SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5g6r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		 5g6r IMINE REDUCTASE
(Aspergillus
oryzae) 		5 / 12 ASN A  93
GLY A  94
GLN A  98
LEU A 102
ILE A 118
 NDP  A1000 (-3.5A)
None
None
None
NDP  A1000 (-4.3A)
 1.47A 1p93B-5g6rA:
undetectable		 1p93B-5g6rA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5g6r IMINE REDUCTASE
(Aspergillus
oryzae) 		5 / 12 GLY A   9
GLY A  11
ALA A  16
LEU A  17
VAL A  71
 NDP  A1000 (-3.5A)
NDP  A1000 (-3.3A)
None
None
NDP  A1000 (-4.4A)
 1.04A 2zulA-5g6rA:
6.1		 2zulA-5g6rA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5g6r IMINE REDUCTASE
(Aspergillus
oryzae) 		5 / 12 GLY A   9
GLY A  11
ALA A  16
LEU A  17
VAL A  71
 NDP  A1000 (-3.5A)
NDP  A1000 (-3.3A)
None
None
NDP  A1000 (-4.4A)
 1.02A 3dmhA-5g6rA:
6.3		 3dmhA-5g6rA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 5g6r IMINE REDUCTASE
(Aspergillus
oryzae) 		5 / 12 GLY A 117
LEU A 133
ALA A 162
ASP A 161
SER A 135
 None
 0.89A 3tbgB-5g6rA:
undetectable		 3tbgB-5g6rA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 5g6r IMINE REDUCTASE
(Aspergillus
oryzae) 		5 / 12 GLY A 117
LEU A 133
ALA A 162
ASP A 161
SER A 135
 None
 0.91A 3tbgD-5g6rA:
undetectable		 3tbgD-5g6rA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5g6r IMINE REDUCTASE
(Aspergillus
oryzae) 		5 / 12 LEU A  22
TYR A  26
GLY A   6
LEU A  41
GLY A  14
 None
None
None
None
NDP  A1000 ( 4.9A)
 1.12A 4blvA-5g6rA:
2.1		 4blvA-5g6rA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5g6r IMINE REDUCTASE
(Aspergillus
oryzae) 		5 / 12 ALA A  38
GLY A  11
GLY A   9
LEU A  67
LEU A  66
 None
NDP  A1000 (-3.3A)
NDP  A1000 (-3.5A)
NDP  A1000 (-3.8A)
NDP  A1000 (-4.4A)
 1.01A 4lg1A-5g6rA:
5.7		 4lg1A-5g6rA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5g6r IMINE REDUCTASE
(Aspergillus
oryzae) 		5 / 12 ALA A  38
GLY A  11
GLY A   9
LEU A  67
LEU A  66
 None
NDP  A1000 (-3.3A)
NDP  A1000 (-3.5A)
NDP  A1000 (-3.8A)
NDP  A1000 (-4.4A)
 0.99A 4lg1B-5g6rA:
5.5		 4lg1B-5g6rA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5g6r IMINE REDUCTASE
(Aspergillus
oryzae) 		5 / 12 ALA A  38
GLY A  11
GLY A   9
LEU A  67
LEU A  66
 None
NDP  A1000 (-3.3A)
NDP  A1000 (-3.5A)
NDP  A1000 (-3.8A)
NDP  A1000 (-4.4A)
 1.03A 4lg1C-5g6rA:
5.3		 4lg1C-5g6rA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 5g6r IMINE REDUCTASE
(Aspergillus
oryzae) 		5 / 12 ASN A  93
GLY A  94
GLN A  98
LEU A 102
ILE A 118
 NDP  A1000 (-3.5A)
None
None
None
NDP  A1000 (-4.3A)
 1.44A 4p6xA-5g6rA:
undetectable		 4p6xA-5g6rA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 5g6r IMINE REDUCTASE
(Aspergillus
oryzae) 		5 / 12 ASN A  93
GLY A  94
GLN A  98
LEU A 102
ILE A 118
 NDP  A1000 (-3.5A)
None
None
None
NDP  A1000 (-4.3A)
 1.46A 4p6xE-5g6rA:
undetectable		 4p6xE-5g6rA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		 5g6r IMINE REDUCTASE
(Aspergillus
oryzae) 		5 / 12 ASN A  93
GLY A  94
GLN A  98
LEU A 102
ILE A 118
 NDP  A1000 (-3.5A)
None
None
None
NDP  A1000 (-4.3A)
 1.48A 4p6xG-5g6rA:
undetectable		 4p6xG-5g6rA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 5g6r IMINE REDUCTASE
(Aspergillus
oryzae) 		5 / 12 ASN A  93
GLY A  94
GLN A  98
LEU A 102
ILE A 118
 NDP  A1000 (-3.5A)
None
None
None
NDP  A1000 (-4.3A)
 1.45A 4p6xI-5g6rA:
undetectable		 4p6xI-5g6rA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 5g6r IMINE REDUCTASE
(Aspergillus
oryzae) 		5 / 11 GLY A 117
LEU A 133
ALA A 162
ASP A 161
SER A 135
 None
 1.11A 4wnuC-5g6rA:
undetectable		 4wnuC-5g6rA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 5g6r IMINE REDUCTASE
(Aspergillus
oryzae) 		5 / 12 GLY A 117
LEU A 133
ALA A 162
ASP A 161
SER A 135
 None
 0.88A 4wnwB-5g6rA:
undetectable		 4wnwB-5g6rA:
21.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5G6S_A_RAUA400_1
(IMINE REDUCTASE)		 5g6r IMINE REDUCTASE
(Aspergillus
