SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gha'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 5gha SULFUR CARRIER TTUB
(Thermus
thermophilus) 		4 / 5 LEU E  46
LEU E  25
SER E  60
LEU E   7
 None
 1.00A 1a4lC-5ghaE:
undetectable		 1a4lC-5ghaE:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5gha SULFUR CARRIER TTUB
(Thermus
thermophilus) 		4 / 8 LEU E  44
ALA E  37
VAL E  58
VAL E   3
 None
EDO  E 101 (-3.3A)
None
None
 0.71A 1epbB-5ghaE:
undetectable		 1epbB-5ghaE:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 5gha SULFUR TRANSFERASE
TTUA
(Thermus
thermophilus) 		5 / 9 ALA A 236
GLU A 235
LEU A 232
LEU A 231
LEU A 171
 None
 1.50A 1ereB-5ghaA:
undetectable		 1ereB-5ghaA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 5gha SULFUR TRANSFERASE
TTUA
(Thermus
thermophilus) 		5 / 9 ALA A 236
GLU A 235
LEU A 232
LEU A 231
LEU A 171
 None
 1.49A 1ereC-5ghaA:
undetectable		 1ereC-5ghaA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 5gha SULFUR TRANSFERASE
TTUA
(Thermus
thermophilus) 		5 / 10 ALA A 236
GLU A 235
LEU A 232
LEU A 231
LEU A 171
 None
 1.48A 1pcgB-5ghaA:
undetectable		 1pcgB-5ghaA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 5gha SULFUR CARRIER TTUB
SULFUR TRANSFERASE
TTUA
(Thermus
thermophilus) 		4 / 5 ASP E  48
GLU A  13
LEU E  43
LEU E  44
 None
 1.01A 1u18B-5ghaE:
undetectable		 1u18B-5ghaE:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 5gha SULFUR TRANSFERASE
TTUA
(Thermus
thermophilus) 		4 / 7 ALA A  37
ARG A  36
TYR A 209
PHE A 201
 None
 1.08A 2ajvH-5ghaA:
undetectable
2ajvL-5ghaA:
undetectable		 2ajvH-5ghaA:
18.87
2ajvL-5ghaA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5gha SULFUR TRANSFERASE
TTUA
(Thermus
thermophilus) 		4 / 7 VAL A  12
SER A 208
LEU A  19
PHE A  30
 None
 1.01A 2f78A-5ghaA:
undetectable		 2f78A-5ghaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5gha SULFUR TRANSFERASE
TTUA
(Thermus
thermophilus) 		4 / 7 VAL A  12
SER A 208
LEU A  19
PHE A  30
 None
 1.00A 2f78B-5ghaA:
undetectable		 2f78B-5ghaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5gha SULFUR TRANSFERASE
TTUA
(Thermus
thermophilus) 		4 / 6 VAL A  12
SER A 208
LEU A  19
PHE A  30
 None
 1.10A 2f8dA-5ghaA:
undetectable		 2f8dA-5ghaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 5gha SULFUR TRANSFERASE
TTUA
(Thermus
thermophilus) 		5 / 11 SER A  55
SER A  60
THR A 155
GLY A 156
HIS A 157
 None
 0.48A 2hmaA-5ghaA:
9.9		 2hmaA-5ghaA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 5gha SULFUR TRANSFERASE
TTUA
(Thermus
thermophilus) 		3 / 3 TYR A 209
VAL A  66
THR A 210
 None
 0.77A 2ygnA-5ghaA:
undetectable		 2ygnA-5ghaA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_B_ESTB600_1
(ESTROGEN RECEPTOR)		 5gha SULFUR TRANSFERASE
TTUA
(Thermus
thermophilus) 		5 / 10 ALA A 236
GLU A 235
LEU A 232
LEU A 231
LEU A 171
 None
 1.45A 3uudB-5ghaA:
undetectable		 3uudB-5ghaA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5gha SULFUR TRANSFERASE
TTUA
(Thermus
thermophilus) 		5 / 12 ALA A 154
ALA A  74
VAL A  50
ASP A  65
ALA A  62
 None
 1.18A 4df3A-5ghaA:
undetectable		 4df3A-5ghaA:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5gha SULFUR TRANSFERASE
