SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ghs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 5ghs SSDNA-SPECIFIC
EXONUCLEASE
(Thermococcus
kodakarensis) 		4 / 7 GLY A 314
TYR A 325
ALA A 316
GLU A 322
 None
 0.88A 1dmaA-5ghsA:
undetectable		 1dmaA-5ghsA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 5ghs SSDNA-SPECIFIC
EXONUCLEASE
(Thermococcus
kodakarensis) 		4 / 4 ARG A 296
ALA A 299
ALA A 163
GLU A 169
 None
 0.91A 1e7bA-5ghsA:
undetectable		 1e7bA-5ghsA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 5ghs SSDNA-SPECIFIC
EXONUCLEASE
(Thermococcus
kodakarensis) 		4 / 4 ARG A 296
ALA A 299
ALA A 163
GLU A 169
 None
 0.87A 1e7bB-5ghsA:
undetectable		 1e7bB-5ghsA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 5ghs SSDNA-SPECIFIC
EXONUCLEASE
(Thermococcus
kodakarensis) 		4 / 6 HIS A  25
ILE A  78
ALA A  47
VAL A  80
 None
 0.91A 1hk1A-5ghsA:
undetectable		 1hk1A-5ghsA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ghs SSDNA-SPECIFIC
EXONUCLEASE
(Thermococcus
kodakarensis) 		5 / 12 ASP A 279
ASP A 171
LEU A 179
GLY A 176
HIS A 175
 None
 1.17A 1v8bD-5ghsA:
undetectable		 1v8bD-5ghsA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 5ghs SSDNA-SPECIFIC
EXONUCLEASE
(Thermococcus
kodakarensis) 		4 / 7 SER A 136
ASP A  36
SER A 138
ASN A 178
 None
 1.14A 2cmlA-5ghsA:
undetectable		 2cmlA-5ghsA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 5ghs SSDNA-SPECIFIC
EXONUCLEASE
(Thermococcus
kodakarensis) 		5 / 12 LEU A 319
VAL A 158
ASN A 152
MET A 148
ALA A 145
 None
 1.32A 3nuvA-5ghsA:
undetectable		 3nuvA-5ghsA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 5ghs SSDNA-SPECIFIC
EXONUCLEASE
(Thermococcus
kodakarensis) 		5 / 12 GLY A 435
GLU A 436
GLY A 407
ALA A 444
PHE A 456
 None
 1.22A 3qowA-5ghsA:
2.1		 3qowA-5ghsA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 5ghs SSDNA-SPECIFIC
EXONUCLEASE
(Thermococcus
kodakarensis) 		5 / 10 PHE A 448
GLY A 437
VAL A 361
PHE A 460
PHE A 456
 None
 1.42A 3r6wA-5ghsA:
2.9
3r6wB-5ghsA:
3.1		 3r6wA-5ghsA:
20.25
3r6wB-5ghsA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 5ghs SSDNA-SPECIFIC
EXONUCLEASE
(Thermococcus
kodakarensis) 		3 / 3 LEU A  23
HIS A  20
MET A  19
 None
 0.85A 3thrD-5ghsA:
undetectable		 3thrD-5ghsA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 5ghs SSDNA-SPECIFIC
EXONUCLEASE
(Thermococcus
kodakarensis) 		5 / 9 LEU A  91
GLU A  93
PHE A  81
GLU A 110
VAL A 101
 None
 1.23A 3tmzA-5ghsA:
undetectable		 3tmzA-5ghsA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQE_B_DXCB1079_0
(PROTEIN PRGI, CELL
INVASION PROTEIN
SIPD)		 5ghs SSDNA-SPECIFIC
EXONUCLEASE
(Thermococcus
kodakarensis) 		5 / 11 LYS A 252
GLN A 209
LEU A 207
TYR A 213
ARG A 202
 None
 1.42A 3zqeA-5ghsA:
undetectable
3zqeB-5ghsA:
0.0		 3zqeA-5ghsA:
21.02
3zqeB-5ghsA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 5ghs SSDNA-SPECIFIC
EXONUCLEASE
(Thermococcus
kodakarensis) 		4 / 6 GLY A 314
TYR A 325
ALA A 316
GLU A 322
 None
 1.00A 4ae1A-5ghsA:
undetectable		 4ae1A-5ghsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5ghs SSDNA-SPECIFIC
EXONUCLEASE
(Thermococcus
kodakarensis) 		4 / 8 ASP A  83
ASP A 105
GLU A 169
ASP A  34
 None
 1.00A 4feuD-5ghsA:
undetectable		 4feuD-5ghsA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 5ghs SSDNA-SPECIFIC
EXONUCLEASE
(Thermococcus
kodakarensis) 		4 / 6 ALA A 310
ASN A 309
LEU A 308
GLU A 400
 None
 1.00A 4g24A-5ghsA:
undetectable		 4g24A-5ghsA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5ghs SSDNA-SPECIFIC
EXONUCLEASE
(Thermococcus
kodakarensis) 		5 / 9 ALA A 129
