SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5giu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 5giu PROLINE DIPEPTIDASE
(Deinococcus
radiodurans) 		4 / 6 ALA A 233
LYS A 236
ASP A 240
ALA A 241
 None
 0.24A 1iwhA-5giuA:
undetectable		 1iwhA-5giuA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5giu PROLINE DIPEPTIDASE
(Deinococcus
radiodurans) 		4 / 8 ALA A  25
GLU A 290
ASP A 221
ILE A 135
 None
None
PO4  A 401 ( 2.9A)
None
 0.81A 1p7lD-5giuA:
undetectable		 1p7lD-5giuA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5giu PROLINE DIPEPTIDASE
(Deinococcus
radiodurans) 		4 / 8 ALA A  25
GLU A 290
ASP A 221
ILE A 135
 None
None
PO4  A 401 ( 2.9A)
None
 0.79A 1p7lC-5giuA:
undetectable		 1p7lC-5giuA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5giu PROLINE DIPEPTIDASE
(Deinococcus
radiodurans) 		4 / 8 ALA A  25
GLU A 290
ASP A 221
ILE A 135
 None
None
PO4  A 401 ( 2.9A)
None
 0.79A 1rg9B-5giuA:
undetectable		 1rg9B-5giuA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5giu PROLINE DIPEPTIDASE
(Deinococcus
radiodurans) 		4 / 8 ALA A  25
GLU A 290
ASP A 221
ILE A 135
 None
None
PO4  A 401 ( 2.9A)
None
 0.79A 1rg9A-5giuA:
undetectable		 1rg9A-5giuA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5giu PROLINE DIPEPTIDASE
(Deinococcus
radiodurans) 		4 / 8 ALA A  25
GLU A 290
ASP A 221
ILE A 135
 None
None
PO4  A 401 ( 2.9A)
None
 0.80A 1rg9D-5giuA:
undetectable		 1rg9D-5giuA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5giu PROLINE DIPEPTIDASE
(Deinococcus
radiodurans) 		4 / 8 ALA A  25
GLU A 290
ASP A 221
ILE A 135
 None
None
PO4  A 401 ( 2.9A)
None
 0.78A 1rg9C-5giuA:
undetectable		 1rg9C-5giuA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5giu PROLINE DIPEPTIDASE
(Deinococcus
radiodurans) 		3 / 3 ASP A  46
ASP A  17
ASP A  82
 None
 0.73A 2igtA-5giuA:
undetectable		 2igtA-5giuA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5giu PROLINE DIPEPTIDASE
(Deinococcus
radiodurans) 		5 / 12 GLY A 316
LEU A 262
ILE A 331
ASP A 329
LEU A 297
 None
 1.01A 2zbpA-5giuA:
undetectable		 2zbpA-5giuA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 5giu PROLINE DIPEPTIDASE
(Deinococcus
radiodurans) 		4 / 5 ASP A 203
ARG A 154
ILE A 201
VAL A 226
 None
 1.20A 3eigA-5giuA:
undetectable		 3eigA-5giuA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5giu PROLINE DIPEPTIDASE
(Deinococcus
radiodurans) 		5 / 12 ALA A  23
SER A  95
GLU A  94
LEU A 120
GLY A 121
 None
 1.10A 3k2hA-5giuA:
undetectable		 3k2hA-5giuA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5giu PROLINE DIPEPTIDASE
(Deinococcus
radiodurans) 		5 / 12 ALA A  23
SER A  95
GLU A  94
LEU A 120
GLY A 121
 None
 1.10A 3k2hB-5giuA:
undetectable		 3k2hB-5giuA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 5giu PROLINE DIPEPTIDASE
(Deinococcus
radiodurans) 		5 / 12 LEU A 283
PRO A 315
GLY A 284
THR A 312
LEU A 265
 None
None
None
PO4  A 401 ( 4.9A)
