SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gaf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5gaf SIGNAL RECOGNITION
PARTICLE PROTEIN
(Escherichia
coli) 		4 / 8 THR i 266
GLY i  87
ALA i 259
HIS i 264
 None
 0.81A 1c9sI-5gafi:
undetectable
1c9sJ-5gafi:
undetectable		 1c9sI-5gafi:
12.30
1c9sJ-5gafi:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5gaf SIGNAL RECOGNITION
PARTICLE PROTEIN
(Escherichia
coli) 		4 / 7 GLY i  87
ALA i 259
HIS i 264
THR i 266
 None
 0.84A 1c9sT-5gafi:
undetectable
1c9sU-5gafi:
undetectable		 1c9sT-5gafi:
12.30
1c9sU-5gafi:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5gaf SIGNAL RECOGNITION
PARTICLE PROTEIN
(Escherichia
coli) 		4 / 7 GLY i  87
ALA i 259
HIS i 264
THR i 266
 None
 0.85A 1gtfL-5gafi:
undetectable
1gtfM-5gafi:
undetectable		 1gtfL-5gafi:
12.30
1gtfM-5gafi:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5gaf SIGNAL RECOGNITION
PARTICLE PROTEIN
(Escherichia
coli) 		4 / 8 GLY i  87
ALA i 259
HIS i 264
THR i 266
 None
 0.85A 1gtfN-5gafi:
undetectable
1gtfO-5gafi:
undetectable		 1gtfN-5gafi:
12.30
1gtfO-5gafi:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 5gaf SIGNAL RECOGNITION
PARTICLE PROTEIN
(Escherichia
coli) 		5 / 12 GLY i 257
GLY i 256
VAL i 250
LEU i  82
LEU i 273
 None
 1.30A 1ya4B-5gafi:
2.9		 1ya4B-5gafi:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5gaf SIGNAL RECOGNITION
PARTICLE PROTEIN
(Escherichia
coli) 		3 / 3 VAL i 208
VAL i 135
SER i 162
 None
 0.62A 3n8xB-5gafi:
3.0		 3n8xB-5gafi:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5gaf SIGNAL RECOGNITION
PARTICLE PROTEIN
(Escherichia
coli) 		4 / 5 VAL i  27
ILE i  77
MET i 297
ARG i  21
 None
 1.48A 3pyyB-5gafi:
undetectable		 3pyyB-5gafi:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 5gaf SIGNAL RECOGNITION
PARTICLE PROTEIN
(Escherichia
coli) 		5 / 11 LEU i   9
THR i   6
GLU i  40
ALA i  37
VAL i  43
 None
 1.21A 4e0fA-5gafi:
undetectable		 4e0fA-5gafi:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 5gaf SIGNAL RECOGNITION
PARTICLE PROTEIN
(Escherichia
coli) 		5 / 9 THR i 266
VAL i 245
VAL i 221
PHE i 236
LEU i 242
 None
 1.35A 4wnvA-5gafi:
undetectable		 4wnvA-5gafi:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5gaf SIGNAL RECOGNITION
PARTICLE PROTEIN
(Escherichia
coli) 		4 / 8 THR i 266
GLY i  87
ALA i 259
HIS i 264
 None
 0.84A 5eezL-5gafi:
undetectable
5eezV-5gafi:
undetectable		 5eezL-5gafi:
12.30
5eezV-5gafi:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5gaf SIGNAL RECOGNITION
PARTICLE PROTEIN
(Escherichia
coli) 		4 / 8 THR i 266
GLY i  87
ALA i 259
HIS i 264
 None
 0.84A 5ef1L-5gafi:
undetectable
5ef1V-5gafi:
undetectable		 5ef1L-5gafi:
12.30
5ef1V-5gafi:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5gaf SIGNAL RECOGNITION
PARTICLE PROTEIN
(Escherichia
coli) 		4 / 8 THR i 266
GLY i  87
ALA i 259
HIS i 264
 None
 0.84A 5ef2L-5gafi:
undetectable
5ef2V-5gafi:
undetectable		 5ef2L-5gafi:
12.30
5ef2V-5gafi:
12.30