SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5g5t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 5g5t ARGONAUTE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 684
TYR A 522
VAL A 520
ILE A 531
LEU A 678
 None
 1.24A 1fm4A-5g5tA:
undetectable		 1fm4A-5g5tA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 5g5t ARGONAUTE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 534
TYR A 547
LEU A 545
LEU A 552
ILE A 549
 None
 1.01A 1fmlB-5g5tA:
undetectable		 1fmlB-5g5tA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 5g5t ARGONAUTE
(Methanocaldococc
us
jannaschii) 		4 / 5 LYS A 354
LEU A 356
MET A 481
LEU A 343
 None
 1.08A 1skxA-5g5tA:
undetectable		 1skxA-5g5tA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5g5t ARGONAUTE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 482
LEU A 704
LEU A 710
PRO A 348
ILE A 350
 None
None
None
SO4  A1721 ( 4.5A)
None
 1.27A 1zq9A-5g5tA:
undetectable		 1zq9A-5g5tA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_A_BEZA1162_0
(PEROXIREDOXIN-5)		 5g5t ARGONAUTE
(Methanocaldococc
us
jannaschii) 		5 / 10 PRO A 533
CYH A 518
LEU A 710
PHE A 712
GLY A 708
 None
 1.22A 2vl2A-5g5tA:
undetectable
2vl2C-5g5tA:
undetectable		 2vl2A-5g5tA:
14.62
2vl2C-5g5tA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5g5t ARGONAUTE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 477
ILE A 486
ILE A 387
TYR A 384
PHE A 381
 None
 1.44A 4a79A-5g5tA:
undetectable		 4a79A-5g5tA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1480_0
(MJ0495-LIKE PROTEIN)		 5g5t ARGONAUTE
(Methanocaldococc
us
jannaschii) 		4 / 4 LYS A 582
GLU A 550
ILE A 584
SER A 585
 None
 1.34A 4ac9C-5g5tA:
4.8		 4ac9C-5g5tA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1480_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5g5t ARGONAUTE
(Methanocaldococc
us
jannaschii) 		4 / 4 LYS A 582
GLU A 550
ILE A 584
SER A 585
 None
 1.28A 4acaC-5g5tA:
4.9		 4acaC-5g5tA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1480_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5g5t ARGONAUTE
(Methanocaldococc
us
jannaschii) 		4 / 4 LYS A 582
GLU A 550
ILE A 584
SER A 585
 None
 1.34A 4acbC-5g5tA:
2.4		 4acbC-5g5tA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 5g5t ARGONAUTE
(Methanocaldococc
us
jannaschii) 		4 / 7 ARG A 641
TYR A 497
LEU A 659
ASN A 653
 None
 1.13A 4f8yC-5g5tA:
undetectable
4f8yD-5g5tA:
2.9		 4f8yC-5g5tA:
14.10
4f8yD-5g5tA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5g5t ARGONAUTE
(Methanocaldococc
us
jannaschii) 		4 / 8 TYR A 677
PHE A 489
GLY A 526
ILE A 500
 None
 0.94A 4qoiA-5g5tA:
2.7
4qoiB-5g5tA:
undetectable		 4qoiA-5g5tA:
15.33
4qoiB-5g5tA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 5g5t ARGONAUTE
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A 584
LEU A 581
ILE A 549
LEU A 545
 None
 0.83A 4zvcA-5g5tA:
undetectable
4zvcB-5g5tA:
undetectable		 4zvcA-5g5tA:
10.25
4zvcB-5g5tA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 5g5t ARGONAUTE
(Methanocaldococc
us
jannaschii) 		4 / 5 TYR A 677
PHE A 622
HIS A 685
PRO A 624
 None
 1.41A 5csyB-5g5tA:
undetectable		 5csyB-5g5tA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5g5t ARGONAUTE
(Methanocaldococc
us
jannaschii) 		5 / 9 LEU A 503
ILE A 534
ILE A 592
GLU A 593
GLU A 577
 None
 1.16A 5igzA-5g5tA:
undetectable		 5igzA-5g5tA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 5g5t ARGONAUTE
(Methanocaldococc
us
jannaschii) 		3 / 3 TYR A 150
ASP A 296
ASP A 148
 None
SO4  A1719 (-4.1A)
None
 0.56A 5x6yA-5g5tA:
1.9		 5x6yA-5g5tA:
22.77