SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gin'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)
5gin C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT

(Sulfolobus
solfataricus)
4 / 8 LEU A   6
ALA A  15
VAL A  23
VAL A  58
None
0.86A 1epbB-5ginA:
undetectable
1epbB-5ginA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5gin 50S RIBOSOMAL
PROTEIN L7AE

(Sulfolobus
solfataricus)
5 / 11 HIS C  68
THR C  42
THR C  43
SER C 101
ALA C 100
None
None
None
None
U  H  11 ( 3.7A)
1.17A 1gtnM-5ginC:
undetectable
1gtnN-5ginC:
undetectable
1gtnM-5ginC:
22.31
1gtnN-5ginC:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5gin 50S RIBOSOMAL
PROTEIN L7AE

(Sulfolobus
solfataricus)
5 / 10 HIS C  68
THR C  42
THR C  43
SER C 101
ALA C 100
None
None
None
None
U  H  11 ( 3.7A)
1.23A 1gtnO-5ginC:
undetectable
1gtnP-5ginC:
undetectable
1gtnO-5ginC:
22.31
1gtnP-5ginC:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5gin 50S RIBOSOMAL
PROTEIN L7AE

(Sulfolobus
solfataricus)
5 / 9 HIS C  68
THR C  42
THR C  43
SER C 101
ALA C 100
None
None
None
None
U  H  11 ( 3.7A)
1.21A 1gtnQ-5ginC:
undetectable
1gtnR-5ginC:
undetectable
1gtnQ-5ginC:
22.31
1gtnR-5ginC:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
5 / 12 LEU E 117
ALA E 121
SER E  95
TYR E 105
GLY E 106
None
1.09A 1kglA-5ginE:
undetectable
1kglA-5ginE:
16.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
8 / 12 LYS E  60
TYR E  82
GLY E  84
SER E 110
ALA E 134
ASP E 153
ILE E 154
GLN E 156
U  I   4 ( 3.9A)
SAH  E 301 (-4.9A)
SAH  E 301 (-3.8A)
A  G  24 ( 2.5A)
SAH  E 301 (-3.6A)
SAH  E 301 (-3.7A)
SAH  E 301 ( 4.4A)
SAH  E 301 (-3.8A)
0.82A 1nt2A-5ginE:
31.6
1nt2A-5ginE:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
9 / 12 TYR E  82
GLY E  84
ALA E  86
SER E  87
THR E  90
ALA E 134
ASP E 153
ILE E 154
GLN E 156
SAH  E 301 (-4.9A)
SAH  E 301 (-3.8A)
SAH  E 301 ( 3.7A)
A  I   6 ( 3.2A)
SAH  E 301 (-3.2A)
SAH  E 301 (-3.6A)
SAH  E 301 (-3.7A)
SAH  E 301 ( 4.4A)
SAH  E 301 (-3.8A)
0.74A 1nt2A-5ginE:
31.6
1nt2A-5ginE:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
9 / 12 TYR E  82
GLY E  84
ALA E  86
THR E  90
SER E 110
ALA E 134
ASP E 153
ILE E 154
GLN E 156
SAH  E 301 (-4.9A)
SAH  E 301 (-3.8A)
SAH  E 301 ( 3.7A)
SAH  E 301 (-3.2A)
A  G  24 ( 2.5A)
SAH  E 301 (-3.6A)
SAH  E 301 (-3.7A)
SAH  E 301 ( 4.4A)
SAH  E 301 (-3.8A)
0.58A 1nt2A-5ginE:
31.6
1nt2A-5ginE:
41.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
5 / 12 ILE E 214
ILE E  74
LEU E  61
ILE E  65
ILE E  97
None
1.05A 1oipA-5ginE:
undetectable
1oipA-5ginE:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
5 / 10 GLY E  84
VAL E 107
LEU E  81
LEU E 150
ALA E 134
SAH  E 301 (-3.8A)
None
None
None
SAH  E 301 (-3.6A)
1.27A 1pbcA-5ginE:
3.7
1pbcA-5ginE:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_T_TRPT81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5gin 50S RIBOSOMAL
PROTEIN L7AE