VAL A 144
GLY A 139
SER A  86
VAL A 122
 None
 1.31A 4r20B-5ghsA:
undetectable		 4r20B-5ghsA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5ghs SSDNA-SPECIFIC
EXONUCLEASE
(Thermococcus
kodakarensis) 		5 / 11 ALA A 235
LEU A 233
LEU A 211
LEU A 259
LEU A 255
 None
 0.87A 4wg0C-5ghsA:
undetectable
4wg0D-5ghsA:
undetectable
4wg0E-5ghsA:
undetectable		 4wg0C-5ghsA:
3.00
4wg0D-5ghsA:
3.00
4wg0E-5ghsA:
3.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5ghs SSDNA-SPECIFIC
EXONUCLEASE
(Thermococcus
kodakarensis) 		5 / 11 ALA A 235
LEU A 233
LEU A 211
LEU A 259
LEU A 255
 None
 0.87A 4wg0E-5ghsA:
undetectable
4wg0F-5ghsA:
undetectable
4wg0G-5ghsA:
undetectable		 4wg0E-5ghsA:
3.00
4wg0F-5ghsA:
3.00
4wg0G-5ghsA:
3.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 5ghs SSDNA-SPECIFIC
EXONUCLEASE
(Thermococcus
kodakarensis) 		5 / 12 ALA A 304
THR A 300
LEU A 332
GLY A 314
ALA A 310
 None
 0.99A 4ypmA-5ghsA:
undetectable		 4ypmA-5ghsA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 5ghs SSDNA-SPECIFIC
EXONUCLEASE
(Thermococcus
kodakarensis) 		5 / 9 LEU A 302
LEU A 313
GLY A 314
LEU A 332
ALA A 328
 None
 0.95A 5dqfA-5ghsA:
undetectable		 5dqfA-5ghsA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 5ghs SSDNA-SPECIFIC
EXONUCLEASE
(Thermococcus
kodakarensis) 		3 / 3 ILE A 219
PRO A 220
ILE A 222
 None
 0.39A 5hw8F-5ghsA:
undetectable		 5hw8F-5ghsA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5ghs SSDNA-SPECIFIC
EXONUCLEASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A  21
ALA A 104
VAL A 102
GLY A  37
THR A  39
 None
 1.13A 5igiA-5ghsA:
undetectable		 5igiA-5ghsA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ghs SSDNA-SPECIFIC
EXONUCLEASE
(Thermococcus
kodakarensis) 		5 / 12 ASP A 279
ASP A 171
LEU A 179
GLY A 176
HIS A 175
 None
 1.15A 5m5kA-5ghsA:
2.5		 5m5kA-5ghsA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ghs SSDNA-SPECIFIC
EXONUCLEASE
(Thermococcus
kodakarensis) 		5 / 12 ASP A 279
ASP A 171
LEU A 179
GLY A 176
HIS A 175
 None
 1.18A 5m66C-5ghsA:
2.6		 5m66C-5ghsA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ghs SSDNA-SPECIFIC
EXONUCLEASE
(Thermococcus
kodakarensis) 		5 / 12 ASP A 279
ASP A 171
LEU A 179
GLY A 176
HIS A 175
 None
 1.12A 5m66D-5ghsA:
undetectable		 5m66D-5ghsA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5ghs SSDNA-SPECIFIC
EXONUCLEASE
(Thermococcus
kodakarensis) 		3 / 3 GLU A 323
TYR A 325
ARG A 292
 None
 0.81A 5uunA-5ghsA:
2.2		 5uunA-5ghsA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5ghs SSDNA-SPECIFIC
EXONUCLEASE
(Thermococcus
kodakarensis) 		3 / 3 GLU A 323
TYR A 325
ARG A 292
 None
 0.72A 5uunB-5ghsA:
undetectable		 5uunB-5ghsA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 5ghs SSDNA-SPECIFIC
EXONUCLEASE
(Thermococcus
kodakarensis) 		5 / 11 GLY A 162
ASP A  36
ALA A 163
ALA A 159
ILE A  43
 None
 1.18A 5yk2A-5ghsA:
undetectable		 5yk2A-5ghsA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ghs SSDNA-SPECIFIC
EXONUCLEASE
(Thermococcus
kodakarensis) 		3 / 3 TYR A  79
ARG A  28
THR A  26
 None
 0.97A 5z84J-5ghsA:
undetectable		 5z84J-5ghsA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ghs SSDNA-SPECIFIC
EXONUCLEASE
(Thermococcus
kodakarensis) 		4 / 5 PHE A  98
TYR A  79
ARG A  28
THR A  26
 None
 1.08A 5z84N-5ghsA:
undetectable
5z84W-5ghsA:
undetectable		 5z84N-5ghsA:
19.85
5z84W-5ghsA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 5ghs SSDNA-SPECIFIC
EXONUCLEASE
(Thermococcus
kodakarensis) 		5 / 12 PHE A   6
GLY A 137
GLY A 139
ALA A 159
ASP A  34
 None
 1.19A 6b3aA-5ghsA:
2.3		 6b3aA-5ghsA:
23.40