oryzae) 		5 / 11 VAL A 121
LEU A 173
MET A 176
TYR A 177
PHE A 180
 NDP  A1000 ( 4.7A)
None
None
None
None
 0.59A 5g6sA-5g6rA:
37.9
5g6sG-5g6rA:
37.7		 5g6sA-5g6rA:
100.00
5g6sG-5g6rA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5G6S_B_RAUB400_1
(IMINE REDUCTASE)		 5g6r IMINE REDUCTASE
(Aspergillus
oryzae) 		5 / 11 VAL A 121
LEU A 173
MET A 176
TYR A 177
PHE A 180
 NDP  A1000 ( 4.7A)
None
None
None
None
 0.66A 5g6sB-5g6rA:
37.8
5g6sC-5g6rA:
37.9		 5g6sB-5g6rA:
100.00
5g6sC-5g6rA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5G6S_C_RAUC400_1
(IMINE REDUCTASE)		 5g6r IMINE REDUCTASE
(Aspergillus
oryzae) 		5 / 12 VAL A 121
LEU A 173
MET A 176
TYR A 177
PHE A 180
 NDP  A1000 ( 4.7A)
None
None
None
None
 0.59A 5g6sB-5g6rA:
37.8
5g6sC-5g6rA:
37.9		 5g6sB-5g6rA:
100.00
5g6sC-5g6rA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5G6S_D_RAUD400_1
(IMINE REDUCTASE)		 5g6r IMINE REDUCTASE
(Aspergillus
oryzae) 		5 / 10 VAL A 121
LEU A 173
MET A 176
TYR A 177
PHE A 180
 NDP  A1000 ( 4.7A)
None
None
None
None
 0.59A 5g6sD-5g6rA:
37.9
5g6sF-5g6rA:
37.8		 5g6sD-5g6rA:
100.00
5g6sF-5g6rA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5G6S_E_RAUE400_1
(IMINE REDUCTASE)		 5g6r IMINE REDUCTASE
(Aspergillus
oryzae) 		5 / 11 VAL A 121
LEU A 173
MET A 176
TYR A 177
PHE A 180
 NDP  A1000 ( 4.7A)
None
None
None
None
 0.59A 5g6sE-5g6rA:
37.9
5g6sH-5g6rA:
37.7		 5g6sE-5g6rA:
100.00
5g6sH-5g6rA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5G6S_G_RAUG400_1
(IMINE REDUCTASE)		 5g6r IMINE REDUCTASE
(Aspergillus
oryzae) 		5 / 10 VAL A 121
LEU A 173
MET A 176
TYR A 177
PHE A 180
 NDP  A1000 ( 4.7A)
None
None
None
None
 0.67A 5g6sA-5g6rA:
37.9
5g6sG-5g6rA:
37.7		 5g6sA-5g6rA:
100.00
5g6sG-5g6rA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 5g6r IMINE REDUCTASE
(Aspergillus
oryzae) 		3 / 3 SER A 135
TYR A 134
TYR A 157
 None
 0.72A 5lakA-5g6rA:
undetectable
5lakI-5g6rA:
undetectable		 5lakA-5g6rA:
19.64
5lakI-5g6rA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 5g6r IMINE REDUCTASE
(Aspergillus
oryzae) 		3 / 3 SER A 135
TYR A 134
TYR A 157
 None
 0.75A 5lakC-5g6rA:
undetectable
5lakJ-5g6rA:
undetectable		 5lakC-5g6rA:
19.64
5lakJ-5g6rA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5g6r IMINE REDUCTASE
(Aspergillus
oryzae) 		5 / 11 ILE A  63
ILE A   5
VAL A  89
THR A  87
ILE A 145
 None
 1.09A 5lg3A-5g6rA:
undetectable		 5lg3A-5g6rA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5g6r IMINE REDUCTASE
(Aspergillus
oryzae) 		5 / 12 ILE A  63
ILE A   5
VAL A  89
THR A  87
ILE A 145
 None
 1.07A 5lg3E-5g6rA:
undetectable		 5lg3E-5g6rA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5g6r IMINE REDUCTASE
(Aspergillus
oryzae) 		5 / 10 ILE A  63
ILE A   5
VAL A  89
THR A  87
ILE A 145
 None
 1.07A 5lg3F-5g6rA:
undetectable		 5lg3F-5g6rA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5g6r IMINE REDUCTASE
(Aspergillus
oryzae) 		5 / 10 ILE A  63
ILE A   5
VAL A  89
THR A  87
ILE A 145
 None
 1.06A 5lg3G-5g6rA:
undetectable		 5lg3G-5g6rA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5g6r IMINE REDUCTASE
(Aspergillus
oryzae) 		5 / 10 ILE A  63
ILE A   5
VAL A  89
THR A  87
ILE A 145
 None
 1.05A 5lg3H-5g6rA:
undetectable		 5lg3H-5g6rA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5g6r IMINE REDUCTASE
(Aspergillus
oryzae) 		5 / 12 ILE A  63
ILE A   5
VAL A  89
THR A  87
ILE A 145
 None
 1.11A 5lg3J-5g6rA:
undetectable		 5lg3J-5g6rA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 5g6r IMINE REDUCTASE
(Aspergillus
oryzae) 		4 / 7 ILE A  52
LEU A  66
GLY A   9
PHE A   8
 None
NDP  A1000 (-4.4A)
NDP  A1000 (-3.5A)
None
 0.87A 5nooA-5g6rA:
undetectable		 5nooA-5g6rA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5g6r IMINE REDUCTASE
(Aspergillus
oryzae) 		4 / 4 LEU A  80
LEU A  83
SER A 108
ALA A 111
 None
 1.06A 5uunA-5g6rA:
undetectable		 5uunA-5g6rA:
22.01