(Sulfolobus
solfataricus)
5 / 10 HIS C  68
THR C  42
THR C  43
SER C 101
ALA C 100
None
None
None
None
U  H  11 ( 3.7A)
1.19A 1utdT-5ginC:
undetectable
1utdU-5ginC:
undetectable
1utdT-5ginC:
22.31
1utdU-5ginC:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)
5gin C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT
FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
5 / 5 ALA E 167
TYR A  86
ALA E 163
TYR E 165
GLN E 138
None
1.48A 1xl6A-5ginE:
undetectable
1xl6B-5ginE:
undetectable
1xl6A-5ginE:
21.04
1xl6B-5ginE:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
3 / 3 GLY E  84
GLU E 108
ASP E 153
SAH  E 301 (-3.8A)
SAH  E 301 (-3.0A)
SAH  E 301 (-3.7A)
0.42A 2b25B-5ginE:
14.5
2b25B-5ginE:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)
5gin 50S RIBOSOMAL
PROTEIN L7AE
C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT

(Sulfolobus
solfataricus)
4 / 7 ARG A 350
GLU C  63
ALA C 100
ALA C  57
None
None
U  H  11 ( 3.7A)
None
1.04A 2ejfA-5ginA:
undetectable
2ejfA-5ginA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)
5gin C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT

(Sulfolobus
solfataricus)
4 / 6 ARG A 248
GLU A 255
PRO A 271
ALA A 272
None
1.47A 2ejfB-5ginA:
undetectable
2ejfB-5ginA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
5gin C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT
FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
4 / 5 LEU A 122
VAL E 152
LEU E 150
ARG E 135
None
None
None
SAH  E 301 ( 4.8A)
1.08A 2oiqA-5ginA:
undetectable
2oiqA-5ginA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
5gin C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT

(Sulfolobus
solfataricus)
4 / 7 TYR A 165
PHE A 169
LEU A 214
ALA A 217
None
1.02A 2vcvA-5ginA:
undetectable
2vcvA-5ginA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)
5gin C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT
FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
4 / 4 ALA E 167
TYR A  86
ALA E 163
TYR E 165
None
1.20A 2wlkA-5ginE:
undetectable
2wlkB-5ginE:
undetectable
2wlkA-5ginE:
21.04
2wlkB-5ginE:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)
5gin C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT

(Sulfolobus
solfataricus)
4 / 5 VAL A  14
TYR A  25
ASP A 103
SER A  96
None
1.31A 2x45A-5ginA:
undetectable
2x45A-5ginA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)
5gin C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT

(Sulfolobus
solfataricus)
4 / 5 VAL A  14
TYR A  25
ASP A 103
SER A  96
None
1.28A 2x45C-5ginA:
undetectable
2x45C-5ginA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)
5gin C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT

