC  A 400 (-3.3A)
None
NEC  A 400 (-4.6A)
 0.82A 5mzpA-5g53A:
31.7		 5mzpA-5g53A:
70.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5g53 ADENOSINE RECEPTOR
A2A
(Homo
sapiens) 		4 / 4 ASN A  24
SER A  91
ALA A  49
VAL A  46
 None
 1.19A 5nm5A-5g53A:
undetectable		 5nm5A-5g53A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODH_G_ACTG710_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5g53 ADENOSINE RECEPTOR
A2A
(Homo
sapiens) 		4 / 4 ARG A 291
ILE A 238
TYR A 197
ILE A 200
 None
 1.33A 5odhG-5g53A:
undetectable		 5odhG-5g53A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 5g53 ADENOSINE RECEPTOR
A2A
(Homo
sapiens) 		5 / 12 LEU A 194
MET A 193
LEU A 192
ILE A  92
LEU A  96
 None
 1.12A 5toaB-5g53A:
undetectable		 5toaB-5g53A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 5g53 ADENOSINE RECEPTOR
A2A
(Homo
sapiens) 		5 / 12 LEU A 194
MET A 193
LEU A 192
LEU A  96
LEU A 247
 None
 1.14A 5toaB-5g53A:
undetectable		 5toaB-5g53A:
20.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 5g53 ADENOSINE RECEPTOR
A2A
(Homo
sapiens) 		4 / 6 ASN A  39
THR A  41
ASN A  42
ILE A 292
 None
 0.71A 5uigA-5g53A:
30.2		 5uigA-5g53A:
69.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5g53 ADENOSINE RECEPTOR
A2A
ENGINEERED DOMAIN OF
HUMAN G ALPHA S LONG
ISOFORM
(Homo
sapiens;
Homo
sapiens) 		3 / 3 GLU C 392
TYR C 391
ARG A 102
 None
 0.65A 5uunA-5g53C:
undetectable		 5uunA-5g53C:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5g53 ADENOSINE RECEPTOR
A2A
ENGINEERED DOMAIN OF
HUMAN G ALPHA S LONG
ISOFORM
(Homo
sapiens;
Homo
sapiens) 		3 / 3 GLU C 392
TYR C 391
ARG A 102
 None
 0.78A 5uunB-5g53C:
undetectable		 5uunB-5g53C:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 5g53 ADENOSINE RECEPTOR
A2A
(Homo
sapiens) 		4 / 4 PHE A 180
LEU A  96
LEU A 131
VAL A 188
 None
 1.12A 5xxiA-5g53A:
undetectable		 5xxiA-5g53A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 5g53 ENGINEERED DOMAIN OF
HUMAN G ALPHA S LONG
ISOFORM
(Homo
sapiens) 		4 / 4 PHE C 363
LEU C 270
LEU C 346
VAL C 248
 None
 1.17A 5xxiA-5g53C:
undetectable		 5xxiA-5g53C:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5g53 ENGINEERED DOMAIN OF
HUMAN G ALPHA S LONG
ISOFORM
(Homo
sapiens) 		3 / 3 LYS C 274
ASN C 278
SER C 352
 None
 1.24A 5yw0A-5g53C:
undetectable		 5yw0A-5g53C:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5g53 ADENOSINE RECEPTOR
A2A
(Homo
sapiens) 		5 / 12 ILE A 200
ALA A 203
ALA A 204
GLN A 207
ILE A 238
 None
 1.23A 6a5zD-5g53A:
2.6		 6a5zD-5g53A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 5g53 ADENOSINE RECEPTOR
A2A
(Homo
sapiens) 		8 / 10 THR A  88
PHE A 168
GLU A 169
MET A 177
LEU A 249
ASN A 253
ILE A 274
HIS A 278
 NEC  A 400 (-3.7A)
NEC  A 400 (-3.6A)
NEC  A 400 (-4.0A)
NEC  A 400 (-4.8A)
NEC  A 400 ( 4.6A)
NEC  A 400 (-3.3A)
NEC  A 400 (-4.6A)
NEC  A 400 (-3.6A)
 0.89A 6d9hR-5g53A:
35.8		 6d9hR-5g53A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 5g53 ADENOSINE RECEPTOR
A2A
(Homo
sapiens) 		8 / 10 VAL A  84
THR A  88
PHE A 168
MET A 177
LEU A 249
ASN A 253
ILE A 274
HIS A 278
 None
NEC  A 400 (-3.7A)
NEC  A 400 (-3.6A)
NEC  A 400 (-4.8A)
NEC  A 400 ( 4.6A)
NEC  A 400 (-3.3A)
NEC  A 400 (-4.6A)
NEC  A 400 (-3.6A)
 0.45A 6d9hR-5g53A:
35.8		 6d9hR-5g53A:
15.38