SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gan'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 5gan PRE-MRNA-PROCESSING
FACTOR 31
(Saccharomyces
cerevisiae) 		3 / 3 GLN F 292
HIS F 299
PRO F 295
 None
 0.97A 1d8cA-5ganF:
undetectable		 1d8cA-5ganF:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5gan SPLICEOSOMAL PROTEIN
DIB1
(Saccharomyces
cerevisiae) 		5 / 11 LEU D 103
VAL D  82
MET D 113
LEU D  46
HIS D 139
 None
 1.30A 1kt6A-5ganD:
undetectable		 1kt6A-5ganD:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5gan SPLICEOSOMAL PROTEIN
DIB1
(Saccharomyces
cerevisiae) 		5 / 12 ILE D  59
VAL D  28
ILE D 116
VAL D  53
LEU D  26
 None
 1.14A 1z9hD-5ganD:
undetectable		 1z9hD-5ganD:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_1
(GAG-POL POLYPROTEIN)		 5gan PRE-MRNA-PROCESSING
FACTOR 31
(Saccharomyces
cerevisiae) 		5 / 12 GLY F 247
ILE F 222
GLY F 215
ILE F 214
ILE F 225
 None
 0.86A 2b60A-5ganF:
undetectable		 2b60A-5ganF:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 5gan PRE-MRNA-PROCESSING
FACTOR 31
(Saccharomyces
cerevisiae) 		5 / 11 GLY F 247
ILE F 222
GLY F 215
ILE F 214
ILE F 225
 None
 0.92A 2b60B-5ganF:
undetectable		 2b60B-5ganF:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5gan SPLICEOSOMAL PROTEIN
DIB1
(Saccharomyces
cerevisiae) 		3 / 3 ASP D  94
ASP D 136
ASN D  99
 U  W  32 ( 4.4A)
None
None
 0.40A 2bm9D-5ganD:
undetectable		 2bm9D-5ganD:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 5gan PRE-MRNA-PROCESSING
FACTOR 31
(Saccharomyces
cerevisiae) 		5 / 12 GLY F 247
ILE F 222
GLY F 215
ILE F 214
ILE F 225
 None
 0.80A 2hs1A-5ganF:
undetectable		 2hs1A-5ganF:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5gan PRE-MRNA-PROCESSING
FACTOR 31
(Saccharomyces
cerevisiae) 		4 / 6 TYR F 120
TYR F 137
GLN F 136
ILE F 131
 None
 1.37A 2pgzD-5ganF:
undetectable
2pgzE-5ganF:
undetectable		 2pgzD-5ganF:
19.72
2pgzE-5ganF:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 5gan PRE-MRNA-PROCESSING
FACTOR 31
(Saccharomyces
cerevisiae) 		4 / 6 ILE F 214
PRO F 134
SER F 138
MET F 112
 None
 1.14A 2qd3B-5ganF:
undetectable		 2qd3B-5ganF:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_1
(PROTEASE RETROPEPSIN)		 5gan PRE-MRNA-PROCESSING
FACTOR 31
(Saccharomyces
cerevisiae) 		5 / 12 GLY F 247
ILE F 222
GLY F 215
ILE F 214
ILE F 225
 None
 0.70A 2rkfA-5ganF:
undetectable		 2rkfA-5ganF:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_2
(PROTEASE RETROPEPSIN)		 5gan PRE-MRNA-PROCESSING
FACTOR 31
(Saccharomyces
cerevisiae) 		5 / 12 GLY F 247
ILE F 222
GLY F 215
ILE F 214
ILE F 225
 None
 0.82A 2rkgB-5ganF:
undetectable		 2rkgB-5ganF:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 5gan PRE-MRNA-PROCESSING
FACTOR 31
(Saccharomyces
cerevisiae) 		4 / 8 ILE F 214
LEU F  84
LEU F  80
PHE F  54