(Sulfolobus
solfataricus)
4 / 6 GLU A 255
ALA A 140
PRO A 271
ALA A 275
None
1.16A 2zgwB-5ginA:
undetectable
2zgwB-5ginA:
22.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
6 / 11 LYS E  60
THR E  90
PHE E 109
ASP E 133
ALA E 134
ILE E 154
U  I   4 ( 3.9A)
SAH  E 301 (-3.2A)
SAH  E 301 (-3.6A)
SAH  E 301 (-3.5A)
SAH  E 301 (-3.6A)
SAH  E 301 ( 4.4A)
1.01A 3id5B-5ginE:
34.9
3id5B-5ginE:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
10 / 11 LYS E  60
TYR E  82
GLY E  84
THR E  90
GLU E 108
ASP E 133
ALA E 134
ASP E 153
ILE E 154
GLN E 156
U  I   4 ( 3.9A)
SAH  E 301 (-4.9A)
SAH  E 301 (-3.8A)
SAH  E 301 (-3.2A)
SAH  E 301 (-3.0A)
SAH  E 301 (-3.5A)
SAH  E 301 (-3.6A)
SAH  E 301 (-3.7A)
SAH  E 301 ( 4.4A)
SAH  E 301 (-3.8A)
0.67A 3id5B-5ginE:
34.9
3id5B-5ginE:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
6 / 11 TYR E 151
THR E  90
ALA E 134
ASP E 153
ILE E 154
GLN E 156
None
SAH  E 301 (-3.2A)
SAH  E 301 (-3.6A)
SAH  E 301 (-3.7A)
SAH  E 301 ( 4.4A)
SAH  E 301 (-3.8A)
1.40A 3id5B-5ginE:
34.9
3id5B-5ginE:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
6 / 11 LYS E  60
THR E  90
PHE E 109
ASP E 133
ALA E 134
ILE E 154
U  I   4 ( 3.9A)
SAH  E 301 (-3.2A)
SAH  E 301 (-3.6A)
SAH  E 301 (-3.5A)
SAH  E 301 (-3.6A)
SAH  E 301 ( 4.4A)
1.01A 3id5F-5ginE:
34.9
3id5F-5ginE:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
10 / 11 LYS E  60
TYR E  82
GLY E  84
THR E  90
GLU E 108
ASP E 133
ALA E 134
ASP E 153
ILE E 154
GLN E 156
U  I   4 ( 3.9A)
SAH  E 301 (-4.9A)
SAH  E 301 (-3.8A)
SAH  E 301 (-3.2A)
SAH  E 301 (-3.0A)
SAH  E 301 (-3.5A)
SAH  E 301 (-3.6A)
SAH  E 301 (-3.7A)
SAH  E 301 ( 4.4A)
SAH  E 301 (-3.8A)
0.66A 3id5F-5ginE:
34.9
3id5F-5ginE:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
6 / 11 TYR E 151
THR E  90
ALA E 134
ASP E 153
ILE E 154
GLN E 156
None
SAH  E 301 (-3.2A)
SAH  E 301 (-3.6A)
SAH  E 301 (-3.7A)
SAH  E 301 ( 4.4A)
SAH  E 301 (-3.8A)
1.40A 3id5F-5ginE:
34.9
3id5F-5ginE:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
11 / 12 TYR E  82
GLY E  84
ALA E  86
THR E  90
GLU E 108
SER E 110
ASP E 133
ALA E 134
ASP E 153
ILE E 154
GLN E 156
SAH  E 301 (-4.9A)
SAH  E 301 (-3.8A)
SAH  E 301 ( 3.7A)
SAH  E 301 (-3.2A)
SAH  E 301 (-3.0A)
A  G  24 ( 2.5A)
SAH  E 301 (-3.5A)
SAH  E 301 (-3.6A)
SAH  E 301 (-3.7A)
SAH  E 301 ( 4.4A)
SAH  E 301 (-3.8A)
0.55A 3id6C-5ginE:
36.5
3id6C-5ginE:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
5 / 12 GLY E  84
GLY E  88
THR E  90
ASP E 133
ASP E 153
SAH  E 301 (-3.8A)
None
SAH  E 301 (-3.2A)
SAH  E 301 (-3.5A)
SAH  E 301 (-3.7A)
0.86A 3ihtA-5ginE:
10.8
3ihtA-5ginE:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)
5gin 50S RIBOSOMAL
PROTEIN L7AE
C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT

(Sulfolobus
solfataricus)
4 / 6 GLY C 126
GLN A  75
ARG A  80
ILE C 124
None
1.09A 3kvvA-5ginC:
undetectable
3kvvA-5ginC:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)
5gin 50S RIBOSOMAL
PROTEIN L7AE
C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT

(Sulfolobus
solfataricus)
4 / 6 GLY C 126
GLN A  75
ARG A  80
ILE C 124
None
1.10A 3kvvB-5ginC:
undetectable
3kvvB-5ginC:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)
5gin 50S RIBOSOMAL
PROTEIN L7AE
C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT

(Sulfolobus
solfataricus)
4 / 6 GLY C 126
GLN A  75
ARG A  80
ILE C 124
None
1.07A 3kvvC-5ginC:
undetectable
3kvvC-5ginC:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)
5gin 50S RIBOSOMAL
PROTEIN L7AE
C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT

(Sulfolobus
solfataricus)
4 / 6 GLY C 126
GLN A  75
ARG A  80
ILE C 124
None
1.10A 3kvvD-5ginC:
undetectable
3kvvD-5ginC:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)
5gin 50S RIBOSOMAL
PROTEIN L7AE
C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT

(Sulfolobus
solfataricus)
4 / 6 GLY C 126
GLN A  75
ARG A  80
ILE C 124
None
1.13A 3kvvE-5ginC:
undetectable
3kvvE-5ginC:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)
5gin 50S RIBOSOMAL
PROTEIN L7AE
C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT

