SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gad'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 5gad SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY
(Escherichia
coli) 		4 / 5 LEU l 448
LEU l 445
SER l 459
GLY l 454
 None
 0.57A 1a4lC-5gadl:
3.3		 1a4lC-5gadl:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 5gad SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY
(Escherichia
coli) 		5 / 12 LEU l 397
GLY l 329
ILE l 368
ILE l 380
ILE l 400
 None
 0.98A 2qakB-5gadl:
undetectable		 2qakB-5gadl:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5gad SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY
(Escherichia
coli) 		5 / 12 GLY l 329
THR l 307
ILE l 364
ALA l 361
ASP l 330
 None
MG  l1401 ( 3.1A)
None
G  1  54 ( 3.3A)
GNP  l1400 ( 4.7A)
 1.14A 3nvkI-5gadl:
undetectable		 3nvkI-5gadl:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 5gad SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY
(Escherichia
coli) 		5 / 12 GLY l 300
GLY l 385
ASP l 382
LEU l 387
VAL l 304
 None
GNP  l1400 ( 3.3A)
MG  l1401 ( 4.1A)
None
GNP  l1400 ( 4.1A)
 0.97A 4fr0A-5gadl:
undetectable		 4fr0A-5gadl:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 5gad SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY
(Escherichia
coli) 		3 / 3 THR l 356
ASP l 330
GLU l 396
 None
GNP  l1400 ( 4.7A)
None
 0.78A 5fa8A-5gadl:
undetectable		 5fa8A-5gadl:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5gad SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY
(Escherichia
coli) 		3 / 3 ARG l 374
PRO l 350
ASN l 348
 None
 1.05A 5jwaA-5gadl:
undetectable
5jwaH-5gadl:
undetectable		 5jwaA-5gadl:
21.51
5jwaH-5gadl:
21.51