TTUA
(Thermus
thermophilus) 		5 / 12 ALA A 154
ALA A  74
VAL A  50
ASP A  65
ALA A  62
 None
 1.16A 4df3B-5ghaA:
3.7		 4df3B-5ghaA:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 5gha SULFUR CARRIER TTUB
SULFUR TRANSFERASE
TTUA
(Thermus
thermophilus) 		5 / 12 GLU E  33
GLY A 246
TYR A  26
SER A 208
VAL E  36
 None
None
None
None
EDO  E 101 (-4.1A)
 1.37A 4ffwA-5ghaE:
undetectable		 4ffwA-5ghaE:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5gha SULFUR CARRIER TTUB
SULFUR TRANSFERASE
TTUA
(Thermus
thermophilus) 		5 / 12 GLU E  33
GLY A 246
TYR A  26
SER A 208
VAL E  36
 None
None
None
None
EDO  E 101 (-4.1A)
 1.34A 4ffwB-5ghaE:
undetectable		 4ffwB-5ghaE:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5gha SULFUR CARRIER TTUB
SULFUR TRANSFERASE
TTUA
(Thermus
thermophilus) 		5 / 12 GLU E  33
GLY A 246
TYR A  26
SER A 208
VAL E  36
 None
None
None
None
EDO  E 101 (-4.1A)
 1.48A 4ffwB-5ghaE:
undetectable		 4ffwB-5ghaE:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 5gha SULFUR TRANSFERASE
TTUA
SULFUR CARRIER TTUB
(Thermus
thermophilus;
Thermus
thermophilus) 		4 / 5 VAL E  35
ARG A 204
GLU E  33
LEU E  46
 EDO  E 101 (-4.8A)
None
None
None
 1.17A 4hojA-5ghaE:
undetectable		 4hojA-5ghaE:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 5gha SULFUR TRANSFERASE
TTUA
(Thermus
thermophilus) 		4 / 7 VAL A  66
ARG A  69
TYR A 209
ARG A 213
 None
 1.14A 4ijiH-5ghaA:
undetectable		 4ijiH-5ghaA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5gha SULFUR TRANSFERASE
TTUA
(Thermus
thermophilus) 		4 / 7 TYR A 114
VAL A 108
ILE A 141
LEU A 121
 None
 1.24A 4xo7B-5ghaA:
undetectable		 4xo7B-5ghaA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5gha SULFUR TRANSFERASE
TTUA
(Thermus
thermophilus) 		5 / 12 VAL A 108
ASP A 109
PHE A 288
GLY A 117
LEU A 121
 None
 1.29A 5ogcB-5ghaA:
undetectable		 5ogcB-5ghaA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5gha SULFUR TRANSFERASE
TTUA
(Thermus
thermophilus) 		3 / 3 VAL A  50
TYR A  72
GLN A  73
 None
 0.75A 5qgrA-5ghaA:
undetectable		 5qgrA-5ghaA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5gha SULFUR TRANSFERASE
TTUA
(Thermus
thermophilus) 		3 / 3 VAL A  50
TYR A  72
GLN A  73
 None
 0.75A 5qgtA-5ghaA:
undetectable		 5qgtA-5ghaA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5gha SULFUR TRANSFERASE
TTUA
(Thermus
thermophilus) 		5 / 12 LEU A  63
GLY A  56
LEU A  67
SER A  68
VAL A  52
 None
 0.89A 5twjA-5ghaA:
undetectable		 5twjA-5ghaA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5gha SULFUR TRANSFERASE
TTUA
(Thermus
thermophilus) 		5 / 10 LEU A  63
GLY A  56
LEU A  67
SER A  68
VAL A  52
 None
 0.91A 5twjB-5ghaA:
undetectable		 5twjB-5ghaA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5gha SULFUR TRANSFERASE
TTUA
(Thermus
thermophilus) 		5 / 10 ALA A 236
GLU A 235
LEU A 232
LEU A 231
LEU A 171
 None
 1.48A 5wgqB-5ghaA:
undetectable		 5wgqB-5ghaA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 5gha SULFUR TRANSFERASE
TTUA
(Thermus
thermophilus) 		5 / 12 LEU A 304
LEU A 121
GLY A 117
PHE A 116
ALA A 129
 None
 1.43A 6qyaB-5ghaA:
undetectable		 6qyaB-5ghaA:
21.13