(Sulfolobus
solfataricus)
4 / 6 GLY C 126
GLN A  75
ARG A  80
ILE C 124
None
1.15A 3kvvF-5ginC:
undetectable
3kvvF-5ginC:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
4 / 7 TYR E 230
SER E 206
ASN E 207
THR E 160
None
1.05A 3lm8B-5ginE:
2.1
3lm8D-5ginE:
2.3
3lm8B-5ginE:
22.05
3lm8D-5ginE:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
4 / 4 GLY E  84
GLU E 108
ASP E 133
ASP E 153
SAH  E 301 (-3.8A)
SAH  E 301 (-3.0A)
SAH  E 301 (-3.5A)
SAH  E 301 (-3.7A)
0.42A 3mb5A-5ginE:
17.3
3mb5A-5ginE:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
5 / 12 GLU E 108
PHE E 109
SER E 110
ASP E 133
ALA E 134
SAH  E 301 (-3.0A)
SAH  E 301 (-3.6A)
A  G  24 ( 2.5A)
SAH  E 301 (-3.5A)
SAH  E 301 (-3.6A)
0.81A 3nmuA-5ginE:
undetectable
3nmuF-5ginE:
36.5
3nmuA-5ginE:
22.51
3nmuF-5ginE:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
6 / 12 GLY E  84
ALA E  85
GLU E 108
ASP E 133
ALA E 134
ASP E 153
SAH  E 301 (-3.8A)
None
SAH  E 301 (-3.0A)
SAH  E 301 (-3.5A)
SAH  E 301 (-3.6A)
SAH  E 301 (-3.7A)
1.48A 3nmuA-5ginE:
undetectable
3nmuF-5ginE:
36.5
3nmuA-5ginE:
22.51
3nmuF-5ginE:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
9 / 12 LYS E  60
GLY E  84
ALA E  86
GLU E 108
SER E 110
ASP E 133
ALA E 134
ASP E 153
GLN E 156
U  I   4 ( 3.9A)
SAH  E 301 (-3.8A)
SAH  E 301 ( 3.7A)
SAH  E 301 (-3.0A)
A  G  24 ( 2.5A)
SAH  E 301 (-3.5A)
SAH  E 301 (-3.6A)
SAH  E 301 (-3.7A)
SAH  E 301 (-3.8A)
0.69A 3nmuA-5ginE:
undetectable
3nmuF-5ginE:
36.5
3nmuA-5ginE:
22.51
3nmuF-5ginE:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
6 / 11 GLY E  84
ALA E  86
GLU E 108
ALA E 134
ASP E 153
GLN E 156
SAH  E 301 (-3.8A)
SAH  E 301 ( 3.7A)
SAH  E 301 (-3.0A)
SAH  E 301 (-3.6A)
SAH  E 301 (-3.7A)
SAH  E 301 (-3.8A)
0.46A 3nmuB-5ginE:
undetectable
3nmuJ-5ginE:
36.5
3nmuB-5ginE:
22.51
3nmuJ-5ginE:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
7 / 12 LYS E  60
GLY E  84
ALA E  86
ASP E 133
ALA E 134
ASP E 153
GLN E 156
U  I   4 ( 3.9A)
SAH  E 301 (-3.8A)
SAH  E 301 ( 3.7A)
SAH  E 301 (-3.5A)
SAH  E 301 (-3.6A)
SAH  E 301 (-3.7A)
SAH  E 301 (-3.8A)
0.80A 3nvkI-5ginE:
36.0
3nvkI-5ginE:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
6 / 12 ALA E  86
GLU E 108
PHE E 109
ASP E 133
ALA E 134
GLN E 156
SAH  E 301 ( 3.7A)
SAH  E 301 (-3.0A)
SAH  E 301 (-3.6A)
SAH  E 301 (-3.5A)
SAH  E 301 (-3.6A)
SAH  E 301 (-3.8A)
0.88A 3nvkF-5ginE:
undetectable
3nvkJ-5ginE:
36.0
3nvkF-5ginE:
22.46
3nvkJ-5ginE:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
7 / 12 GLY E  84
ALA E  86
GLU E 108
ASP E 133
ALA E 134
ASP E 153
GLN E 156
SAH  E 301 (-3.8A)
SAH  E 301 ( 3.7A)
SAH  E 301 (-3.0A)
SAH  E 301 (-3.5A)
SAH  E 301 (-3.6A)
SAH  E 301 (-3.7A)
SAH  E 301 (-3.8A)
0.61A 3nvkF-5ginE:
undetectable
3nvkJ-5ginE:
36.0
3nvkF-5ginE:
22.46
3nvkJ-5ginE:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
7 / 12 LYS E  60
GLY E  84
ALA E  86
GLU E 108
ASP E 133
ALA E 134
GLN E 156
U  I   4 ( 3.9A)
SAH  E 301 (-3.8A)
SAH  E 301 ( 3.7A)
SAH  E 301 (-3.0A)
SAH  E 301 (-3.5A)
SAH  E 301 (-3.6A)
SAH  E 301 (-3.8A)
0.73A 3nvkF-5ginE:
undetectable
3nvkJ-5ginE:
36.0
3nvkF-5ginE:
22.46
3nvkJ-5ginE:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)
5gin C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT
FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus;
Sulfolobus
solfataricus)
4 / 8 TYR E 105
LEU A  97
ALA A 101
TYR A 114
None
0.84A 3rodA-5ginE:
12.7
3rodA-5ginE:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
4 / 5 SER E  87
THR E  89
GLU E 108
ASP E 133
A  I   6 ( 3.2A)
A  I   6 ( 3.5A)
SAH  E 301 (-3.0A)
SAH  E 301 (-3.5A)
0.94A 3tm4A-5ginE:
14.5
3tm4A-5ginE:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)
5gin 50S RIBOSOMAL
PROTEIN L7AE