None
 1.39A 3okxA-5giuA:
undetectable		 3okxA-5giuA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 5giu PROLINE DIPEPTIDASE
(Deinococcus
radiodurans) 		4 / 6 VAL A 340
TYR A 338
GLU A 246
ILE A 313
 None
 1.10A 3q5sA-5giuA:
undetectable		 3q5sA-5giuA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5giu PROLINE DIPEPTIDASE
(Deinococcus
radiodurans) 		5 / 11 ALA A 249
LEU A 265
ARG A 272
GLY A 299
LEU A 297
 None
 1.24A 3uudA-5giuA:
undetectable		 3uudA-5giuA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5giu PROLINE DIPEPTIDASE
(Deinococcus
radiodurans) 		4 / 8 ALA A  25
GLU A 290
ASP A 221
ILE A 135
 None
None
PO4  A 401 ( 2.9A)
None
 0.73A 4ndnB-5giuA:
undetectable		 4ndnB-5giuA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 5giu PROLINE DIPEPTIDASE
(Deinococcus
radiodurans) 		5 / 10 ALA A 249
LEU A 265
ARG A 272
GLY A 299
LEU A 297
 None
 1.25A 5dxbA-5giuA:
undetectable		 5dxbA-5giuA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5giu PROLINE DIPEPTIDASE
(Deinococcus
radiodurans) 		5 / 11 ALA A 249
LEU A 265
ARG A 272
GLY A 299
LEU A 297
 None
 1.19A 5dxgB-5giuA:
undetectable		 5dxgB-5giuA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 5giu PROLINE DIPEPTIDASE
(Deinococcus
radiodurans) 		4 / 7 VAL A 207
SER A 185
GLY A 204
VAL A 228
 None
 0.92A 5fpdA-5giuA:
3.1		 5fpdA-5giuA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5giu PROLINE DIPEPTIDASE
(Deinococcus
radiodurans) 		4 / 5 TYR A 218
GLY A 217
GLY A  90
LEU A  30
 None
 0.83A 5jlcA-5giuA:
undetectable		 5jlcA-5giuA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 5giu PROLINE DIPEPTIDASE
(Deinococcus
radiodurans) 		5 / 10 VAL A 145
ILE A 166
LEU A 181
GLY A 175
ALA A 173
 None
 0.96A 5mxbA-5giuA:
undetectable		 5mxbA-5giuA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5giu PROLINE DIPEPTIDASE
(Deinococcus
radiodurans) 		5 / 10 ARG A 258
LEU A 283
GLY A 299
LEU A 265
ALA A 266
 None
 1.08A 5o96C-5giuA:
undetectable
5o96D-5giuA:
undetectable		 5o96C-5giuA:
22.97
5o96D-5giuA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5giu PROLINE DIPEPTIDASE
(Deinococcus
radiodurans) 		4 / 8 ALA A  25
GLU A 290
ASP A 221
ILE A 135
 None
None
PO4  A 401 ( 2.9A)
None
 0.91A 5t8sA-5giuA:
undetectable		 5t8sA-5giuA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5giu PROLINE DIPEPTIDASE
(Deinococcus
radiodurans) 		5 / 12 ASP A 303
ILE A 311
GLY A 286
LEU A 262
LEU A 283
 None
 1.01A 5twjC-5giuA:
undetectable		 5twjC-5giuA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 5giu PROLINE DIPEPTIDASE
(Deinococcus
radiodurans) 		5 / 12 ASP A 240
ASP A 329
ALA A 248
LEU A 283
LEU A 270
 None
 1.21A 6ew0F-5giuA:
undetectable		 6ew0F-5giuA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		 5giu PROLINE DIPEPTIDASE
(Deinococcus
radiodurans) 		5 / 12 THR A 128
VAL A 333
PRO A   9
GLU A 293
GLY A 286
 None
 1.44A 6gngB-5giuA:
undetectable		 6gngB-5giuA:
20.89