SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5g5a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 5g5a GLUTATHIONE
S-TRANSFERASE U25
(Arabidopsis
thaliana) 		3 / 3 TRP A 114
VAL A 106
TRP A 163
 None
 1.01A 1c4dA-5g5aA:
undetectable
1c4dB-5g5aA:
undetectable		 1c4dA-5g5aA:
9.88
1c4dB-5g5aA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5g5a GLUTATHIONE
S-TRANSFERASE U25
(Arabidopsis
thaliana) 		4 / 7 ILE A 175
PRO A 200
GLY A 159
MET A  14
 None
None
None
GSH  A1222 ( 4.5A)
 1.23A 2pnjB-5g5aA:
undetectable		 2pnjB-5g5aA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 5g5a GLUTATHIONE
S-TRANSFERASE U25
(Arabidopsis
thaliana) 		5 / 6 PHE A  15
ARG A  18
PRO A  55
GLU A  66
SER A  67
 GSH  A1221 (-4.4A)
GSH  A1221 ( 4.9A)
GSH  A1221 (-4.3A)
GSH  A1221 (-3.0A)
GSH  A1221 (-2.6A)
 0.44A 3vlnA-5g5aA:
24.4		 3vlnA-5g5aA:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC392_1
(TETX2 PROTEIN)		 5g5a GLUTATHIONE
S-TRANSFERASE U25
(Arabidopsis
thaliana) 		5 / 12 TYR A 161
PHE A 164
VAL A 106
ILE A 131
ILE A 113
 None
 1.44A 4a99A-5g5aA:
undetectable
4a99C-5g5aA:
undetectable		 4a99A-5g5aA:
19.59
4a99C-5g5aA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5g5a GLUTATHIONE
S-TRANSFERASE U25
(Arabidopsis
thaliana) 		4 / 8 SER A  67
ARG A  18
GLU A  72
ILE A  71
 GSH  A1221 (-2.6A)
GSH  A1221 ( 4.9A)
None
None
 1.15A 4d33A-5g5aA:
undetectable		 4d33A-5g5aA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5g5a GLUTATHIONE
S-TRANSFERASE U25
(Arabidopsis
thaliana) 		4 / 6 ILE A  54
GLY A  16
ILE A 205
LEU A  37
 GSH  A1221 (-4.1A)
None
None
GSH  A1221 ( 4.1A)
 0.77A 4o8fB-5g5aA:
undetectable		 4o8fB-5g5aA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5g5a GLUTATHIONE
S-TRANSFERASE U25
(Arabidopsis
thaliana) 		4 / 6 PHE A  15
GLY A  16
ILE A 205
LEU A  37
 GSH  A1221 (-4.4A)
None
None
GSH  A1221 ( 4.1A)
 0.69A 4o8fB-5g5aA:
undetectable		 4o8fB-5g5aA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 5g5a GLUTATHIONE
S-TRANSFERASE U25
(Arabidopsis
thaliana) 		5 / 12 ASP A   3
VAL A   5
LEU A  23
THR A  19
ALA A  22
 None
 1.35A 4yhaA-5g5aA:
undetectable		 4yhaA-5g5aA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5g5a GLUTATHIONE
S-TRANSFERASE U25
(Arabidopsis
thaliana) 		5 / 12 GLY A 151
GLY A 146
THR A 143
ILE A  71
LEU A  84
 None
 1.18A 5bw4A-5g5aA:
undetectable		 5bw4A-5g5aA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 5g5a GLUTATHIONE
S-TRANSFERASE U25
(Arabidopsis
thaliana) 		5 / 12 ALA A 116
LEU A 132
PHE A 128
GLY A 186
PHE A 173
 None
 1.14A 5fsaA-5g5aA:
undetectable		 5fsaA-5g5aA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5g5a GLUTATHIONE
S-TRANSFERASE U25
(Arabidopsis
thaliana) 		4 / 6 TYR A  73
ASP A   3
HIS A  59
ILE A   6
 None
 1.29A 5ih0A-5g5aA:
undetectable		 5ih0A-5g5aA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5g5a GLUTATHIONE
S-TRANSFERASE U25
(Arabidopsis
thaliana) 		4 / 8 PHE A 150
PHE A  30
VAL A  28
ILE A  71
 None
 1.00A 5vkqB-5g5aA:
undetectable
5vkqC-5g5aA:
undetectable		 5vkqB-5g5aA:
8.22
5vkqC-5g5aA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 5g5a GLUTATHIONE
S-TRANSFERASE U25
(Arabidopsis
thaliana) 		4 / 7 TYR A  73
HIS A  59
LEU A  23
VAL A  28
 None
 1.21A 6g2pA-5g5aA:
undetectable		 6g2pA-5g5aA:
20.43