(Sulfolobus
solfataricus)
4 / 7 ILE C  55
ILE C  35
SER C  85
GLU C  91
None
0.77A 3ua5B-5ginC:
undetectable
3ua5B-5ginC:
13.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
7 / 12 GLY E  84
ALA E  86
PHE E 109
ASP E 133
ALA E 134
ASP E 153
GLN E 156
SAH  E 301 (-3.8A)
SAH  E 301 ( 3.7A)
SAH  E 301 (-3.6A)
SAH  E 301 (-3.5A)
SAH  E 301 (-3.6A)
SAH  E 301 (-3.7A)
SAH  E 301 (-3.8A)
0.53A 4df3A-5ginE:
33.5
4df3A-5ginE:
53.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
8 / 12 GLY E  84
ALA E  86
THR E  89
PHE E 109
VAL E 113
ASP E 133
ALA E 134
ASP E 153
SAH  E 301 (-3.8A)
SAH  E 301 ( 3.7A)
A  I   6 ( 3.5A)
SAH  E 301 (-3.6A)
None
SAH  E 301 (-3.5A)
SAH  E 301 (-3.6A)
SAH  E 301 (-3.7A)
0.40A 4df3A-5ginE:
33.5
4df3A-5ginE:
53.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
6 / 12 LYS E  60
ALA E  86
THR E  89
VAL E 113
ALA E 134
ASP E 153
U  I   4 ( 3.9A)
SAH  E 301 ( 3.7A)
A  I   6 ( 3.5A)
None
SAH  E 301 (-3.6A)
SAH  E 301 (-3.7A)
0.56A 4df3A-5ginE:
33.5
4df3A-5ginE:
53.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
3 / 3 TYR E  82
THR E  90
GLU E 108
SAH  E 301 (-4.9A)
SAH  E 301 (-3.2A)
SAH  E 301 (-3.0A)
0.40A 4df3A-5ginE:
33.5
4df3A-5ginE:
53.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
7 / 12 GLY E  84
ALA E  86
PHE E 109
ASP E 133
ALA E 134
ASP E 153
GLN E 156
SAH  E 301 (-3.8A)
SAH  E 301 ( 3.7A)
SAH  E 301 (-3.6A)
SAH  E 301 (-3.5A)
SAH  E 301 (-3.6A)
SAH  E 301 (-3.7A)
SAH  E 301 (-3.8A)
0.52A 4df3B-5ginE:
33.6
4df3B-5ginE:
53.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
8 / 12 GLY E  84
ALA E  86
THR E  89
PHE E 109
VAL E 113
ASP E 133
ALA E 134
ASP E 153
SAH  E 301 (-3.8A)
SAH  E 301 ( 3.7A)
A  I   6 ( 3.5A)
SAH  E 301 (-3.6A)
None
SAH  E 301 (-3.5A)
SAH  E 301 (-3.6A)
SAH  E 301 (-3.7A)
0.37A 4df3B-5ginE:
33.6
4df3B-5ginE:
53.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
7 / 12 LYS E  60
GLY E  84
ALA E  86
THR E  89
VAL E 113
ALA E 134
ASP E 153
U  I   4 ( 3.9A)
SAH  E 301 (-3.8A)
SAH  E 301 ( 3.7A)
A  I   6 ( 3.5A)
None
SAH  E 301 (-3.6A)
SAH  E 301 (-3.7A)
0.53A 4df3B-5ginE:
33.6
4df3B-5ginE:
53.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
3 / 3 TYR E  82
THR E  90
GLU E 108
SAH  E 301 (-4.9A)
SAH  E 301 (-3.2A)
SAH  E 301 (-3.0A)
0.39A 4df3B-5ginE:
33.6
4df3B-5ginE:
53.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)
5gin 50S RIBOSOMAL
PROTEIN L7AE
C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT

