SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5g5x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 5g5x SITE-2 PROTEASE
NANOBODY
(Archaeoglobus
fulgidus;
Lama
glama) 		5 / 12 PRO A 247
GLY A 293
LEU A 257
SER B  56
PHE B  54
 None
 1.47A 2b9eA-5g5xA:
undetectable		 2b9eA-5g5xA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 5g5x NANOBODY
SITE-2 PROTEASE
(Archaeoglobus
fulgidus;
Lama
glama) 		5 / 12 SER B  56
THR B  52
THR B  96
VAL A 292
VAL A 275
 None
 1.19A 2nniA-5g5xB:
undetectable		 2nniA-5g5xB:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5g5x SITE-2 PROTEASE
(Archaeoglobus
fulgidus) 		6 / 12 ILE A 277
THR A 279
ASP A 282
VAL A 300
ILE A 321
PRO A 325
 ATP  A1355 (-4.1A)
ATP  A1355 (-2.4A)
ATP  A1355 (-1.9A)
ATP  A1355 (-3.8A)
ATP  A1355 (-4.5A)
None
 0.56A 3kpbA-5g5xA:
17.2		 3kpbA-5g5xA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5g5x SITE-2 PROTEASE
(Archaeoglobus
fulgidus) 		6 / 12 ILE A 277
THR A 279
ASP A 282
VAL A 300
ILE A 321
PRO A 325
 ATP  A1355 (-4.1A)
ATP  A1355 (-2.4A)
ATP  A1355 (-1.9A)
ATP  A1355 (-3.8A)
ATP  A1355 (-4.5A)
None
 0.56A 3kpbC-5g5xA:
17.3		 3kpbC-5g5xA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5g5x SITE-2 PROTEASE
(Archaeoglobus
fulgidus) 		5 / 10 ILE A 277
THR A 279
ASP A 282
VAL A 300
ILE A 321
 ATP  A1355 (-4.1A)
ATP  A1355 (-2.4A)
ATP  A1355 (-1.9A)
ATP  A1355 (-3.8A)
ATP  A1355 (-4.5A)
 0.62A 3kpbD-5g5xA:
17.3		 3kpbD-5g5xA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5g5x SITE-2 PROTEASE
(Archaeoglobus
fulgidus) 		6 / 11 ILE A 277
THR A 279
ASP A 282
VAL A 300
ILE A 321
PRO A 325
 ATP  A1355 (-4.1A)
ATP  A1355 (-2.4A)
ATP  A1355 (-1.9A)
ATP  A1355 (-3.8A)
ATP  A1355 (-4.5A)
None
 0.58A 3kpcA-5g5xA:
17.7		 3kpcA-5g5xA:
29.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5g5x SITE-2 PROTEASE
(Archaeoglobus
fulgidus) 		6 / 12 ILE A 277
THR A 279
ASP A 282
VAL A 300
ILE A 321
PRO A 325
 ATP  A1355 (-4.1A)
ATP  A1355 (-2.4A)
ATP  A1355 (-1.9A)
ATP  A1355 (-3.8A)
ATP  A1355 (-4.5A)
None
 0.55A 3kpdB-5g5xA:
17.0		 3kpdB-5g5xA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 5g5x SITE-2 PROTEASE
(Archaeoglobus
fulgidus) 		6 / 12 ILE A 277
THR A 279
ASP A 282
VAL A 300
ILE A 321
PRO A 325
 ATP  A1355 (-4.1A)
ATP  A1355 (-2.4A)
ATP  A1355 (-1.9A)
ATP  A1355 (-3.8A)
ATP  A1355 (-4.5A)
None
 0.60A 3kpdC-5g5xA:
17.1		 3kpdC-5g5xA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5g5x SITE-2 PROTEASE
(Archaeoglobus
fulgidus) 		6 / 12 ILE A 278
GLY A 265
HIS A 263
VAL A 243
VAL A 242
MET A 296
 None
None
AMP  A1354 (-3.4A)
AMP  A1354 (-3.6A)
AMP  A1354 (-3.9A)
None
 1.42A 5n0wA-5g5xA:
undetectable		 5n0wA-5g5xA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5g5x SITE-2 PROTEASE
(Archaeoglobus
fulgidus) 		6 / 12 ILE A 278
GLY A 265
HIS A 263
VAL A 243
VAL A 242
MET A 296
 None
None
AMP  A1354 (-3.4A)
AMP  A1354 (-3.6A)
AMP  A1354 (-3.9A)
None
 1.43A 5n0wB-5g5xA:
undetectable		 5n0wB-5g5xA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5g5x SITE-2 PROTEASE
(Archaeoglobus
fulgidus) 		6 / 12 ILE A 278
GLY A 265
HIS A 263
VAL A 243
VAL A 242
MET A 296
 None
None
AMP  A1354 (-3.4A)
AMP  A1354 (-3.6A)
AMP  A1354 (-3.9A)
None
 1.44A 5n4iA-5g5xA:
undetectable		 5n4iA-5g5xA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 5g5x SITE-2 PROTEASE
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 269
PRO A 267
GLY A 265
VAL A 254
ILE A 283
 None
AMP  A1354 (-4.8A)
None
None
None
 1.29A 5tuiB-5g5xA:
undetectable		 5tuiB-5g5xA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 5g5x SITE-2 PROTEASE
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 257
ASP A 282
VAL A 251
GLY A 293
VAL A 254
 None
ATP  A1355 (-1.9A)
None
None
None
 0.98A 6dh0A-5g5xA:
undetectable		 6dh0A-5g5xA:
20.74