 None
 0.90A 2vctC-5ganF:
undetectable		 2vctC-5ganF:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 5gan SPLICEOSOMAL PROTEIN
DIB1
(Saccharomyces
cerevisiae) 		4 / 8 LEU D 103
LEU D  45
LEU D 117
ARG D  30
 None
 1.17A 2xn3A-5ganD:
undetectable
2xn3B-5ganD:
undetectable		 2xn3A-5ganD:
18.15
2xn3B-5ganD:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5gan PRE-MRNA-PROCESSING
FACTOR 31
(Saccharomyces
cerevisiae) 		4 / 7 PRO F  48
SER F  50
ILE F 101
PRO F  43
 None
 0.91A 2y7kA-5ganF:
undetectable		 2y7kA-5ganF:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 5gan PRE-MRNA-PROCESSING
FACTOR 31
(Saccharomyces
cerevisiae) 		5 / 12 ILE F 101
ILE F 105
ILE F 214
ILE F  46
PHE F  98
 None
 1.03A 2ygoA-5ganF:
undetectable		 2ygoA-5ganF:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5gan SPLICEOSOMAL PROTEIN
DIB1
(Saccharomyces
cerevisiae) 		5 / 11 LEU D 103
VAL D  82
MET D 113
LEU D  46
HIS D 139
 None
 1.30A 3bszE-5ganD:
undetectable		 3bszE-5ganD:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 5gan SPLICEOSOMAL PROTEIN
DIB1
(Saccharomyces
cerevisiae) 		3 / 3 PHE D  84
CYH D  93
PHE D  95
 None
 1.12A 3cr5X-5ganD:
undetectable		 3cr5X-5ganD:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_2
(PROTEASE)		 5gan PRE-MRNA-PROCESSING
FACTOR 31
(Saccharomyces
cerevisiae) 		5 / 11 GLY F 247
ILE F 222
GLY F 215
ILE F 214
ILE F 225
 None
 0.88A 3s45B-5ganF:
undetectable		 3s45B-5ganF:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 5gan SPLICEOSOMAL PROTEIN
DIB1
(Saccharomyces
cerevisiae) 		4 / 4 ILE D  49
VAL D  58
VAL D  53
ARG D  52
 None
 1.01A 4m6tA-5ganD:
undetectable		 4m6tA-5ganD:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5gan SPLICEOSOMAL PROTEIN
DIB1
(Saccharomyces
cerevisiae) 		4 / 5 TYR D 137
LEU D   6
THR D  81
MET D  83
 None
 1.48A 4mbsB-5ganD:
undetectable		 4mbsB-5ganD:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 5gan PRE-MRNA-PROCESSING
FACTOR 31
(Saccharomyces
cerevisiae) 		5 / 12 GLY F 247
ILE F 222
GLY F 215
ILE F 214
ILE F 225
 None
 0.72A 5e5jA-5ganF:
undetectable		 5e5jA-5ganF:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_2
(HIV-1 PROTEASE)		 5gan PRE-MRNA-PROCESSING
FACTOR 31
(Saccharomyces
cerevisiae) 		5 / 12 GLY F 247
ILE F 222
GLY F 215
ILE F 214
ILE F 225
 None
 0.86A 5e5kB-5ganF:
undetectable		 5e5kB-5ganF:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 5gan PRE-MRNA-PROCESSING
FACTOR 31
(Saccharomyces
cerevisiae) 		5 / 12 GLY F 247
ILE F 222
GLY F 215
ILE F 214
ILE F 225
 None
 0.87A 5t8hA-5ganF:
undetectable		 5t8hA-5ganF:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 5gan PRE-MRNA-PROCESSING
FACTOR 31
(Saccharomyces
cerevisiae) 		5 / 10 ILE F 105
LEU F  47
LEU F  80
PHE F  54
SER F  50
 None
 1.18A 5tixB-5ganF:
undetectable		 5tixB-5ganF:
18.45