(Sulfolobus
solfataricus)
4 / 6 GLY C 126
GLN A  75
ARG A  80
ILE C 124
None
1.16A 4e1vF-5ginC:
undetectable
4e1vF-5ginC:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)
5gin 50S RIBOSOMAL
PROTEIN L7AE

(Sulfolobus
solfataricus)
3 / 3 PHE C  12
VAL C  10
GLU C  58
None
0.82A 4fvqA-5ginC:
undetectable
4fvqA-5ginC:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)
5gin C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT
FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus;
Sulfolobus
solfataricus)
4 / 8 ALA A 132
SER A 131
LEU E 131
ARG E 115
None
1.18A 4ijiF-5ginA:
undetectable
4ijiF-5ginA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
4 / 5 LYS E 202
LEU E 203
GLU E 199
LEU E 179
None
1.34A 4k4yA-5ginE:
undetectable
4k4yA-5ginE:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
4 / 4 LYS E 202
LEU E 203
GLU E 199
LEU E 179
None
1.36A 4k4yE-5ginE:
undetectable
4k4yE-5ginE:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
4 / 5 LYS E 202
LEU E 203
GLU E 199
LEU E 179
None
1.35A 4k4yI-5ginE:
undetectable
4k4yI-5ginE:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
4 / 4 ILE E  15
ASN E  14
ILE E  98
VAL E  94
None
1.18A 4uy87-5ginE:
undetectable
4uy87-5ginE:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
4 / 7 ASN E 166
PRO E 137
PHE E 169
PHE E 208
None
1.48A 4v32A-5ginE:
undetectable
4v32A-5ginE:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)
5gin C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT

(Sulfolobus
solfataricus)
4 / 6 SER A 283
LEU A 284
ASP A 285
LEU A 278
None
0.88A 4wozA-5ginA:
undetectable
4wozB-5ginA:
undetectable
4wozA-5ginA:
23.02
4wozB-5ginA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5gin 50S RIBOSOMAL
PROTEIN L7AE

(Sulfolobus
solfataricus)
5 / 10 HIS C  68
THR C  42
THR C  43
SER C 101
ALA C 100
None
None
None
None
U  H  11 ( 3.7A)
1.17A 5eeuO-5ginC:
undetectable
5eeuP-5ginC:
undetectable
5eeuO-5ginC:
22.31
5eeuP-5ginC:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5gin 50S RIBOSOMAL
PROTEIN L7AE

(Sulfolobus
solfataricus)
5 / 10 HIS C  68
THR C  42
THR C  43
SER C 101
ALA C 100
None
None
None
None
U  H  11 ( 3.7A)
1.18A 5eevO-5ginC:
undetectable
5eevP-5ginC:
undetectable
5eevO-5ginC:
22.31
5eevP-5ginC:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5gin 50S RIBOSOMAL
PROTEIN L7AE

