SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gam'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5gam PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 730
GLY A 727
LEU A 721
PRO A 169
ILE A 719
 None
None
None
None
C  U 111 ( 4.4A)
 1.26A 1zq9A-5gamA:
undetectable		 1zq9A-5gamA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 5gam PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 7 ALA A 164
TYR A 167
TYR A 556
HIS A 194
 None
 1.34A 2pncA-5gamA:
undetectable		 2pncA-5gamA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_B_CLUB809_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 5gam PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 164
TYR A 167
TYR A 556
HIS A 194
 None
 1.45A 2pncB-5gamA:
undetectable		 2pncB-5gamA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 5gam PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 506
LEU A 507
ALA A 502
PRO A 706
VAL A 710
 None
 1.22A 3cwkA-5gamA:
undetectable		 3cwkA-5gamA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 5gam PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 633
VAL A 637
PHE A 242
ASN A 596
TYR A 251
 None
 1.49A 3d4sA-5gamA:
undetectable		 3d4sA-5gamA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5gam PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 257
HIS A 254
VAL A 565
 None
 0.90A 3elzB-5gamA:
undetectable		 3elzB-5gamA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 5gam PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 567
ASP A 563
VAL A 189
ILE A 172
VAL A 191
 None
 0.97A 3so9B-5gamA:
undetectable		 3so9B-5gamA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 5gam PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 336
PHE A 352
PHE A 331
ILE A 346
GLY A 348
 None
G  U 104 ( 4.6A)
None
None
None
 1.11A 3t3rA-5gamA:
undetectable		 3t3rA-5gamA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5gam PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 346
GLY A 339
VAL A 385
SER A 381
 None
 0.93A 4a3uB-5gamA:
undetectable		 4a3uB-5gamA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5gam PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 665
THR A 664
ILE A 660
THR A 718
 None
 0.84A 4acaC-5gamA:
undetectable		 4acaC-5gamA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 5gam PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 198
MET A 578
LEU A 581
ILE A 726
LEU A 582
 None
 1.20A 4j24D-5gamA:
undetectable		 4j24D-5gamA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5gam PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 178
GLU A 184
GLU A 188
GLU A 204
 None
None
None
U  U  33 ( 4.9A)
 1.49A 4mi4A-5gamA:
undetectable		 4mi4A-5gamA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5gam PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 12 PRO A 206
GLU A 204
ALA A 567
GLY A 568
LEU A 571
 None
U  U  33 ( 4.9A)
None
None
None
 1.29A 4oadA-5gamA:
undetectable		 4oadA-5gamA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5gam PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 12 PRO A 206
ALA A 171
ALA A 567
GLY A 568
LEU A 571
 None
 1.06A 4oaeA-5gamA:
undetectable		 4oaeA-5gamA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 5gam PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 210
ASP A 498
ARG A 495
ARG A 207
 None
A  U  82 ( 3.9A)
C  U 112 ( 3.0A)
U  U  33 ( 3.2A)
 1.22A 4uhxA-5gamA:
undetectable		 4uhxA-5gamA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5gam PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 698
ASP A 651
HIS A 654
TYR A 655
ILE A 687
 None
 1.31A 4ypaD-5gamA:
undetectable		 4ypaD-5gamA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUQ_A_ACTA1278_0
(NAD(P)H
DEHYDROGENASE
[QUINONE] 1)		 5gam PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 146
SER A 196
GLN A 574
ILE A 199
 None
 1.08A 5fuqA-5gamA:
undetectable
5fuqB-5gamA:
undetectable		 5fuqA-5gamA:
16.45
5fuqB-5gamA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5gam PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 12 MET A 622
LEU A 175
LEU A 176
ILE A 719
LEU A 168
 None
None
None
C  U 111 ( 4.4A)
None
 1.11A 5gtrA-5gamA:
undetectable		 5gtrA-5gamA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 5gam PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 636
LEU A 712
TRP A 704
LEU A 657
ILE A 656
 None
 1.38A 5xprA-5gamA:
0.8		 5xprA-5gamA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5gam PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 593
ASN A 155
LEU A 588
 None
 0.64A 6exiD-5gamA:
undetectable		 6exiD-5gamA:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 5gam PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 717
PHE A 714
VAL A 710
LYS A 670
 U  U  85 ( 3.0A)
None
None
C  U 101 ( 2.8A)
 0.93A 6hu9S-5gamA:
undetectable
6hu9q-5gamA:
undetectable		 6hu9S-5gamA:
9.50
6hu9q-5gamA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 5gam PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		6 / 11 GLY A 575
LEU A 165
ALA A 164
ALA A 198
PHE A 161
HIS A 146
 None
 1.44A 6qgbA-5gamA:
undetectable		 6qgbA-5gamA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_B_BEZB802_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 5gam PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 575
LEU A 165
ALA A 164
PHE A 161
HIS A 146
 None
 1.06A 6qgbB-5gamA:
undetectable		 6qgbB-5gamA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_D_BEZD701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 5gam PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 575
LEU A 165
ALA A 164
PHE A 161
HIS A 146
 None
 1.05A 6qgbD-5gamA:
undetectable		 6qgbD-5gamA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 5gam PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 575
LEU A 165
ALA A 164
PHE A 161
HIS A 146
 None
 1.04A 6qgbE-5gamA:
undetectable		 6qgbE-5gamA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 5gam PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 165
ALA A 164
ALA A 198
PHE A 161
HIS A 146
 None
 1.46A 6qgbE-5gamA:
undetectable		 6qgbE-5gamA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_F_BEZF701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 5gam PRE-MRNA-SPLICING
FACTOR 8
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 575
LEU A 165
ALA A 164
PHE A 161
HIS A 146
 None
 1.08A 6qgbF-5gamA:
undetectable		 6qgbF-5gamA:
19.53