(Sulfolobus
solfataricus)
5 / 10 HIS C  68
THR C  42
THR C  43
SER C 101
ALA C 100
None
None
None
None
U  H  11 ( 3.7A)
1.18A 5eewO-5ginC:
undetectable
5eewP-5ginC:
undetectable
5eewO-5ginC:
22.31
5eewP-5ginC:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5gin 50S RIBOSOMAL
PROTEIN L7AE

(Sulfolobus
solfataricus)
5 / 10 HIS C  68
THR C  42
THR C  43
SER C 101
ALA C 100
None
None
None
None
U  H  11 ( 3.7A)
1.18A 5eexO-5ginC:
undetectable
5eexP-5ginC:
undetectable
5eexO-5ginC:
22.31
5eexP-5ginC:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5gin 50S RIBOSOMAL
PROTEIN L7AE

(Sulfolobus
solfataricus)
5 / 10 HIS C  68
THR C  42
THR C  43
SER C 101
ALA C 100
None
None
None
None
U  H  11 ( 3.7A)
1.18A 5eeyO-5ginC:
undetectable
5eeyP-5ginC:
undetectable
5eeyO-5ginC:
22.31
5eeyP-5ginC:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5gin 50S RIBOSOMAL
PROTEIN L7AE

(Sulfolobus
solfataricus)
5 / 10 HIS C  68
THR C  42
THR C  43
SER C 101
ALA C 100
None
None
None
None
U  H  11 ( 3.7A)
1.18A 5eezO-5ginC:
undetectable
5eezP-5ginC:
undetectable
5eezO-5ginC:
22.31
5eezP-5ginC:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5gin 50S RIBOSOMAL
PROTEIN L7AE

(Sulfolobus
solfataricus)
5 / 10 HIS C  68
THR C  42
THR C  43
SER C 101
ALA C 100
None
None
None
None
U  H  11 ( 3.7A)
1.18A 5ef0O-5ginC:
undetectable
5ef0P-5ginC:
undetectable
5ef0O-5ginC:
22.31
5ef0P-5ginC:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5gin 50S RIBOSOMAL
PROTEIN L7AE

(Sulfolobus
solfataricus)
5 / 10 HIS C  68
THR C  42
THR C  43
SER C 101
ALA C 100
None
None
None
None
U  H  11 ( 3.7A)
1.18A 5ef1O-5ginC:
undetectable
5ef1P-5ginC:
undetectable
5ef1O-5ginC:
22.31
5ef1P-5ginC:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5gin 50S RIBOSOMAL
PROTEIN L7AE

(Sulfolobus
solfataricus)
5 / 10 HIS C  68
THR C  42
THR C  43
SER C 101
ALA C 100
None
None
None
None
U  H  11 ( 3.7A)
1.18A 5ef2O-5ginC:
undetectable
5ef2P-5ginC:
undetectable
5ef2O-5ginC:
22.31
5ef2P-5ginC:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5gin 50S RIBOSOMAL
PROTEIN L7AE

(Sulfolobus
solfataricus)
5 / 10 HIS C  68
THR C  42
THR C  43
SER C 101
ALA C 100
None
None
None
None
U  H  11 ( 3.7A)
1.18A 5ef3O-5ginC:
undetectable
5ef3P-5ginC:
undetectable
5ef3O-5ginC:
22.31
5ef3P-5ginC:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
4 / 7 GLU E 108
PHE E 109
ASP E 133
ASP E 153
SAH  E 301 (-3.0A)
SAH  E 301 (-3.6A)
SAH  E 301 (-3.5A)
SAH  E 301 (-3.7A)
0.75A 5ergB-5ginE:
13.3
5ergB-5ginE:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
4 / 7 GLY E  84
GLU E 108
ASP E 133
ASP E 153
SAH  E 301 (-3.8A)
SAH  E 301 (-3.0A)
SAH  E 301 (-3.5A)
SAH  E 301 (-3.7A)
0.60A 5ergB-5ginE:
13.3
5ergB-5ginE:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)
5gin C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT

(Sulfolobus
solfataricus)
5 / 10 GLY A 270
GLN A 362
PHE A 358
ASN A 264
LEU A 278
None
1.30A 5fhzC-5ginA:
undetectable
5fhzC-5ginA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
5 / 12 ASP E 133
ALA E 134
ASP E 153
THR E  89
GLU E 108
SAH  E 301 (-3.5A)
SAH  E 301 (-3.6A)
SAH  E 301 (-3.7A)
A  I   6 ( 3.5A)
SAH  E 301 (-3.0A)
1.31A 5hfjE-5ginE:
3.5
5hfjE-5ginE:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)
5gin 50S RIBOSOMAL
PROTEIN L7AE

(Sulfolobus
solfataricus)
4 / 4 GLU C 106
PRO C 107
ILE C 104
LEU C 105
None
1.28A 5m45A-5ginC:
undetectable
5m45A-5ginC:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)
5gin 50S RIBOSOMAL
PROTEIN L7AE

(Sulfolobus
solfataricus)
4 / 4 GLU C 106
PRO C 107
ILE C 104
LEU C 105
None
1.28A 5m45G-5ginC:
undetectable
5m45G-5ginC:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)
5gin 50S RIBOSOMAL
PROTEIN L7AE

(Sulfolobus
solfataricus)
4 / 4 GLU C 106
PRO C 107
ILE C 104
LEU C 105
None
1.31A 5m45J-5ginC:
undetectable
5m45J-5ginC:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
5 / 12 ILE E  91
GLY E  88
VAL E  38
SER E  92
ALA E 104
None
1.06A 5n0oA-5ginE:
undetectable
5n0oA-5ginE:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)
5gin 50S RIBOSOMAL
PROTEIN L7AE

(Sulfolobus
solfataricus)
5 / 12 ALA C  25
VAL C  22
GLU C 106
ALA C  45
ALA C 103
None
1.13A 5n5dA-5ginC:
undetectable
5n5dA-5ginC:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)
5gin 50S RIBOSOMAL
PROTEIN L7AE

(Sulfolobus
solfataricus)
5 / 12 ALA C  25
VAL C  22
ILE C  78
GLU C 106
ALA C 103
None
1.15A 5n5dB-5ginC:
undetectable
5n5dB-5ginC:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
5 / 12 GLY E  84
VAL E 113
ASP E 133
ALA E 134
ALA E 155
SAH  E 301 (-3.8A)
None
SAH  E 301 (-3.5A)
SAH  E 301 (-3.6A)
U  G  25 (-3.8A)
0.77A 6bq4A-5ginE:
12.7
6bq4A-5ginE:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
5 / 12 GLY E  84
VAL E 113
ASP E 133
ALA E 134
ALA E 155
SAH  E 301 (-3.8A)
None
SAH  E 301 (-3.5A)
SAH  E 301 (-3.6A)
U  G  25 (-3.8A)
0.80A 6bq4B-5ginE:
12.6
6bq4B-5ginE:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYN_A_HSMA901_0
(EBONY)
5gin C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT

(Sulfolobus
solfataricus)
4 / 4 GLU A  70
VAL A  65
LEU A   6
THR A  51
None
1.19A 6dynA-5ginA:
undetectable
6dynA-5ginA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)
5gin C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT

(Sulfolobus
solfataricus)
4 / 5 GLU A  70
VAL A  65
LEU A   6
THR A  51
None
1.25A 6dyoA-5ginA:
undetectable
6dyoA-5ginA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)
5gin 50S RIBOSOMAL
PROTEIN L7AE

(Sulfolobus
solfataricus)
3 / 3 THR C  39
ALA C 100
LYS C  86
U  H  11 ( 3.5A)
U  H  11 ( 3.7A)
U  H  11 ( 3.9A)
0.76A 6fgdA-5ginC:
undetectable
6fgdA-5ginC:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus)
5 / 12 THR E  89
GLY E  88
VAL E 114
GLY E  63
ASP E 220
A  I   6 ( 3.5A)
None
None
None
G  I   5 ( 3.8A)
0.99A 6gngA-5ginE:
2.5
6gngA-5ginE:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_N_PCFN606_0
(CYTOCHROME B)
5gin C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT
FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus;
Sulfolobus
solfataricus)
5 / 12 TYR E  82
TYR E 151
THR E  90
VAL E 143
TYR A 114
SAH  E 301 (-4.9A)
None
SAH  E 301 (-3.2A)
None
None
1.41A 6hu9N-5ginE:
undetectable
6hu9N-5ginE:
20.89